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A kind of sulforaphane pickering microemulsion and preparation method thereof

A technology of sulforaphane and microemulsion, which is applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve the problems of deteriorating product use experience, astringent hand feeling, etc., achieve improved stability, not easy to break, and improve drug loading volume effect

Active Publication Date: 2019-11-22
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, diatomite, montmorillonite, and nanopolymer particles are all solid powders with high hardness and astringent feel, which will deteriorate the use experience of the product when used in cosmetics

Method used

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  • A kind of sulforaphane pickering microemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]A preparation method of sulforaphane pickering microemulsion, characterized in that the following steps are adopted:

[0038] A. Weigh raw materials according to the following mass ratio: 1.8% zein, 0.6% corn glycogen, 0.08% sodium chloride, 10.0% ethanol, 20.0% cyclopentasiloxane, 8.0% methylpyrrolidone , 4.0% sulforaphane, 8.0% isononyl isononanoate, 3.5% sea buckthorn fruit oil, 0.50% phenoxyethanol, and the balance is distilled water;

[0039] B. Put zein and ethanol into the emulsification pot, stir at 200rpm at room temperature until completely dissolved, then put in weighed distilled water and corn glycogen, stir at 300rpm at room temperature until completely dissolved, and finally add chloride sodium, phenoxyethanol to obtain an aqueous dispersion, and use a citric acid-sodium citrate buffer to adjust the pH of the aqueous dispersion to 7.0;

[0040] C. Add sulforaphane and methylpyrrolidone to the oil phase pot, stir and disperse, then add cyclopentasiloxane, i...

Embodiment 2

[0045] A preparation method of sulforaphane pickering microemulsion, characterized in that the following steps are adopted:

[0046] A. Weigh raw materials according to the following mass ratio: 1.2% zein, 0.3% corn glycogen, 0.02% sodium chloride, 5.0% ethanol, 12.0% cyclopentasiloxane, 10.5% methylpyrrolidone , 3.0% sulforaphane, 6.0% isononyl isononanoate, 2.5% avocado oil, 2.5% white pool flower seed oil, 0.50% phenoxyethanol, and the balance is distilled water;

[0047] B. Put zein and ethanol into the emulsification pot, stir at 100rpm at room temperature until completely dissolved, then put in weighed distilled water and corn glycogen, stir at 450rpm at room temperature until completely dissolved, and finally add chloride sodium, phenoxyethanol to obtain an aqueous dispersion, and use citric acid-sodium citrate buffer to adjust the pH value of the aqueous dispersion to 6.0;

[0048] C. Add sulforaphane and methylpyrrolidone to the oil phase pot, stir and disperse, then...

Embodiment 3

[0053] A preparation method of sulforaphane pickering microemulsion, characterized in that the following steps are adopted:

[0054] A. Weigh raw materials according to the following mass ratio: 2.5% zein, 0.5% corn glycogen, 0.12% sodium chloride, 15.0% ethanol, 25.0% cyclopentasiloxane, 12.5% ​​methylpyrrolidone , 5.0% sulforaphane, 3.0% isononyl isononanoate, 2.0% linseed oil, 0.50% phenoxyethanol, the balance is distilled water;

[0055] B. Put zein and ethanol into the emulsification pot, stir at 200rpm at room temperature until completely dissolved, then put in weighed distilled water and corn glycogen, stir at 350rpm at room temperature until completely dissolved, and finally add chloride sodium, phenoxyethanol to obtain an aqueous dispersion, and use a citric acid-sodium citrate buffer to adjust the pH of the aqueous dispersion to 6.5;

[0056] C. Add sulforaphane and methylpyrrolidone to the oil phase pot, stir and disperse, then add cyclopentasiloxane, isononyl ison...

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Abstract

The invention relates to a sulforaphane Pickering micro-emulsion and a preparation method thereof. The sulforaphane Pickering micro-emulsion is characterized by comprising, by mass percentage, 1.2-2.5% of zein, 0.3-0.6% of corn glycogen, 0.02-0.12% of sodium chloride, 5.0-15.0% of ethanol, 12.0-25.0% of cyclopentasiloxane, 4.8-13.5% of methyl pyrrolidone, 3.0-5.0% of sulforaphane, 3.0-8.0% of isononyl isononanoate, 2.0-5.0% of vegetable oil, 0.50% of phenoxyethanol and the balance distilled water. The prepared sulforaphane Pickering micro-emulsion is small in irritation, good in transdermal absorption, high in drug loading capacity, good in skin feeling and simple in preparation process.

Description

technical field [0001] The invention relates to the technical field of preparation of Pickering microemulsions, in particular to a sulforaphane Pickering microemulsion and a preparation method thereof. Background technique [0002] Sulforaphane (1-isothiocyanate-4-methylsulfonylbutane, Sulforaphane), also known as "sulforaphane", is mainly found in radish, cabbage, broccoli and other cruciferous plants, and has good Anti-cancer effect, it has anti-pollution and anti-oxidation effects in the cosmetic industry. Sulforaphane has strong activity and is easily affected by ambient temperature, light and pH value. It is easy to decompose, change color and taste at room temperature. At present, the research on improving the stability of sulforaphane in relevant literatures, such as the preparation method of a sulforaphane microemulsion quick-release drop pill reported in patent CN201710077085.7, the patent CN201210023702.2 reported a sulforaphane Microcapsule embedding methods, et...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/46A61K8/64A61K8/73A61K8/06A61Q19/00A61Q19/08
CPCA61K8/068A61K8/46A61K8/645A61K8/73A61K2800/413A61Q19/00A61Q19/08
Inventor 薛绘蒋丽刚杨盼盼毕永贤吕旭阳李昊
Owner PROYA COSMETICS