A kind of cyclopropylamine continuous production system and production method

Abstract

The invention belongs to the field of chemical production, and in particular relates to a continuous production system and production method of cyclopropylamine. The continuous production system of cyclopropylamine comprises the following production devices connected in sequence: a primary reaction still, a secondary reaction still, an ammoniation reactor, a deammonization tank, a flash tank, a methanol removal tower, a phase separator and degradation reactor. The invention relates to a method for producing cyclopropylamine by using the cyclopropylamine continuous production system, which solves the problem of intermittent production of cyclopropylamine in the prior art; improves the fluidity and filterability of materials in the processes of cyclization, ammoniation and ammoniation distillation ; Improve the cyclopropyl formamide degradation process, while ensuring high conversion rate and high cyclopropylamine yield to achieve, to achieve continuous production of cyclopropylamine.

Description

technical field [0001] The invention belongs to the field of chemical production, and in particular relates to a continuous production system and production method of cyclopropylamine. Background technique [0002] Cyclopropylamine (CPA) is an aliphatic amine with a three-membered ring. It is an important pharmaceutical intermediate and is widely used in the fields of medicine and pesticides. It can be used to synthesize antibacterial drugs such as ciprofloxacin, enrofloxacin and sparfloxacin. , It can also be used to prepare chemical herbicides such as cyproterachlor and ciprozine. [0003] One of the methods for producing cyclopropylamine in the factory at present is: using methyl chlorobutyrate as raw material, generating methyl cyclopropanate through cyclization reaction with sodium methoxide, methyl cyclopropanate is ammoniated at medium temperature and pressure to generate cyclopropylamine Propyl formamide (CPCA) and cyclopropyl formamide undergo Hoffman degradation w...

AI Technical Summary

Problems solved by technology

[0006] In the first step of the cyclization reaction, a large amount of NaCl is generated, and the presence of salt in the organic phase (such as xylene) will increase the viscosity of the reaction solution, reduce its fluidity, and bring inconvenience and variables to continuous production.

The cyclopropyl formamide generated by the second step of the ammoniation reaction is less soluble in solvents (such as xylene), so the cyclopropyl formamide also precipitates when the temperature is lower, making the fluidity of the reaction solution worse.

The content of alkali in the solution, the reaction temperature and the amount of available chlorine all have varying degrees of influence on the three stages of the Hoffmann degradation process, which makes the reaction yield very variable and brings a lot to the realization of continuous operation. The problem

[0007] So far, due to the above-mentioned various technical problems, the intermittent operation process adopted in the industrial production of cyclopropylamine has low production efficiency, low and unstable product yield, and there is also a lot of room for improvement.

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