Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound albendazole suspension solution agent and preparation method thereof

A technology of albendazole and solution, which is applied in the field of compound albendazole suspension solution and its preparation, can solve the problems of single function and poor stability, and achieve uniform drug distribution, improved stability and convenient use Effect

Inactive Publication Date: 2018-09-14
JIANGXI NUCLEAR IND TIANDIHE PHARMA
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is to solve the technical problem of poor stability and single function of existing albendazole products, and provides a kind of compound albendazole suspension solution and preparation method thereof

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound albendazole suspension solution agent and preparation method thereof
  • Compound albendazole suspension solution agent and preparation method thereof
  • Compound albendazole suspension solution agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0018] Specific embodiment one: the compound recipe albendazole suspension solution of the present embodiment is made of albendazole, piperazine citrate, suspending agent, preservative, antioxidant, surfactant, propylene glycol, PBS damping fluid The suspension solution of composition, wherein contains albendazole 50~300g, piperazine citrate 10~100g, suspending agent 10~50g, preservative 5~50g in the compound albendazole suspension solution of every 1000mL 30g, antioxidant 10-30g, surfactant 10-50g, propylene glycol 50-100m, PBS buffer 100-200ml, and the rest is water.

specific Embodiment approach 2

[0019] Specific embodiment two: the difference between this embodiment and specific embodiment one is that a kind of replacement cost of conventional suspending agents such as gum arabic, agar, peach gum, sodium carboxymethyl cellulose, povidone in embodiment one The suspending agent in the invention is the mixture of polyvinyl alcohol and magnesium stearate. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0020] In this embodiment, polyvinyl alcohol is also a kind of stabilizer and synthetic polymer slow-release material except that there is a suspending agent effect, which strengthens the effect of the compound albendazole suspension, making the compound albendazole suspension The agent is not easy to stratify, and has a certain sustained-release effect. Simultaneously, it can also effectively stabilize the active ingredient content and prevent the deterioration of the compound albendazole suspension solution. Specific embodiment three: what this embodiment is different from specific embodiment one or two is that conventional antiseptic is phenol, sorbic acid, potassium sorbate, benzoic acid, sodium benzoate, methylparaben, ethylparaben , propylparaben, butylparaben, benzyl alcohol, phenylethyl alcohol, citric acid, sodium citrate or a mixture of the above-mentioned multiple forms in any proportion, replace the preservatives in the present invention, i.e. thimerosal and A mix...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to veterinary vermifuges and preparation methods thereof, in particular to a compound albendazole suspension solution agent and a preparation method thereof, and is intended to solve the technical problem that existing albendazole products have single function. The compound albendazole suspension solution agent is composed of albendazole, piperazine citrate, a suspending aid,a preservative, an antioxidant, a surfactant, propylene glycol, PBS (phosphate buffered solution) and water. The piperazine citrate is used herein to achieve synergy for albendazole, so that parasiteexpelling effect of albendazole is enhanced. The process that is already optimized is utilized; albendazole is suspended in the suspending aid first; the PBS is used then to adjust pH value so that the piperazine citrate precipitates out fully and suspends in the solution; the two drugs are processed into particulate suspension through a high-speed shear mixing emulsification machine, and the compound albendazole suspension solution agent having the particle size of < / =0.1 mu m is obtained. The compound albendazole suspension solution agent has good stability and is suitable for killing gastrointestinal nematodes, lungworms and hemoflagellate protozoa in livestock, poultry or pets.

Description

technical field [0001] The invention relates to a preparation method of a veterinary drug preparation, in particular to a compound albendazole suspension solution and a preparation method thereof. Background technique [0002] With the development of animal husbandry, pigs, cattle, sheep, chickens and other animals are intensively raised. Under such intensive feeding conditions, parasitic diseases are more likely to develop and spread. Therefore, it is particularly important to get rid of parasites in animals and promote healthy growth of animals. There are many varieties of veterinary anthelmintics on the market now. [0003] Albendazole is a broad-spectrum anthelmintic drug of imidazole derivatives. Albendazole is a broad-spectrum anthelmintic with high efficiency and low toxicity. Clinically, it can be used to drive away roundworms, pinworms, tapeworms, whipworms, hookworms, and strongyloid nematodes. After being metabolized into sulfoxides or sulfones in the body, it...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/4184A61K31/495A61K47/32A61K47/20A61K47/04A61K47/02A61P33/10A61P33/14A61P33/02
CPCA61K9/10A61K31/4184A61K31/495A61K47/02A61K47/20A61K47/32A61P33/02A61P33/10A61P33/14A61K2300/00
Inventor 李龙瑞张庆生孔晟张吉鹍陈金兴赖贻奎邵智军李检香鄢涛周奀忠何中华杨志明朱斌
Owner JIANGXI NUCLEAR IND TIANDIHE PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com