Modification method of ts-1 and its application in solvent-free catalyzed preparation of pyruvate from lactate

A technology for catalyzing lactate and TS-1, which is applied in the preparation of carboxylate, catalyst activation/preparation, preparation of organic compounds, etc. Effect

Active Publication Date: 2020-09-04
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when there is no solvent, under the same conditions, the yield of pyruvate is only 17%
The use of solvent will directly lead to the increase of production cost

Method used

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  • Modification method of ts-1 and its application in solvent-free catalyzed preparation of pyruvate from lactate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]In this example, the modification of commercialized TS-1 and the catalytic oxidation of ethyl lactate to prepare ethyl pyruvate:

[0039] The modification process of TS-1 went through the first water vapor treatment, the second crystallization, the second water vapor treatment and the washing liquid treatment in sequence.

[0040] The first steam treatment: Take 1.0 g of commercial TS-1 and place it in a fixed-bed reactor, raise the temperature to 500°C, and pass 100% steam for 2 hours. Then the feed of water vapor was stopped, and the temperature of the reactor was lowered to room temperature under nitrogen atmosphere.

[0041] Secondary crystallization: take out TS-1, and grind it with 0.5 g of tetrapropylammonium bromide in a mortar for 3 hours. Next, the ground solid was transferred to a polytetrafluoroethylene-lined crystallization kettle, and 10 mL of propanol solvent was added and stirred for 30 minutes. After sealing the crystallization kettle, let it stand at ...

Embodiment 2

[0049] In this example, the modification of commercialized TS-1 and the catalytic oxidation of ethyl lactate to prepare ethyl pyruvate:

[0050] In the modification method, except that the 0.1M dilute sulfuric acid was replaced by 0.1M phosphoric acid during the washing solution treatment, other modification conditions were the same as in Example 1.

[0051] The modified TS-1 was used to catalyze the oxidation of ethyl lactate to prepare ethyl pyruvate under solvent-free conditions, and the reaction conditions were exactly the same as in Example 1. The reaction results are shown in Table 1.

Embodiment 3

[0053] In this example, the modification of commercialized TS-1 and the catalytic oxidation of ethyl lactate to prepare ethyl pyruvate:

[0054] In the modification method, except that the hydrogen peroxide with a mass fraction of 30% was replaced by 0.1M sodium hypochlorite in the washing liquid treatment process, other modification conditions were the same as in Example 1.

[0055] The modified TS-1 was used to catalyze the oxidation of ethyl lactate to prepare ethyl pyruvate under solvent-free conditions, and the reaction conditions were exactly the same as in Example 1. The reaction results are shown in Table 1.

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Abstract

The invention provides a modification method of TS-1 and an application of TS-1 to preparation of pyruvate from lactate via solvent-free catalysis. The modification method mainly comprises primary water vapor treatment, secondary crystallization, secondary water vapor treatment and washing lotion treatment to the commercial TS-1 in sequence. The primary water vapor treatment is carried out on a fixed bed reactor; the secondary crystallization comprises performing solid grinding on tetrapropylammonium bromide which is a template and TS-1 and performing solvent heat treatment in a crystallization kettle; the secondary water vapor treatment is similar to the primary water vapor treatment; and the washing lotion treatment comprises washing with an acidic washing lotion, an alkaline washing lotion and an oxidative washing lotion in sequence. The modified TS-1 can catalyze hydrogen-peroxide-oxidized lactate with high efficiency in a solvent-free system to prepare pyruvate. In a mild condition, the yield of pyruvate can reach no less than 95%. The catalyst shows super high stability and can be cycled for 20 times, and the yield of pyruvate can be maintained no less than 95%.

Description

technical field [0001] The invention relates to a modification method of TS-1 and its application in the preparation of pyruvate by catalyzing lactate without solvent. Background technique [0002] Pyruvate and its ester derivatives are important chemical intermediates, widely used in energy, food, cosmetics, spices and other industries; at the same time, pyruvic acid (ester) can also be used to produce a variety of biologically active substances, such as antiviral drugs, Animal cell culture medium, etc. At present, the commercial production of pyruvate (ester) is mainly realized by dehydration and decarboxylation of tartrate. However, this process requires the consumption of excess KHSO 4 As a decarboxylation agent, the production cost of this process is high, the atom economy is low, and the environmental pollution is serious. Pyruvate (ester) can also be obtained by biological fermentation of sugars. However, this process requires high precision control of reaction con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J29/89B01J37/10B01J37/06C07C67/313C07C69/716
CPCB01J29/89B01J37/06B01J37/10B01J2229/36B01J2229/37B01J2229/38C07C67/313C07C69/716
Inventor 芦天亮周利鹏杨晓梅苏运来
Owner ZHENGZHOU UNIV
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