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Preparation method of high-yield allantoin

A high-yield technology for allantoin, applied in the field of high-yield allantoin preparation, can solve the problems of low allantoin yield, not very good catalytic effect, equipment corrosion, etc.

Inactive Publication Date: 2018-04-17
WUHU HUAHAI BIOLOGY ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing catalysts are generally inorganic strong acids. As a catalyst, inorganic strong acids will cause corrosion to equipment and pollute the environment; what is more important is that the catalytic effect of inorganic strong acid catalysts is not very superior, resulting in a generally low yield of allantoin

Method used

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  • Preparation method of high-yield allantoin

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preparation example Construction

[0017] The invention provides a method for preparing allantoin with high yield, comprising:

[0018] 1) Hydrothermal reaction of molecular sieve, tetrabutyl titanate, zirconium source, sodium tungstate, amino acid, ethanol and water to prepare modified molecular sieve;

[0019] 2) Soak the modified molecular sieve in acid solution to obtain active molecular sieve;

[0020] 3) The active molecular sieve, cyclodextrin, nitrate, and water are subjected to a contact reaction and dried to obtain a catalyst for the preparation of allantoin;

[0021] 4) Oxidation reaction of glyoxal and nitric acid to produce glyoxylic acid, and then condensation reaction of glyoxylic acid, urea, and the catalyst to produce allantoin.

[0022] In step 1) of the present invention, the amount of each material can be selected within a wide range, but in order to make the produced allantoin have a more excellent yield, preferably, in step 1), molecular sieve, titanic acid The weight ratio of tetrabutyl...

Embodiment 1

[0036] 1) Molecular sieve, tetrabutyl titanate, zirconium source (zirconium nitrate), sodium tungstate, amino acid, ethanol, and water are subjected to hydrothermal reaction according to the weight ratio of 10:1.5:0.6:0.4:0.10:7:13 (reaction The temperature is 210°C, and the reaction time is 6h) to prepare modified molecular sieves;

[0037] 2) Soak the modified molecular sieve and acid solution (pH 5.8, hydrochloric acid aqueous solution) according to the weight ratio of 10:40 (soaking temperature is 40°C, soaking time is 20h) to prepare active molecular sieve;

[0038] 3) The active molecular sieve, cyclodextrin, nitrate (sodium nitrate), and water are subjected to a contact reaction according to a weight ratio of 10:0.5:1.3:25 (reaction temperature is 85°C, reaction time is 12h), and dried to obtain Catalyst for the preparation of allantoin;

[0039] 4) Carry out oxidation reaction of glyoxal and nitric acid at a molar ratio of 1:1.1 (reaction temperature is 41°C, reaction...

Embodiment 2

[0041] 1) Molecular sieve, tetrabutyl titanate, zirconium source (zirconium hydroxide), sodium tungstate, amino acid, ethanol, and water are subjected to hydrothermal reaction according to the weight ratio of 10:1:0.5:0.2:0.08:5:10 ( The reaction temperature is 200°C, and the reaction time is 4h) to prepare modified molecular sieves;

[0042] 2) Soak the modified molecular sieve and acid solution (pH 5.5, phosphoric acid aqueous solution) in a weight ratio of 10:30 (soaking temperature is 30°C, soaking time is 12h) to prepare active molecular sieve;

[0043] 3) The active molecular sieve, cyclodextrin, nitrate (potassium nitrate), and water are subjected to a contact reaction in a weight ratio of 10:0.4:1:20 (reaction temperature is 80°C, reaction time is 10h), and dried to obtain Catalyst for the preparation of allantoin;

[0044]4) Carry out oxidation reaction of glyoxal and nitric acid at a molar ratio of 1:1.05 (reaction temperature is 40°C, reaction time is 4h) to produc...

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Abstract

The invention discloses a preparation method of high-yield allantoin, comprising: 1) subjecting molecular sieve, tetrabutyl titanate, a zirconium source, sodium tungstate, amino acids, ethanol and water to hydrothermal reaction to obtain modified molecular sieve; 2) soaking the modified molecular sieve in an acid liquid to obtain activated molecular sieve; 3) subjecting the activated molecular sieve, cyclodextrin, nitrates and water to contact reaction, and drying to obtain a catalyst to prepare allantoin; 4) subjecting glyoxal and nitric acid to oxidation reaction to obtain glyoxylic acid, and subjecting the glyoxylic acid, urea and the catalyst to condensation reaction to obtain allantoin. The preparation method imparts high yield to allantoin and has the advantages that environmental friendliness is achieved and the catalyst is easy to reclaim.

Description

technical field [0001] The invention relates to a catalyst, in particular to a method for preparing allantoin with high yield. Background technique [0002] Allantoin, English name Allantion, chemical name 1-ureidodiazolane-2,4-dione, is an important fine chemical product with a wide range of uses. Allantoin has physiological functions such as promoting the growth of skin epithelial cells, healing sores, relieving pain, and softening keratin. It is also non-toxic, non-irritating, non-allergic, has light-proof, bactericidal, anti-corrosion, and anti-oxidation effects, and can keep the skin hydrated. , Moisturizing and soft, so it is widely used in the production of medicine and cosmetics. In addition, allantoin also has the function of stimulating biological growth, and can be used as a plant growth regulator in agricultural production, with effects such as fruit strengthening, ripening, and yield increase. [0003] Natural allantoin exists in the excrement of some animals ...

Claims

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Application Information

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IPC IPC(8): C07D233/88B01J31/38
CPCB01J31/065B01J31/38C07D233/88
Inventor 茆振斌
Owner WUHU HUAHAI BIOLOGY ENG
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