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A kind of walnut peptide enteric-coated pellet and preparation method thereof

A technology of enteric-coated pellets and walnut peptides, which is applied in the functions of food ingredients, food shaping, food science, etc., and can solve the problems of reduced bioavailability

Active Publication Date: 2021-06-15
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of pellets is usually difficult to achieve good encapsulation efficiency and drug loading, and the impact of packaging materials on the release rate of active substances may directly lead to the reduction of bioavailability

Method used

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  • A kind of walnut peptide enteric-coated pellet and preparation method thereof
  • A kind of walnut peptide enteric-coated pellet and preparation method thereof
  • A kind of walnut peptide enteric-coated pellet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] (1) ball core

[0105] Walnut peptide 600g, starch 200g, cyclodextrin 95g, polyoxyethylene pyrrolidone 5g, sodium cholate 50g, chitosan 30g, sodium alginate 20g, mix evenly, soft material made of 85% ethanol, pass through a 30-mesh sieve to get wet granules . Put the wet granules in a 60-80r / min coating pan, seal and roll for 10-30min, open the lid, heat the pot wall to 40-60°C, dry and roll for 1-2h, dry the ball core in an oven, and use a 20-24 mesh sieve Net sieve to get pellet core (particle size 700~830μm).

[0106] (2) Isolation layer coating

[0107] Evenly disperse 76g of HPMC-E5 and 4g of talc powder in water to obtain a coating solution for the isolation layer; take 1000g of the pellet core in (1), and use a fluidized bed bottom spray coating at a coating temperature of 40°C, and continue to dry for 15 minutes after the coating is completed , to obtain the isolation layer coated ball core.

[0108] (3) Enteric layer coating

[0109] Will Disperse 45g of...

Embodiment 2

[0111] (1) ball core

[0112] Walnut peptide 200g, starch 150g, microcrystalline cellulose 550g, hydroxymethylcellulose sodium 10g, polyethylene glycol 400030g, polyvinylpyrrolidone 10g, sodium deoxycholate 10g, carbomer 5g, konjac gum 5g, mix well , 40% ethanol soft material is passed through a 60-mesh sieve to obtain wet particles. Put the wet granules in a 60-80r / min coating pot, seal and roll for 10-30 minutes, open the lid, heat the pot wall to 40-60°C, dry and roll for 1-2 hours, and dry in a fluidized bed, 40-42 mesh Sieve with a sieve to obtain the pellet core (particle size: 355-380 μm).

[0113] (2) Isolation layer coating

[0114] Evenly disperse 194g of HPC and 6g of talc powder in water to obtain a coating solution for the isolation layer. Take 1000g of medium pellet core, spray coating at the bottom of the fluidized bed, coating temperature is 40°C, and continue drying for 15min after coating is completed, to obtain the isolation layer coated pellet core.

[...

Embodiment 3

[0118] (1) ball core

[0119] Put 530g of sucrose ball cores in a centrifugal granulator, use 500g of 10% sodium hydroxymethylcellulose aqueous solution as a binder, put 400g of walnut peptides, 20g of vitamin E-TPGS, and 10g of xanthan gum into the hopper, and start the spraying process. Slurry, after spraying the adhesive for 4 minutes, after the walnut peptide layering is completed, reduce the spraying speed, continue to polish for 2 minutes, discharge the material, dry it at room temperature until it is almost dry, dry it in a fluidized bed at 40°C for 2 hours, and sieve it with a 16-18 mesh screen A pellet core (particle size 880-1000 μm) is obtained.

[0120] (2) Isolation layer coating

[0121] Will 55g was uniformly dispersed in water to obtain a coating solution. Take 1000 g of the pellet cores in (1), and spray coat them at the bottom of the fluidized bed at a coating temperature of 40°C. After the coating is completed, continue to dry for 15 minutes to obtain th...

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Abstract

The invention relates to the technical field of health food, in particular to a walnut peptide enteric-coated pellet and a preparation method thereof. The walnut peptide enteric-coated pellets prepared by the present invention have a particle size of 200-1000 μm, a release rate of less than 10% in simulated gastric juice for 120 min, and a release rate of more than 70% in simulated intestinal juice for 45 min; Efficiency is significantly improved, with higher oral bioavailability. The experimental results showed that the absorption of walnut peptide raw materials and enteric-coated pellets was evaluated with rat in vivo intestinal valgus model, and it was found that the cumulative absorption of walnut peptide, transport rate and apparent permeability coefficient All were significantly higher than the walnut peptide raw material group, which fully proves that the enteric-coated pellets of the present invention can increase the intestinal absorption of walnut peptide and improve the oral bioavailability of walnut peptide.

Description

technical field [0001] The invention relates to the technical field of health food, in particular to a walnut peptide enteric-coated pellet and a preparation method thereof. Background technique [0002] Walnut, also known as walnut, Qiang peach, long live seed, etc., is a plant of the genus Juglandaceae. At present, domestic research on walnuts is mainly based on dried walnuts. Although walnut processed products are gradually increasing, they are limited to walnut oil, walnut dew, walnut powder, amber walnut kernel and other products. The dry weight of protein in walnut accounts for 14-28%, which is a kind of high-quality plant protein resource. Walnut peptide, as an enzymatic hydrolysis extract of walnut dregs, contains 18 kinds of amino acids, including 8 kinds of essential amino acids for human body, and also contains more brain-building substances-aspartic acid, glutamic acid, arginine, etc., which have anti-inflammatory properties. Oxidation, antibacterial, ACE inhib...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23P10/30A23L33/18A23L29/30A23L29/00A23P20/10
CPCA23V2002/00A23L29/015A23L29/03A23L29/30A23L33/18A23P10/30A23P20/10A23V2200/30A23V2200/32
Inventor 肖俊勇从仁怀刘卫许琦马方励马忠华
Owner INFINITUS (CHINA) CO LTD