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Preparation method of controlled degradable magnesium alloy fixing screw in vivo

A technology for fixing screws and magnesium alloys, applied in the field of medical devices, can solve problems such as restricting the application of magnesium alloys, low electrode potential, and accelerating corrosion of magnesium alloys.

Active Publication Date: 2018-10-30
申英末 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the standard electrode potential of magnesium is very low, especially C1 in body fluids - It will accelerate the corrosion of magnesium alloys, and the rapid degradation rate will lead to serious corrosion of the implanted materials before the body heals, reducing the mechanical properties and stability of the materials, and the rapid corrosion of magnesium alloys will not only be accompanied by a large amount of hydrogen release , and the too fast degradation rate will increase the local pH value of the body fluid near the implant, which will cause harm to the growth of human bones and group leaders, thus seriously restricting the clinical application of magnesium alloys.

Method used

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  • Preparation method of controlled degradable magnesium alloy fixing screw in vivo
  • Preparation method of controlled degradable magnesium alloy fixing screw in vivo
  • Preparation method of controlled degradable magnesium alloy fixing screw in vivo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Choose a WE43A magnesium alloy screw body with a length of 5mm and a diameter of 0.5mm. Use sandpaper to polish and ultrasonically clean the surface to remove oxides and impurities, then soak in 50g / L NaOH solution for 10 minutes, take it out, and wash and dry. Then, an alternating current oxidation treatment is performed in an oxidation treatment solution to form an oxide film layer with a thickness of about 50 μm. The composition of the oxidation treatment liquid was 20 g / L oxalic acid, 2.2 g / L calcium nitrate, 1.8 g / L potassium fluoride, 2.5 g / L magnesium silicate, and the balance of water. The temperature of the oxidation treatment solution is 10℃, and the current density is 0.10A / dm 2 , The oxidation treatment time is 2 hours. Then it was immersed in a 1.0 mg / L poly-L-lactide (PLLA) solution for 20 minutes, taken out and dried to obtain a poly-L-lactide coating with a thickness of about 10 μm.

Embodiment 2

[0024] Choose a WE43A magnesium alloy screw body with a length of 5mm and a diameter of 0.5mm. Use sandpaper to polish and ultrasonically clean the surface to remove oxides and impurities, then soak in 50g / L NaOH solution for 10 minutes, take it out, and wash and dry. Then, an alternating current oxidation treatment is performed in an oxidation treatment solution to form an oxide film layer with a thickness of about 50 μm. The composition of the oxidation treatment liquid was: 32 g / L of citric acid, 1.8 g / L of calcium nitrate, 1.2 g / L of potassium fluoride, 3.0 g / L of magnesium silicate, and the balance of water. The temperature of the oxidation treatment solution is 10℃, and the current density is 0.10A / dm 2 , The oxidation treatment time is 2 hours. Then it was immersed in a 1.0 mg / L poly-L-lactide (PLLA) solution for 20 minutes, taken out and dried to obtain a poly-L-lactide coating with a thickness of about 10 μm.

Embodiment 3

[0026] Choose a WE43A magnesium alloy screw body with a length of 5mm and a diameter of 0.5mm. Use sandpaper to polish and ultrasonically clean the surface to remove oxides and impurities, then soak in 50g / L NaOH solution for 10 minutes, take it out, and wash and dry. Then, an alternating current oxidation treatment is performed in an oxidation treatment solution to form an oxide film layer with a thickness of about 50 μm. The composition of the oxidation treatment liquid was 20 g / L oxalic acid, 2.2 g / L calcium nitrate, 1.8 g / L potassium fluoride, 2.5 g / L magnesium silicate, and the balance of water. The temperature of the oxidation treatment solution is 10℃, and the current density is 0.10A / dm 2 , The oxidation treatment time is 2 hours. Then, it is immersed in a 1.0 mg / L polylactic acid (PLA) solution for 20 minutes, taken out and dried to obtain a polylactic acid coating with a thickness of about 10 μm.

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Abstract

The invention relates to a preparation method of a controlled degradable magnesium alloy fixing screw in vivo and belongs to the technical field of medical apparatus and instruments. The preparation method of the controlled degradable magnesium alloy fixing screw in vivo comprises the following steps: firstly, processing a screw body by using magnesium alloy; secondly, forming an oxidation film layer with the thickness of 50 to 200mu m through the alternating current oxidation technology on the magnesium alloy screw body; thirdly, carrying out dip-coating or spraying of a biodegradable polymercoating which has the thickness of 1 to 50mu m on the oxidation film layer. The magnesium alloy fixing screw disclosed by the invention can be controlled and degraded in vivo; in addition, the strength retention period of the fixing screw is about 3 months and the degradation period can be controlled at about 6 to 8 months, so that the magnesium alloy fixing screw is suitable for fixing tissues or tissues and repair materials, and is especially suitable for repairing soft tissue defects such as hernia.

Description

Technical field [0001] The present invention relates to the technical field of medical devices. More specifically, the present invention relates to a method for preparing a magnesium alloy fixing screw that can be controlled and degraded in vivo. Background technique [0002] The fixation screw used in the body is a typical medical implant material. As a medical implant material, it needs to have good chemical stability, non-toxicity and good biological tissue adaptability. The first medical implant materials widely used in clinical treatment were precious metals such as gold, silver, and platinum, but their application was limited due to their higher prices. Metal implant materials currently widely used in clinical practice include titanium alloys, stainless steels, and cobalt-chromium alloys. These metals have good corrosion resistance and can maintain a long-term structural stability in the body. However, the above-mentioned alloys produce toxic metal ions due to abrasion in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/14A61L31/10A61L31/16
CPCA61L31/022A61L31/10A61L31/148A61L31/16A61L2430/34
Inventor 申英末王威
Owner 申英末
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