Preparation method of cordyceps Chongcao Qishen capsules

A technology of Cordyceps and capsules, which is applied in the direction of capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of poor stability of injections and easy precipitation and precipitation, and achieve excellent results, improve extraction efficiency, and high active ingredients. Effect

Active Publication Date: 2018-06-08
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently commercially available Astragalus injection is generally prepared by water extraction and alcohol precipitation. The active ingredient in the injection is Astragalus saponin, which does not contain astragalus polysaccharide or has very little content. Astragalus polysaccharide is also an active i

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation method of Cordyceps Qishen Capsules comprises the steps of:

[0020] 1) Take 140g of Cordyceps sinensis and grind it into fine powder;

[0021] 2) Take 1400g of astragalus, crush it, pass through a 200-mesh sieve, put it in a container, add twice the weight of 85% (v / v) ethanol, stir and extract at 300rpm, control the microwave power to 500W during the extraction process, and the extraction time to 60 -90min; then placed at 4°C for 12h, filtered, and the filter residue was set aside; the filtrate was evaporated under reduced pressure to recover ethanol, and the filtrate was concentrated to extract A with a density of 1.2g / ml; the astragalus in the extract was tested by high performance liquid chromatography Glycoside content is 1.29mg / ml;

[0022] Add twice the weight of water to the filter residue, stir well, then add 0.5wt% neutral protease (200,000 U / g), enzymatically hydrolyze at 37°C for 120min, then boil for 5min, then add anhydrous Ethanol, stir...

Embodiment 2

[0037] Animal Toxicity Test

[0038] 40 healthy Kunming strain mice, half male and half female, body weight 18.9±1.7g, 40 mice were randomly divided into two groups, each group was half male and half male, and 20 of them were used as the control group and fed with normal water; 20 mice were given the preparation prepared by the process of Example 1, the dose was 100mg / kg, three times a day, and the toxicity test was carried out with mice to show that: compared with the control group, no significant difference was seen in the mice after administration, and the experiment was continuously observed for two weeks , the general condition of the mice, food intake, drinking water, and weight gain were all normal. On the day of administration and within two weeks after administration, no animal died, suggesting that the drug has low toxicity and is safe for clinical use.

Embodiment 3

[0040] Drug efficacy comparison test

[0041] Animals: 60 SD male rats, weighing 223±17g, healthy and clean, raised in the experimental animal center of our company.

[0042] Grouping treatment: 60 SD male rats, 15 were randomly selected as the blank control group according to no significant difference in body weight, and the remaining 45 were prepared for doxorubicin nephropathy model. The root of model rats was randomly divided into model control group (gastric administration of normal saline, dose 100 mg / kg), embodiment 1 group (gastric administration of the preparation of Example 1, dose 100 mg / kg), control group 1 (gastric administration of control The preparation of Example 1, dose 100mg / kg), 15 rats in each group. Gastrointestinal administration once a day for one month in a row. The rats in each group were collected 24h urine volume at the beginning and end of the experiment to measure the 24h urine protein (sulfallic acid method).

[0043] Observation indicators: i...

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PUM

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Abstract

The invention belongs to the technical field of Chinese herbal medicine extraction and discloses a preparation method of Chongcao Qishen capsules. The preparation method comprises steps as follows: step 1) preparation of fine powder of cordyceps sinensis, step 2) preparation of a radix astragali extract, step 3) preparation of a radix salviae miltiorrhizae extract, step 4) preparation of a flos carthami extract, step 5) preparation of a spina date seed extract, and step 6) uniform mixing, crushing and drying. The preparation process is simple and feasible, different traditional Chinese medicine ingredients are treated with different technologies, effective ingredients in raw materials are increased, the efficacy is increased, and waste of the raw materials is reduced.

Description

technical field [0001] The invention belongs to the technical field of extracting Chinese herbal medicines, and in particular relates to a preparation method of Cordyceps Qishen Capsules. Background technique [0002] Kidney disease has not received enough attention from everyone, but when it evolves into renal failure-uremia, its harm is no less than cancer, and the incidence of kidney disease in my country is also due to irregular treatment, drug abuse and unhealthy lifestyle. rising year after year. Chronic nephritis, also known as chronic glomerulonephritis, is a group of glomerular diseases with various etiologies, different pathological forms and similar clinical manifestations. , accompanied by varying degrees of renal dysfunction, often recurrent, protracted and difficult to heal, anemia, retinopathy and uremia may occur in the later stage, and even life-threatening. The main manifestations are: (1) edema; (2) high blood pressure; (3) pain in the renal area and rena...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61K9/48A61P13/12
CPCA61K9/4841A61K36/068A61K36/286A61K36/481A61K36/537A61K36/725A61K2236/19A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 林凡奎吴士平王萍
Owner XIANGYU PHARMA
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