Preparation method of 2,4,6-triiodoresorcinol

Abstract

The invention relates to the technical field of drug synthesis, in particular to a preparation method of 2,4,6-triiodoresorcinol. The preparation method of the 2,4,6-triiodoresorcinol comprises the following steps: in a sulfuric acid methanol solution, taking resorcinol as a substrate and taking potassium iodide as an iodo-reagent, dropwise adding a hydrogen peroxide aqueous solution, and reactinghigh-activity new atomic iodine which is generated by oxidizing the potassium iodide through hydrogen peroxide with the resorcinol to produce the product. By-products are water and inorganic salt. The method for synthesizing iodophenol is an oxidizing iodination process, in the process, the generated high-activity iodinating agent-iodine chloride is generated in real time, iodination consumptionis implemented in real time, and the by-products of reaction is water and potassium sulphate; and reaction is green, effective, safe and controllable.

Description

technical field

[0001] The invention relates to the technical field of drug synthesis, and the specific field is a preparation method of iodophenol. Background technique

[0002] Iodophenol is 2,4,6-triiodoresorcine (2,4,6-Triiodoresorcine), which is white fine needle-like crystals. The interest of researchers has generated a lot of research work. Iodine powder has a good inhibitory effect on herpes virus, Microsporum, Candida albicans, Staphylococcus aureus and Corynebacterium diphtheriae, and is a broad-spectrum, antiviral drug. Many diseases are often induced by microorganisms and accompanied by viral and fungal infections, so the therapeutic effect of iodophenol is better than other single-acting drugs.

[0003] During the treatment process, iodophenol is non-irritating to the skin and has extremely low toxicity, and its production process has mild reaction conditions and stable yield. Now the production of iodophenol has also formed a certain scale industry. In addi...

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