Compound albendazole suspension solution agent and preparation method thereof
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A technology of albendazole and solution, which is applied in the field of compound albendazole suspension solution and its preparation, can solve the problems of single function and poor stability, and achieve uniform drug distribution, improved stability and convenient use Effect
Inactive Publication Date: 2018-09-14
JIANGXI NUCLEAR IND TIANDIHE PHARMA
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Problems solved by technology
[0004] The present invention is to solve the technical problem of poor stability and single function of existing albendazole products, and provides a kind of compound albendazole suspension solution and preparation method thereof
Method used
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specific Embodiment approach 1
[0018] Specific embodiment one: the compound recipe albendazole suspension solution of the present embodiment is made of albendazole, piperazine citrate, suspending agent, preservative, antioxidant, surfactant, propylene glycol, PBS damping fluid The suspension solution of composition, wherein contains albendazole 50~300g, piperazine citrate 10~100g, suspending agent 10~50g, preservative 5~50g in the compound albendazole suspension solution of every 1000mL 30g, antioxidant 10-30g, surfactant 10-50g, propylene glycol 50-100m, PBS buffer 100-200ml, and the rest is water.
specific Embodiment approach 2
[0019] Specific embodiment two: the difference between this embodiment and specific embodiment one is that a kind of replacement cost of conventional suspending agents such as gum arabic, agar, peach gum, sodium carboxymethyl cellulose, povidone in embodiment one The suspending agent in the invention is the mixture of polyvinyl alcohol and magnesium stearate. Others are the same as in the first embodiment.
specific Embodiment approach 3
[0020] In this embodiment, polyvinyl alcohol is also a kind of stabilizer and synthetic polymer slow-release material except that there is a suspending agent effect, which strengthens the effect of the compound albendazole suspension, making the compound albendazole suspension The agent is not easy to stratify, and has a certain sustained-release effect. Simultaneously, it can also effectively stabilize the active ingredient content and prevent the deterioration of the compound albendazole suspension solution. Specific embodiment three: what this embodiment is different from specific embodiment one or two is that conventional antiseptic is phenol, sorbic acid, potassium sorbate, benzoic acid, sodium benzoate, methylparaben, ethylparaben , propylparaben, butylparaben, benzyl alcohol, phenylethyl alcohol, citric acid, sodium citrate or a mixture of the above-mentioned multiple forms in any proportion, replace the preservatives in the present invention, i.e. thimerosal and A mix...
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Abstract
The invention relates to veterinary vermifuges and preparation methods thereof, in particular to a compound albendazole suspension solution agent and a preparation method thereof, and is intended to solve the technical problem that existing albendazole products have single function. The compound albendazole suspension solution agent is composed of albendazole, piperazine citrate, a suspending aid,a preservative, an antioxidant, a surfactant, propylene glycol, PBS (phosphate buffered solution) and water. The piperazine citrate is used herein to achieve synergy for albendazole, so that parasiteexpelling effect of albendazole is enhanced. The process that is already optimized is utilized; albendazole is suspended in the suspending aid first; the PBS is used then to adjust pH value so that the piperazine citrate precipitates out fully and suspends in the solution; the two drugs are processed into particulate suspension through a high-speed shear mixing emulsification machine, and the compound albendazole suspension solution agent having the particle size of < / =0.1 mu m is obtained. The compound albendazole suspension solution agent has good stability and is suitable for killing gastrointestinal nematodes, lungworms and hemoflagellate protozoa in livestock, poultry or pets.
Description
technical field [0001] The invention relates to a preparation method of a veterinary drug preparation, in particular to a compound albendazole suspension solution and a preparation method thereof. Background technique [0002] With the development of animal husbandry, pigs, cattle, sheep, chickens and other animals are intensively raised. Under such intensive feeding conditions, parasitic diseases are more likely to develop and spread. Therefore, it is particularly important to get rid of parasites in animals and promote healthy growth of animals. There are many varieties of veterinary anthelmintics on the market now. [0003] Albendazole is a broad-spectrum anthelmintic drug of imidazole derivatives. Albendazole is a broad-spectrum anthelmintic with high efficiency and low toxicity. Clinically, it can be used to drive away roundworms, pinworms, tapeworms, whipworms, hookworms, and strongyloid nematodes. After being metabolized into sulfoxides or sulfones in the body, it...
Claims
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