Tooth desensitizer containing phosphosilicate glass as well as preparation method and application thereof

A technology of phosphosilicate glass and desensitizing agent, applied in the field of dental biomedical materials, can solve problems such as pH increase, unfavorable cell survival, and affecting ion release rate in materials, so as to stabilize pH value and improve compatibility Effect

Active Publication Date: 2018-10-09
华魁科技泰州有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these bioactive glasses contain higher silicon content and less phosphorus content, which will affect the release rate of ions in the material; moreover, these glasses will cause pH increase in body fluid

Method used

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  • Tooth desensitizer containing phosphosilicate glass as well as preparation method and application thereof
  • Tooth desensitizer containing phosphosilicate glass as well as preparation method and application thereof
  • Tooth desensitizer containing phosphosilicate glass as well as preparation method and application thereof

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preparation example Construction

[0040] The preparation method of the present invention will be further described in detail in conjunction with specific examples below. It should be understood that the following examples are only for illustrating and explaining the present invention, and should not be construed as limiting the protection scope of the present invention. All technologies realized based on the above contents of the present invention are covered within the scope of protection intended by the present invention.

[0041] The experimental methods used in the following examples are conventional methods unless otherwise specified; the reagents and materials used in the following examples can be obtained from commercial sources unless otherwise specified.

preparation example

[0043] The preparation method of the phosphosilicate glass used in the following examples can be obtained by referring to the method disclosed in the Chinese patent document ZL201010248059.4 or Biomed. Phys. Eng. Express 3 (2017) 045017. Exemplarily, the preparation method of the calcium phosphosilicate glass described in Example 1 is as follows:

[0044] Using a mixture of ethanol and water as a solvent, mix phytic acid, tetraethyl orthosilicate and calcium nitrate tetrahydrate to prepare a gel precursor sol solution (the mixing ratio is selected according to the material requirements), and place it at room temperature until the gel ;Aging at 60°C for 1 week, then take it out and bake it in an oven at 120°C to volatilize all the solvents in it, sinter the dried gel at a temperature of 400-700°C, and keep it warm at this sintering temperature After 1 hour, it was naturally cooled to obtain a calcium phosphosilicate glass.

[0045] The content of calcium oxide in the calcium p...

Embodiment 1

[0048] A preparation of a tooth desensitizing agent containing calcium phosphosilicate glass-gelatin-phosphate buffer solution, the steps are as follows:

[0049] (1) Preparation of gelatin-phosphate buffer solution: Dissolve 0.5 g of gelatin in 10 mL of deionized water and heat at 60° C. for 30 min, add 10 mL of phosphate buffer, and dissolve to obtain gelatin-phosphate buffer.

[0050] (2) Preparation of desensitizing agent: Stir and mix the calcium phosphosilicate glass with the gelatin-phosphate buffer solution in step (1) at a ratio of 1:10 (g / mL) to obtain the tooth desensitizing agent.

[0051] Wherein, the content of calcium oxide in the calcium phosphosilicate glass is 29wt%, the content of silicon oxide is 48wt%, and the content of phosphorus oxide is 23wt%.

[0052] The prepared tooth desensitizing agent is coated on the surface of the dentin layer ( image 3 ), it was found that the dentinal tubules were almost completely closed.

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Abstract

The invention belongs to the technical field of a dental biological medical material and particularly relates to a tooth desensitizer containing phosphosilicate glass as well as a preparation method and application thereof. After the phosphosilicate glass is contacted with a phosphate buffer solution, artificial saliva or simulated body fluid, phosophate ions as well as calcium, strontium, magnesium, zinc, potassium or sodium ions can be released rapidly, a SiO2-enriched silica gel layer is formed on the surface of a material, Ca<2+> and PO4<3-> form a CaO-P2O5 amorphous layer on the SiO2 silica gel layer and the CaO-P2O5 amorphous layer is crystallized to be transformed into hydroxyapatite (HA), so that a dentinal tubule is rapidly closed and hemodia is treated. After the phosphosilicateglass and composite resin are compounded, the phosphosilicate glass is rapidly photocured through photo-initiated polymerization curing to cover the surface of a tooth, so that the dentinal tubule canbe closed rapidly and the hemodia is treated. The tooth desensitizer can block the dentinal tubule rapidly and effectively and induce a dentin layer to be rapidly repaired.

Description

technical field [0001] The invention belongs to the technical field of dental biomedical materials, and in particular relates to a tooth desensitizing agent containing phosphosilicate glass with high dissolution and stable pH value, its preparation method and application. Background technique [0002] Dentin hypersensitivity refers to a sharp, short-term sore symptom that occurs when exposed dentin is exposed to external stimuli (such as mechanical, chemical, temperature, permeability or airflow), and is a common dental hard tissue disease. . The theory of fluid dynamics believes that after the dentin is exposed, the dentinal tubules are opened, and when external stimuli act on the exposed dentine, the liquid in the dentinal tubules will flow rapidly inward or outward, thereby causing the nerve fibers of the dental pulp to be excited. produce pain. Therefore, the effective way to treat dentin hypersensitivity is to seal the dentin tubules and restore the dentin layer. [...

Claims

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Application Information

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IPC IPC(8): A61K6/00A61K6/02A61K6/027A61K6/033A61K6/097A61K6/838A61K6/898
CPCA61K6/20A61K6/80A61K6/836A61K6/838A61K6/898C08L5/08
Inventor 邱东李爱玲
Owner 华魁科技泰州有限公司
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