Blood purification adsorbent for uremia and preparation method of adsorbent

A blood purification and adsorbent technology, applied in chemical instruments and methods, blood circulation treatment, suction equipment, etc., can solve the problems of blood compatibility not widely recognized, inability to facilitate blood purification equipment, etc., to improve strength and toughness , the effect of increased strength, increased proportion and uniformity of distribution

Active Publication Date: 2018-04-06
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although carbon nanotubes have good adsorption properties for blood toxins (VB12), their blood compatibility has not been widely recognized, and powdered carbon nanotubes cannot be conveniently used in blood purification devices

Method used

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  • Blood purification adsorbent for uremia and preparation method of adsorbent
  • Blood purification adsorbent for uremia and preparation method of adsorbent
  • Blood purification adsorbent for uremia and preparation method of adsorbent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Suspension polymerization: 80g styrene, 20g divinylbenzene, 3g multi-walled carbon nanotubes, 2g nano-silicon dioxide, 50g toluene, 30g methylcyclohexane, 1.5g benzoyl peroxide, 0.5g Polyethylene glycol (Mn=2000) is stirred evenly to form an oil phase; mix 300g of water and 0.5g of hydroxyethyl cellulose, and stir evenly to obtain a water phase; add the oil phase to the water phase, stir and suspend at 80°C Reacting for 8 hours, removing the porogen in the polymerized resin to obtain polymeric microspheres;

[0039] (2) Chloromethylation reaction: Soak 60g of polymeric microspheres obtained in step (1) in 300g of chloromethyl ether, let stand at 40°C for 8h, add 20g of anhydrous zinc chloride under mechanical stirring, Chloromethylation reaction under conditions for 30 hours to obtain chlorine spheres;

[0040] (3) Post-crosslinking: swell 50 g of chlorine spheres obtained in step (2) in 300 g of nitrobenzene, add 30 g of zinc chloride, and heat and react at 115° C...

Embodiment 2

[0066] (1) Suspension polymerization: 70g styrene, 5g methylstyrene, 25g divinylbenzene, 10g single-walled carbon nanotubes, 5g nano-silicon dioxide, 50g toluene, 30g paraffin, 1.5g benzoyl peroxide, Stir 0.5g of n-butanol evenly to form an oil phase; mix 300g of water and 5g of gelatin, and stir evenly to obtain a water phase; add the oil phase to the water phase, stir and suspend at 60°C for 10 hours, and polymerize the obtained resin The porogen in the process is removed to obtain polymeric microspheres;

[0067] (2) Chloromethylation reaction: Soak 60g of polymeric microspheres obtained in step (1) in 480g of chloromethyl ether, let stand at 90°C for 1h, add 30g of anhydrous zinc chloride under mechanical stirring, and Chloromethylation reaction under conditions for 5 hours to obtain chlorine spheres;

[0068] (3) Post-crosslinking: swell 50 g of chlorine spheres obtained in step (2) in 400 g of ethylene dichloride, add 10 g of ferric chloride, and heat and react at 60° C...

Embodiment 3

[0074](1) Suspension polymerization: 70g styrene, 30g divinylbenzene, 5g multi-walled carbon nanotubes, 5g nano-silicon dioxide, 50g toluene, 30g cyclohexane, 1g azobisisobutyronitrile, 1g isopropanol Stir evenly to form an oil phase; mix 300g water and 0.5g hydroxyethyl cellulose, and stir evenly to obtain a water phase; add the oil phase to the water phase, stir and suspend at 80°C for 8 hours, and polymerize the obtained resin The porogen in the process is removed to obtain polymeric microspheres;

[0075] (2) Chloromethylation reaction: Soak 60g of polymeric microspheres obtained in step (1) in 300g of chloromethyl ether, let stand at 40°C for 20h, add 20g of anhydrous zinc chloride under mechanical stirring, Chloromethylation reaction under conditions for 30 hours to obtain chlorine spheres;

[0076] (3) Post-crosslinking: swell 50 g of chlorine spheres obtained in step (2) in 300 g of nitrobenzene, add 30 g of zinc chloride, and heat and react at 125° C. for 7 hours to ...

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Abstract

The invention relates to a blood purification adsorbent for uremia and a preparation method of the adsorbent. The blood purification adsorbent is carbon nanotube/nano silica/polystyrene resin composite microspheres, carbon nanotubes and nano silica are dispersed in polystyrene resin, and the polystyrene resin adopts a porous crosslinked structure. The preparation method comprises the steps of suspension polymerization, a chloromethylation reaction, post-crosslinking and surface modification. The provided and prepared blood purification adsorbent has high strength, adsorptive property and adsorption efficiency, has better adsorptive performance for special toxins and is particularly applicable to blood perfusion for uremia.

Description

technical field [0001] The invention relates to the field of blood purification, in particular to a carbon nanotube / nano silicon dioxide / polystyrene resin composite adsorbent suitable for uremic hemoperfusion and a preparation method thereof. Background technique [0002] Hemoperfusion technology is widely used in the fields of poisoning first aid, kidney disease, liver disease and critical illness. Endogenous or exogenous poisons or pathogenic substances, so as to achieve the purpose of blood purification. [0003] The key to the development of hemoperfusion technology is to prepare adsorbent materials with good biocompatibility, strong adsorption performance, high adsorption efficiency or high specificity. At present, the commonly used adsorbent materials for hemoperfusion mainly include activated carbon, natural modified polymers, synthetic polymers, and immunosorbents. Among them, highly cross-linked styrene microsphere adsorption resin has been widely used in hemoperf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30A61M1/36
CPCA61M1/3621A61M1/3633A61M2202/0413B01J20/267A61M2202/0021
Inventor 董凡刘云鸿
Owner JAFRON BIOMEDICAL
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