Tissue defect repairing film loader and preparation method thereof

A carrier and tissue technology, used in tissue regeneration, medical science, nose implants, etc., can solve the problems of repairing membrane without a supporting carrier or the carrier is not easy to plasticize new wounds and complications, etc. The effect of uniform thickness and cost reduction

Active Publication Date: 2018-06-19
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a tissue defect repair membrane carrier and its preparation method to solve the problem that the rep...

Method used

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  • Tissue defect repairing film loader and preparation method thereof
  • Tissue defect repairing film loader and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of the tissue defect repair membrane carrier of this embodiment includes:

[0035] (1) Put dimethyl / methyl vinyl siloxane copolymer and fiber-reinforced silica in a mass ratio of 0.8:1.2 into a rubber mixer and knead for 1 min, then pour it into a mold and heat it at 160°C Forming under vacuum for 3 minutes, and then performing vulcanization treatment under an inert atmosphere at 200°C to obtain the carrier body;

[0036] (2) Coating the polymer polysaccharide solution on the surface of the carrier body by casting method, standing for 15 minutes, and then drying in an oven at 40°C for 8 hours. Preferably, the polymer polysaccharide is chitosan.

[0037] (3) Soak the dried carrier body in a 0.08 mol / L sodium hydroxide solution for 3 hours, wash with distilled water until the solution becomes neutral, and then dry to prepare the carrier.

Embodiment 2

[0039] The preparation method of the tissue defect repair membrane carrier of this embodiment includes:

[0040] (1) Put the dimethyl / methyl vinyl siloxane copolymer and fiber-reinforced silica into the rubber mixer according to the mass ratio of 1.2:0.8 and knead for 20 minutes, then pour it into the mold and put it in the 100℃ Forming under vacuum for 2 minutes, and then performing vulcanization treatment under an inert atmosphere at 300°C to obtain the carrier body;

[0041] (2) Coating the polymer polysaccharide solution on the surface of the carrier body by casting method, standing for 20 minutes, and then drying in an oven at 50°C for 6 hours. Preferably, the polymer polysaccharide is one or more combinations of sodium hyaluronate and its derivatives, and cellulose polysaccharide derivatives.

[0042] (3) Soak the dried carrier body in a 0.12 mol / L sodium hydroxide solution for 2 hours, wash with distilled water until the solution becomes neutral, and then dry to prepar...

Embodiment 3

[0044] The preparation method of the tissue defect repair membrane carrier of this embodiment includes:

[0045] (1) Put dimethyl / methyl vinyl siloxane copolymer and fiber-reinforced silica into the rubber mixer according to the mass ratio of 1:1 and knead for 15 minutes, then pour it into the mold and place it in the empty state at 120 Molding for 2.5 minutes, and then vulcanized under an inert atmosphere at 250°C to obtain the main body of the carrier;

[0046](2) Coating the polymer polysaccharide solution on the surface of the carrier body by casting method, standing for 18 minutes, and then drying in an oven at 45°C for 7 hours. Preferably, the polymer polysaccharide is cellulose polysaccharide.

[0047] (3) Soak the dried carrier body in a 0.1 mol / L sodium hydroxide solution for 2.5 hours, wash with distilled water until the solution becomes neutral, and then dry to prepare the carrier.

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Abstract

The invention discloses a tissue defect repairing film loader and a preparation method thereof, belonging to the technical field of medical equipment. The preparation method comprises the following steps: mixing a dimethyl/methyl vinyl siloxane copolymer and fiber enhanced silicon dioxide, in a mass ratio of (0.8-1.2):(0.8-1.2), in a mixing machine; pouring the mixture into a mould, and moulding in a vacuum state at 100-160 DEG C; performing sulfurizing treatment in an inert atmosphere at 200-300 DEG C to obtain a loader body; coating the surface of the loader body with a high molecular polysaccharide solution by a tape casting process; and drying to obtain the tissue defect repairing film loader. The preparation method disclosed by the invention is simple; the tissue defect repairing filmloader can be shaped freely according to clinical needs so as to help a doctor judge the wound size; moreover, the tissue defect repairing film loader perfectly fits a biofilm material while having afixing and supporting ability, thereby promoting regeneration and repair of the wound tissue; and meanwhile, the loader can be applied to human body safely, and has good tissue compatibility.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a tissue defect repair membrane carrier and a preparation method thereof. Background technique [0002] In the face of mucosal repair accompanied by bone defects, such as perforation of the nasal septum, bony defect of the nasal skull base, and perforation of the hard palate, the surgical operation is difficult and the treatment effect is poor due to the physiological narrowness of the lesion site; moreover, autologous tissue materials Repair inevitably brings new trauma and complications, and the existing biofilm repair often autolyzes due to the lack of hard bone support, resulting in the inability to complete epithelialized repair of the mucosa. Contents of the invention [0003] The purpose of the present invention is to provide a tissue defect repair membrane carrier and its preparation method to solve the problem that the repair membrane has no supporting carrier ...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/04A61L31/14A61F2/18
CPCA61L31/042A61L31/06A61L31/14A61F2/186A61F2240/002A61L2300/412A61L2430/02C08L83/04C08L5/08C08L5/00Y02W90/10
Inventor 刘锋郭刚钟兵
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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