Preparation method of reduction response type nano material for coating and loading antitumor drug

An anti-tumor drug and nanomaterial technology, which is applied in the field of preparation of reduction-responsive nanomaterials, can solve the problems of poor selectivity and water solubility of chemotherapeutic drugs, toxic and side effects, and reduced therapeutic effects, and achieves simple and fast assembly operation and improved dispersibility. Effect

Inactive Publication Date: 2018-07-24
HENAN NORMAL UNIV
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Problems solved by technology

[0002] Tumor is one of the major diseases that threaten human health in my country. At present, chemotherapy is the most effective method to treat tumors clinically. However, the selectivity and water solubility of chemotherapy...

Method used

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  • Preparation method of reduction response type nano material for coating and loading antitumor drug
  • Preparation method of reduction response type nano material for coating and loading antitumor drug
  • Preparation method of reduction response type nano material for coating and loading antitumor drug

Examples

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Embodiment 1

[0040] (1) MPEG 1.9K -Synthesis of Br:

[0041]

[0042] MPEG 1.9K -Synthesis of Br:

[0043] 5.006 g dry MPEG 1.9k (2.632mmol hydroxyl) was dissolved in 40mL of anhydrous tetrahydrofuran, 1.20mL (8.421mmol) of triethylamine was added, and 1.02mL of 2-bromoisobutyryl bromide (7.895mmol) was added dropwise under ice-water bath and vigorous stirring ([OH]:[Br]:[triethylamine]=1:3:3.2). After adding the acid bromide, react at 0°C for 0.5h, then react at room temperature for 12h, then raise the temperature to 20°C and 35°C to continue the reaction for 12h respectively. The residue was dissolved with a small amount of dry dichloromethane and precipitated in ether. The obtained crude product was dissolved twice, filtered and precipitated, and then dried in vacuum at 35°C to obtain the product, which was labeled as MPEG 1.9K -Br.

[0044] MPEG 5K -Synthesis of Br:

[0045] Composite MPEG 5K The quantities of medicines and reagents required for -Br are as follows: Dry MPEG...

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Abstract

The invention aims at solving the technical problem of providing a preparation method of a reduction response type nano material for coating and loading an antitumor drug. An HNTs (Halloysite Nanotubes)-polymer nano composite material is formed through carrying out covalent modification on the surfaces of HNTs by using a silane coupling agent and connecting up a disulfide bond containing nanotubewith an amino group at a terminal and meanwhile, through the electrostatic interaction between the amino group at the terminal of the nanotube and a carboxyl group at the terminal of a block copolymerPEO-b-PAA (Polyethylene Oxide-b-Polyacrylic Acid). The reduction response type nano material can be used for a carrier of the antitumor drug by adding a redox-response radical disulfide bond during design, and meanwhile, realizes enabling a the drug carrier to be capable of maintaining long-range circulation in vivo and to quickly release a drug at a diseased region. The stable cross-linked structure of the micelle of a polymer can be used for improving the stability of the micelle, and can be used for enhancing the stability of the drug when serving as the drug carrier; the micelle based onthe disulfide bond can be used for achieving the release, at a tumor region, of the drug, and the treatment effect is improved.

Description

technical field [0001] The invention belongs to the technical field of preparation of nano-drug carriers, and in particular relates to a preparation method of reduction-responsive nano-materials for carrying anti-tumor drugs. Background technique [0002] Tumor is one of the major diseases that threaten human health in my country. At present, chemotherapy is the most effective method to treat tumors clinically. However, the selectivity and water solubility of chemotherapy drugs are poor, and they have toxic side effects. Can kill normal tissue cells. In addition, the insensitivity of many tumor cells to chemotherapeutic drugs and their inherent multidrug resistance further reduce the therapeutic effect. [0003] Nano-drug carriers have attracted people's attention because of their characteristics of targeting, specificity, fast absorption, accurate quantification, high drug loading capacity, controllable drug release rate, prolonged drug action time and improved drug stabili...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/34A61K47/02A61K31/704A61P35/00
CPCA61K9/1075A61K31/704A61K47/02A61K47/34
Inventor 喻永杰胡志国王小坤赵沙沙
Owner HENAN NORMAL UNIV
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