Fluconazole tablets and preparation method thereof

A fluconazole tablet and the fluconazole tablet technology are applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve the problem of poor compressibility and friability of dispersible tablets. , the dissolution rate and bioavailability are not high, the tablet is easily broken, etc., to achieve the effect of stable appearance, high bioavailability and good stability

Inactive Publication Date: 2018-09-28
TIANJIN PHARMA GROUP XINZHENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fluconazole tablet of the present application is limited by conditions such as technology, technology, and equipment during the tableting process, so that the compressibility and friability of the dispersible tablet are relatively poor, and the tablet is also easily broken during the packaging process; Moreover, although this solution improves the disintegration rate, the dissolution rate and bioavailability are not high

Method used

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  • Fluconazole tablets and preparation method thereof
  • Fluconazole tablets and preparation method thereof
  • Fluconazole tablets and preparation method thereof

Examples

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Effect test

Embodiment 1

[0029] The oval fluconazole tablet of the present invention is composed of the following raw materials in parts by weight: 40 parts of fluconazole, 0.1 part of sodium alginate, 5 parts of anhydrous calcium hydrogen phosphate, 10 parts of microcrystalline cellulose, croscarmellose 2 parts of sodium cellulose, 5 parts of povidone K30, and 0.2 parts of magnesium stearate.

[0030] The preparation method of above-mentioned fluconazole tablet comprises the steps:

[0031] 1) Grind the raw and auxiliary materials in the prescription separately and pass through a 50-mesh sieve for later use;

[0032] 2) Weigh the raw and auxiliary materials in step 1) according to the prescription amount, take 2.5 parts of croscarmellose sodium, and then stir evenly;

[0033] 3) Then use purified water (the amount is 20% of the total mass of the prescription) to mix with the raw materials in step 2) evenly, the mixing time is 5 minutes, carry out wet granulation, pass through a 24-mesh sieve, and th...

Embodiment 2

[0036] The oval fluconazole tablet of the present invention is composed of the following raw materials in parts by weight: 50 parts of fluconazole, 5 parts of sodium alginate, 15 parts of anhydrous calcium hydrogen phosphate, 20 parts of microcrystalline cellulose, croscarmellose 15 parts of cellulose sodium, 10 parts of povidone K30, and 2 parts of magnesium stearate.

[0037] The preparation method of above-mentioned fluconazole tablet comprises the steps:

[0038] 1) Grind the raw and auxiliary materials in the prescription separately and pass through a 50-mesh sieve for later use;

[0039] 2) Weigh the raw and auxiliary materials in step 1) according to the prescription amount, take 5 parts of croscarmellose sodium, and then stir evenly;

[0040] 3) Then use ethanol (the amount is 40% of the total mass of the prescription) to mix with the raw materials in step 2) evenly, and the mixing time is 15 minutes, carry out wet granulation, pass through a 24-mesh sieve, and then d...

Embodiment 3

[0043] The oval fluconazole tablet of the present invention is composed of the following raw materials in parts by weight: 45 parts of fluconazole, 1.34 parts of sodium alginate, 10 parts of anhydrous calcium hydrogen phosphate, 15 parts of microcrystalline cellulose, croscarmellose 10 parts of sodium cellulose, 7 parts of povidone K30, and 1 part of magnesium stearate.

[0044] The preparation method of above-mentioned fluconazole tablet comprises the steps:

[0045] 1) Grind the raw and auxiliary materials in the prescription separately and pass through a 50-mesh sieve for later use;

[0046] 2) Weigh the raw and auxiliary materials in step 1) according to the prescription amount, take 5 parts of croscarmellose sodium, and then stir evenly;

[0047] 3) Then use ethanol (the amount is 20% of the total mass of the prescription) to mix with the raw materials in step 2) evenly, and the mixing time is 10 minutes, carry out wet granulation, pass through a 24 mesh sieve, and then ...

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Abstract

The invention belongs to the technical field of medicine preparations and particularly relates to fluconazole tablets and a preparation method thereof. The fluconazole tablets comprise the following raw materials in parts by weight: 40 to 50 parts of fluconazole, 15 to 40 parts of a filling agent, 2 to 15 parts of a disintegrating agent, 5 to 10 parts of an adhesive and 0.2 to 2 parts of a lubricant, wherein the filling agent comprises sodium alginate, microcrystalline cellulose and anhydrous calcium hydrogen phosphate; the disintegrating agent comprises croscarmellose sodium; the adhesive ispovidone K30; and the lubricant is magnesium stearate. The fluconazole tablets have the advantages of high compressibility, controllable friability and dissolubility, rapidness in disintegration, excellent stability and dissolution performance, high bioequivalence and high bioavailability.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a fluconazole tablet and a preparation method thereof, in particular to an oval fluconazole tablet. Background technique [0002] Deep mycoses are dangerous and can lead to death. Especially in recent years, the widespread use of broad-spectrum antibiotics, the destruction of the normal flora relationship between bacteria and fungi, the extensive use of corticosteroids, immunosuppressants, and anti-tumor drugs, the widespread use of organ transplantation and catheterization, some The emergence of immunodeficiency diseases, etc., and the extensive use of immunosuppressants will reduce the body's resistance to fungi, and increase the incidence and severity of deep mycoses. Malnutrition, infirmity, etc. are also susceptible to fungi, so There is an urgent need for anti-deep fungal drugs with high efficiency, low toxicity and good selectivity. [0003] Fluconazo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/36A61K31/4196A61P31/10
CPCA61K9/205A61K31/4196A61P31/10
Inventor 王瑞玲周遂成李俊霞白艳鹤
Owner TIANJIN PHARMA GROUP XINZHENG
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