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Magnesium alloy fixing screw capable of being degraded under control in vivo

A technology for fixing screws and magnesium alloys, applied in the field of medical devices, can solve the problems of reducing the mechanical properties and stability of materials, increasing the pH value, and low electrode potential

Active Publication Date: 2018-09-18
申英末 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the standard electrode potential of magnesium is very low, especially Cl in body fluid - It will accelerate the corrosion of magnesium alloys, and the rapid degradation rate will lead to serious corrosion of the implanted materials before the body heals, reducing the mechanical properties and stability of the materials, and the rapid corrosion of magnesium alloys will not only be accompanied by a large amount of hydrogen release , and the too fast degradation rate will increase the local pH value of the body fluid near the implant, which will cause harm to the growth of human bones and group leaders, thus seriously restricting the clinical application of magnesium alloys.

Method used

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  • Magnesium alloy fixing screw capable of being degraded under control in vivo
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  • Magnesium alloy fixing screw capable of being degraded under control in vivo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Select the WE43A magnesium alloy screw body with a length of 5 mm, use sandpaper grinding and ultrasonic cleaning to remove oxides and impurities on the surface, then soak it in 50 g / L NaOH solution for 10 minutes, take it out, wash it and dry it. Then perform alternating current oxidation treatment in the oxidation treatment solution to form an oxide film layer with a thickness of about 50 μm. The composition of the oxidation treatment liquid is: 20g / L oxalic acid, 2.2g / L calcium nitrate, 1.8g / L potassium fluoride, 2.5g / L magnesium silicate and the balance water. The temperature of the oxidation treatment solution is 10°C, and the current density is 0.10A / dm 2 , the oxidation treatment time is 2 hours. Then dip in a 1.0 mg / L poly-L-lactide (PLLA) solution for 20 minutes, take it out and dry to obtain a poly-L-lactide coating with a thickness of about 10 μm.

Embodiment 2

[0023] Select the WE43A magnesium alloy screw body with a length of 5 mm, use sandpaper grinding and ultrasonic cleaning to remove oxides and impurities on the surface, then soak it in 50 g / L NaOH solution for 10 minutes, take it out, wash it and dry it. Then perform alternating current oxidation treatment in the oxidation treatment solution to form an oxide film layer with a thickness of about 50 μm. The composition of the oxidation treatment liquid is: 32g / L citric acid, 1.8g / L calcium nitrate, 1.2g / L potassium fluoride, 3.0g / L magnesium silicate and the balance water. The temperature of the oxidation treatment solution is 10°C, and the current density is 0.10A / dm 2 , the oxidation treatment time is 2 hours. Then dip in a 1.0 mg / L poly-L-lactide (PLLA) solution for 20 minutes, take it out and dry to obtain a poly-L-lactide coating with a thickness of about 10 μm.

Embodiment 3

[0025] Select the WE43A magnesium alloy screw body with a length of 5 mm, use sandpaper grinding and ultrasonic cleaning to remove oxides and impurities on the surface, then soak it in 50 g / L NaOH solution for 10 minutes, take it out, wash it and dry it. Then perform alternating current oxidation treatment in the oxidation treatment solution to form an oxide film layer with a thickness of about 50 μm. The composition of the oxidation treatment liquid is: 20g / L oxalic acid, 2.2g / L calcium nitrate, 1.8g / L potassium fluoride, 2.5g / L magnesium silicate and the balance water. The temperature of the oxidation treatment solution is 10°C, and the current density is 0.10A / dm 2 , the oxidation treatment time is 2 hours. Then dip in a 1.0 mg / L polylactic acid (PLA) solution for 20 minutes, take it out and dry to obtain a polylactic acid coating with a thickness of about 10 μm.

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Abstract

The invention relates to a magnesium alloy fixing screw capable of being degraded under control in vivo, belonging to the technical field of medical instruments. The magnesium alloy fixing screw capable of being degraded under control in vivo comprises a magnesium alloy screw body on which an oxidation film layer with a thickness of 50-200 microns is formed, and the oxidation film layer is coatedwith a degradable polymer coating with a thickness of 1-50 microns. The magnesium alloy fixing screw can be degraded under control in vivo, the strength maintaining period of the fixing screw is about3 months, the degradable period can be controlled within about 6-8 months, and the fixing screw is suitable for fixing between tissue and tissue or between the tissue and a patching material, and particularly suitable for repairing coloboma of soft tissue such as hernia.

Description

technical field [0001] The invention relates to the technical field of medical devices, and more specifically, the invention relates to a magnesium alloy fixing screw with controllable degradation in vivo. Background technique [0002] The fixation screw used in the body is a typical medical implant material. As a medical implant material, it needs to have good chemical stability, non-toxicity and good biological tissue adaptability. The first medical implant materials widely used in clinical treatment are precious metals such as gold, silver, and platinum, but their applications are limited due to their high prices. At present, metal implant materials widely used in clinical practice include titanium alloy, stainless steel and cobalt-chromium alloy. These metals have good corrosion resistance and can maintain structural stability for a long time in the body. However, the above alloys will produce toxic metal ions due to abrasion in the body. May cause allergic reaction or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/14A61L31/16
CPCA61L31/022A61L31/08A61L31/088A61L31/10A61L31/148A61L31/16A61L2420/02A61L2420/08A61L2420/06A61L2420/04C08L67/04
Inventor 申英末王威
Owner 申英末
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