Superparamagnetism-plasma composite microsphere and preparation method thereof

A plasma and composite microsphere technology, applied in chemical instruments and methods, alkali metal compounds, other chemical processes, etc., can solve the problems of complex preparation process, nano-templates without metal affinity, and low particle coating density. , to achieve and tune the plasmonic optical effect, the excellent plasmonic optical effect, and the simple and easy preparation method.

Active Publication Date: 2018-07-03
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Generally speaking, the main disadvantages of the current technology for preparing superparamagnetic-plasmonic microspheres are: the nano-templates used do not have metal affinity, resulting in low particle coating density and poor magnetic response; group modification, and the additional preparat

Method used

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  • Superparamagnetism-plasma composite microsphere and preparation method thereof
  • Superparamagnetism-plasma composite microsphere and preparation method thereof
  • Superparamagnetism-plasma composite microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Measure 40mL of ethanol, 90mL of ultrapure water and 2.2mL of ammonia water, and pour them into a 250mL reaction bottle. Weigh 0.5 g of dopamine hydrochloride and dissolve it in 10 mL of water, quickly add it into the above mixed solution under vigorous stirring, and magnetically stir at room temperature for 30 h. The solution was centrifuged to collect the precipitate and washed several times with water to obtain 100 nm polydopamine microspheres.

[0057] (2) Polydopamine microspheres (about 50 mg in dry weight) were dissolved in 0.5 mL of ethanol and added to a 50 mL two-necked reaction flask. Then 120 mg of iron acetylacetonate and 10 mL of triethylene glycol were added. The temperature of the solution was raised to 70 °C under vacuum and maintained for more than 15 min to remove ethanol. After filling the bottle with nitrogen or argon, the temperature was raised to 210° C. and magnetically stirred for 2 h; under the inert gas atmosphere, the temperature was ra...

Embodiment 2

[0062] (1) Measure 40mL of ethanol, 90mL of ultrapure water and 0.68mL of ammonia water, and pour them into a 250mL reaction bottle. Weigh 0.5 g of dopamine hydrochloride and dissolve it in 10 mL of water, quickly add it into the above mixed solution under vigorous stirring, and magnetically stir at room temperature for 30 h. The solution was centrifuged to collect the precipitate and washed several times with water to obtain 370nm polydopamine microspheres;

[0063] (2) Polydopamine microspheres (about 50 mg in dry weight) were dissolved in 0.5 mL of ethanol and added to a 50 mL two-necked reaction flask. Then 120 mg of iron acetylacetonate and 10 mL of triethylene glycol were added. The temperature of the solution was raised to 70 °C under vacuum and maintained for more than 15 min to remove ethanol. After filling the bottle with nitrogen or argon, the temperature was raised to 210° C. and magnetically stirred for 2 h; under the inert gas atmosphere, the temperature was ra...

Embodiment 3

[0068] (1) Measure 80mL of ethanol, 180mL of ultrapure water and 1.36mL of ammonia water, and pour them into a 500mL reaction bottle. Weigh 1.0 g of dopamine hydrochloride and dissolve it in 20 mL of water, quickly add it into the above mixed solution under vigorous stirring, and magnetically stir at room temperature for 30 h. The solution was centrifuged to collect the precipitate and washed several times with water to obtain 370nm polydopamine microspheres;

[0069] (2) Polydopamine microspheres (about 100 mg in dry weight) were dissolved in 1.0 mL of ethanol and added to a 100 mL two-necked reaction flask. Then 240 mg of iron acetylacetonate and 20 mL of triethylene glycol were added. The temperature of the solution was raised to 70 °C under vacuum and maintained for more than 15 min to remove ethanol. After filling the bottle with nitrogen or argon, the temperature was raised to 210° C. and magnetically stirred for 2 h; under the inert gas atmosphere, the temperature was...

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Abstract

The invention relates to a superparamagnetism-plasma composite microsphere and a preparation method thereof and particularly discloses the preparation method of the superparamagnetism-plasma compositemicrosphere. The preparation method comprises the following steps: (1) synthesizing a polydopamine microsphere, (2) synthesizing a superparamagnetism microsphere, (3) carrying out surface activationon the superparamagnetism microsphere, (4) growing gold seeds on the surface of the superparamagnetism microsphere, and (5) growing a gold nano-shell on the surface of the superparamagnetism microsphere. The superparamagnetism-plasma composite microsphere provided by the invention contains a core of the polydopamine microsphere, wherein the core is loaded with iron oxide particles growing in situand the iron oxide particles are externally coated with dopamine ligands and a gold nanoparticle shell grown in an in situ nucleation manner. The superparamagnetism-plasma composite microsphere is capable of realizing rapid superparamagnetism response and has excellent and tunable plasma optical effects; and the preparation method is simple, convenient and feasible and convenient to repeat and popularize.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a superparamagnetic-plasma composite microsphere. Background technique [0002] Superparamagnetic iron oxide nanoparticles have excellent biocompatibility and can achieve targeted enrichment of target molecules under the action of an external magnetic field. It has great application potential in pollutant enrichment and monitoring. Among many magnetic nanoparticles, Fe with particle size less than 20nm 3 o 4 Nanoparticles are widely used in biomedical fields such as separation and purification of biomolecules, cell labeling, clinical magnetic resonance imaging, and targeted drug delivery due to their superparamagnetic properties, relatively simple preparation, and biodegradable utilization. On the one hand, under the action of an external magnetic field, the small-sized Fe 3 o 4 Exhibits a high saturation magnetization, Fe 3 o 4 No residual magnetism. This property ens...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28B01J20/30
CPCB01J20/02B01J20/06B01J20/262B01J20/28009B01J20/28019B01J2220/46
Inventor 粟武黄亮敖丽娇
Owner SHENZHEN INST OF ADVANCED TECH
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