Antimicrobial, insecticidal and acaricidal system

A system and carrier particle technology, used in the fields of antibacterial, acaricidal compounds, and insecticides, it can solve problems such as poor taste, reduced pest efficacy, and not always achieved, achieve enhanced chemical and thermal stability, reduced minimum concentration, Long-lasting effect

Inactive Publication Date: 2018-06-08
UNIV POLITECNICA DE VALENCIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, although the encapsulation of active compounds within mesoporous particles offers advantages in terms of controlled and sustained release of compounds, these techniques are not entirely satisfactory.
For example, one disadvantage of this technique is that, once the active compound is released from the mesoporous particles, it is free in the environment and thus has the same disadvantages (e.g. in terms of solubility, volatility (due to Reduced effectiveness against pests due to poor persistence), bad taste, etc.)
Furthermore, when the released compounds are dispersed in the environment, it is not possible to obtain substantial concentrations of said compounds in specific regions of interest
In addition, depending on the ratio of polarities and the ratio of pore size to compound particle size, it is not always possible to introduce the compound into the pores.
On the other hand, the use of porous substances with large diameter pores complicates their closure and thus the effective encapsulation of added compounds

Method used

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  • Antimicrobial, insecticidal and acaricidal system
  • Antimicrobial, insecticidal and acaricidal system
  • Antimicrobial, insecticidal and acaricidal system

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0055] The first study was the functionalization of vanillin on MCM-41 mesoporous particles and its antibacterial activity.

[0056] To this end, an in vitro assay was performed to determine the effect of L. innocaria ( Listeria innocua ) of bacterial viability. In the absence of pellets or active compound (positive control), microbial survival was determined as 100% of the population to calculate survival in treated samples.

[0057] For this purpose, different suspensions of granules or free vanillin in broth medium (tryptone soy broth) were prepared and added with microbial inoculum to obtain about 10 6 Initial population of CFU / ml. The suspension was incubated for 2 hours at 37°C with orbital agitation (150 rpm). Then, serial dilutions were inoculated in selective medium for 48 hours, followed by counting colony forming units (CFU) and calculating percent inhibition.

[0058] attached figure 1 Shown is the effect of different concentrations of free vanillin (left pa...

example 2

[0063] A study similar to that described in Example 1 was performed to determine the antibacterial activity of carvacrol functionalized on MCM-41 microparticles compared to free carvacrol.

[0064] attached figure 2 Shown are the anti-L. innocuae ( Listeria innocua ) percent inhibition of cultures.

[0065] Depend on figure 2 It can be seen that after carvacrol is anchored on the silica microparticles in the same manner as the previous example, its antibacterial activity is maintained.

[0066] Results similar to those described in Examples 1 and 2 above were also obtained using different sized carrier particles (data not shown).

example 3

[0068] The possible mechanism of action of the antibacterial compounds functionalized on the carrier particles was investigated by transmission electron microscopy (TEM). image 3 shows Listeria innocua ( L. innocua ) Morphological changes after treatment with functionalized MCM-41 particles.

[0069] It can be observed that the treated cells exhibit severe morphological damage, rupture of membranes and cell walls, and loss of intracellular components. These results confirm that active compounds functionalized on carrier particles are identical to their free forms and primarily target the outer cell envelope.

[0070] Example 4 (comparative example):

[0071] The anchoring of octanoic acid on mesoporous MCM-41 particles was studied. Caprylic acid is a medium-chain fatty acid that has been shown to have antimicrobial activity against a variety of microorganisms, but its use is limited due to its strong rancid odor. Therefore, anchoring of caprylic acid on MCM-41 micropar...

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Abstract

The present invention relates to an antimicrobial, insecticidal and acaricidal system comprising functionalised support particles with at least one antimicrobial compound of natural origin. The particles are preferably selected from the group formed by silica-based inorganic materials, for example mesoporous particles of silicon oxide or particles of amorphous silicon oxide, and also cellulose particles, for example microcrystalline cellulose, while the antimicrobial compound is preferably selected from the group formed by carvacrol, cinnamaldehyde, perillaldehyde, eugenol, thymol, vanillin, gallic acid and ferulic acid.

Description

technical field [0001] The invention relates to the field of antibacterial, insecticidal and acaricidal compounds, in particular to an antibacterial, insecticidal and acaricidal system for applying the compound. Background of the invention [0002] Plant metabolites such as active compounds of essential oils and organic acids of plant extracts have shown proven acaricidal, antibacterial, and insecticidal activities against different pests ("Mimia mimosa antibacterial gallic acid", "Food Chemistry" 2007 No. 100 Vol. 3, pp. 1044-1048; "Biological Effects of Essential Oils—A Review", "Food and Chemical Toxicology", Vol. 46, No. 2, pp. 446-475, 2008; "Essential Oils in Food Preservation: Modes of Action , synergy and interaction with food matrix components", "Frontiers in Microbiology" 2012 No. 3) ("Antimicrobial gallic acid from Caesalpinia mimosoides Lamk." Food Chemistry, 100(3), 1044-1048, 2007; "Biological effects of essential oils–a review." Food and Chemical Toxicology, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K31/085A61K47/52A61P31/04C01B33/18
CPCA61K31/05A61K31/085C01B33/18A01N25/08A01N25/10A01N25/26A01N25/34A61P31/04A01N31/08A01N31/14A01N35/04A01N37/02A01N37/38A01N37/40A61K47/50A61K31/185B01D39/18C02F1/001C02F2303/04D06M13/12D06M13/144
Inventor 何塞·曼纽埃尔·巴拉特·巴维拉玛丽亚·多勒瑞斯·马克思·马丁内兹拉蒙·马丁内兹·曼内兹埃德加·佩雷兹·埃斯特维玛丽亚·路易兹·瑞科费利克斯·桑切侬·加拉扎
Owner UNIV POLITECNICA DE VALENCIA
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