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Wound dressing

A wound surface and sodium alginate technology, applied in the field of sanitary materials, can solve the problems of wound surface mechanical damage, poor exudate absorption ability, uncomfortable observation of wound surface, etc., and achieve the effect of strong physical strength and strong affinity

Active Publication Date: 2018-08-24
SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing wound dressings have poor ability to absorb exudate, which is easy to cause cross-infection; or are easy to adhere to the wound surface, and may easily cause mechanical damage to the wound surface when replaced; or have poor strength, and are easy to fall off from the wound surface; or are easily eroded by gastric juice; or transparency Low, not suitable for observing the wound surface; therefore, it is the technology in the art to produce a wound dressing that can quickly absorb moisture, blood, exudate and other liquids on the surface of the wound surface to form a gel protective layer, and has strong elasticity, good viscosity, and gastric acid erosion resistance. Problems that people need to solve

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: the evaluation of different prescription gel tensile strength

[0072] Add the raw materials of each group shown in Table 1 into the boiling granulator preheated at 70°C, the molecular weight of hydroxyethyl starch is 135,000 Da, the molecular weight of sodium alginate is 6000 Da, the G / M ratio is 1.50, and the molecular weight of alginic acid The particle size of sodium and hydroxyethyl starch is 40 mesh. Start the fan of the boiling granulator at a wind speed of 60HZ to make the hydroxyethyl starch, sodium alginate, and calcium chloride boil in a fluidized state, add 50g of deionized water to the boiling granulator through the spray gun for granulation, and control the spraying of the spray gun The motor speed is 200rpm, the pressure is 0.2MPa, the wind speed is 75HZ, the inlet temperature is 70°C, the outlet temperature is 40°C, and the boiling granulation time is 10min. Pack and seal the granulated wound dressing, put it into a sterilizer, inject ethy...

Embodiment 2

[0086] Example 2: Effect of the ratio of G / M in sodium alginate on the tensile strength of the gel

[0087] Sodium alginate 800g, hydroxyethyl starch 400g and calcium chloride 10g, the molecular weight of hydroxyethyl starch is 220,000 Da, the molecular weight of sodium alginate is 6000 Da, the particle size of sodium alginate and hydroxyethyl starch is 40 mesh, it is suitable for seaweed The ratio of β-D-guluronic acid (G) to α-L-mannuronic acid (M) in sodium nitrate is adjusted, and the preparation method is as shown in Example 1.

[0088] Swell 1.0 g of each formulation sample in 10.0 g of water to form a gel, and measure the gel strength with an extensional rheometer. The results are shown in Table 3.

[0089] table 3

[0090] Sample serial number

[0091] The test results show that the ratio of β-D-guluronic acid (G) to α-L-mannuronic acid (M) in sodium alginate has a great influence on the strength of the gel, and the ratio of G / M is too low The formed gel ha...

Embodiment 3

[0092] Example 3: Effect of particle size on water absorption time and water absorption

[0093] Sodium alginate 800g, hydroxyethyl starch 400g and calcium chloride 10g, the molecular weight of hydroxyethyl starch is 135,000 Da, the molecular weight of sodium alginate is 6000 Da, β-D-guluronic acid (G) in sodium alginate The ratio to α-L-mannuronic acid (M) is 2.0, the particle size of sodium alginate is adjusted, and the preparation method is as shown in Example 1.

[0094] Sprinkle 1g of the sample evenly in a petri dish filled with 40g of water. The diameter of the petri dish is 9cm. After 30s, take out the gel, weigh it, and calculate the weight of the water absorbed by the sample. The results are shown in Table 4.

[0095] Table 4

[0096] Sample serial number

[0097]The test results show that: when the particle size of sodium alginate is within 40-120 mesh, it can quickly absorb water to form a gel, and the water absorption per gram of sample is greater than ...

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Abstract

The invention discloses a wound dressing. The wound dressing comprises hydroxyethyl starch with the molecular weight of 100,000-700,000 Da. The wound dressing is prepared from, in parts by weight, 20-80 parts of sodium alginate, 20-80 parts of hydroxyethyl starch and 0-5 parts of calcium chloride. The wound dressing can rapidly absorb water, blood, effusion and other liquids on the surface of a wound to form a gel protection layer and stays on the wound for 7 d or longer; influence of wound bleeding on an operation can be reduced, cleanness of the operation view field is kept, and the operation can be performed smoothly; the wound dressing can pack tissue to prevent contact of helicobacter pylori and other pathogenic microorganisms with the wound and prevent infection, and application ofantibiotics is reduced; the wound dressing can be applied to the wound of a gastrointestinal mucous membrane, effectively resist attack and erosion of gastric acid, pepsin and other attack factors tothe wound; the wound dressing can effectively stimulate the gastrointestinal tract to promote increase of activities of the gastrointestinal tract and recover the movement function of the gastrointestinal tract.

Description

technical field [0001] The invention relates to the technical field of hygienic materials, in particular to a wound dressing. Background technique [0002] After digestive tract surgery, wounds and wounds are usually directly exposed on the surface of the digestive tract, and are stimulated by bacteria, gastric acid, digestive enzymes and other harmful substances, which will increase the difficulty of healing. In addition, in order to prevent infection, a large amount of antibiotics are usually injected or taken after surgery, which can easily lead to the abuse of antibiotics and the emergence of drug-resistant strains, thereby forming a vicious circle of antibiotic abuse and increasing the medical burden. [0003] In recent years, in order to promote the rapid healing of wounds, various wound dressings have emerged, which can be divided into traditional dressings, biological dressings, synthetic dressings and growth factor dressings according to their materials. These woun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L31/04A61L31/02A61L31/14
CPCA61L26/0004A61L26/0023A61L26/0061A61L31/028A61L31/042A61L31/14C08L5/04C08L3/08
Inventor 杜武华林栋青林艳华李焱尹翠竹高领邱新林刁盈盈
Owner SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD
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