Preparation method of polysubstituted pyrrole compound

A compound and multi-substitution technology, which is applied in the field of preparation of multi-substituted pyrrole compounds, can solve the problems of severe conditions and poor chemical selectivity, and achieve the effects of high reactivity, wide application range and high yield
CN108358933AInactive Publication Date: 2018-08-03SOUTH CHINA UNIV OF TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2018-08-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of a polysubstituted pyrrole compound. The preparation method comprises steps as follows: an alkyne enamine compound is subjected to a cyclization reactionunder the catalytic action of univalent gold, a product is subjected to column chromatography or recrystallization separation, and a fully substituted pyrrole compound is obtained; substituent groupscan be removed from the pyrrole compound under the proper condition, and a tetra-substituted pyrrole compound is obtained. The chain-like alkyne enamine compound is subjected to the cyclization reaction, and the fully substituted or tetra-substituted pyrrole compound is obtained. The preparation method has the advantages that the operation is simple, steps are simple, the reaction is efficient, raw materials are cheap and easy to obtain, the pilot plant test can be amplified and the like.
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Description

technical field

[0001] The invention relates to the field of synthesis of pyrrole compounds, in particular to a preparation method of multi-substituted pyrrole compounds. Background technique

[0002] Pyrrole and its derivatives are widely used in the organic synthesis industry, and are important raw materials or key intermediates of fine chemicals such as pharmaceuticals, pesticides, and spices. Compounds containing pyrrole structural units widely exist in nature. Due to their special structure, they show important biological activities. Many natural products or drug molecules contain pyrrole units. [1] . (Document 1: (a) Paris, D.; Cottin, M.; Demonchaux, P.; Augert, G.; Dupassieux, P.; Lenoir, P.; Peck, M.J.; Jasserand, D.J.Med.Chem.1995, 38,669; (b) Fernandez, L.S.; Buchanan, M.S.; Caroll, A.R.; , T.; Yasue, K.; Matsumoto, K.; Kajimoto, Y.; Ogo, T.; Inaba, T. Org. Lett. 2007, 9, 3331; (d) Wilson, R.M.; , R.G.; Ellman, J.A.Org.Lett.2006, 8, 1745; (e) Schrader, T.O.; J...

Claims

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