Barrier material, barrier film, preparation method and application thereof

A barrier material and barrier film technology, applied in the field of medical materials, can solve problems such as long operation time, long operation time, and inability to support stability

Active Publication Date: 2021-01-29
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to the risk of pathogen transmission itself, this kind of absorbable biofilm needs to fully consider the virus and immune elimination, and its products usually have poor mechanical properties after wetting and cannot support and maintain the stability of the covered space. In the process of use, cutting and suturing are required to combine with the surrounding tissue of the defect, which is cumbersome to operate, requires high surgical operation, and takes a long time to make the patient suffer more pain.
[0004] In summary, the barrier film formed by traditional barrier materials cannot have both sufficient mechanical strength and absorbable properties. When used in oral surgery, the operation is cumbersome, the operation is highly demanding, and the operation takes a long time.

Method used

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  • Barrier material, barrier film, preparation method and application thereof
  • Barrier material, barrier film, preparation method and application thereof
  • Barrier material, barrier film, preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0042] The flow chart of the preparation method of the barrier film of one embodiment is as follows figure 1 As shown, the barrier film is formed by the above barrier material, including the following steps S110-S120.

[0043] S110. Mix the modified hyaluronic acid, the modified mussel adhesion protein and the photoinitiator, wherein the modified hyaluronic acid includes hyaluronic acid and the first photocrosslinking agent grafted on the hyaluronic acid, and the modified The mussel adhesion protein includes the mussel adhesion protein and the second photocrosslinking agent grafted on the mussel adhesion protein.

[0044] Specifically, the first photocrosslinking agent can be grafted on hyaluronic acid through grafting reaction to obtain modified hyaluronic acid, and the second photocrosslinking agent can be grafted on mussel adhesion protein through grafting reaction to obtain modified hyaluronic acid. Modified mussel adhesion protein. The hyaluronic acid is grafted and mod...

Embodiment 1

[0064] Hyaluronic acid and glycidyl methacrylate were fed at a ratio of 8:1 for grafting reaction to prepare modified hyaluronic acid, and the grafting rate of glycidyl methacrylate was 3%. The reaction chemical formula is as follows:

[0065] .

[0066] The nuclear magnetic spectrum obtained by nuclear magnetic resonance (NMR) of the prepared modified hyaluronic acid is as follows: image 3 shown. Depend on image 3 It can be seen that glycidyl methacrylate has been grafted onto the hyaluronic acid. Observe the modified hyaluronic acid under a scanning electron microscope (SEM), and the magnification of 100× is as follows Figure 4 As shown, the multiples of 1000× are as Figure 5 shown. Depend on Figure 4 with Figure 5 It can be seen that the modified hyaluronic acid has a porous fiber structure, can absorb water, and has good hydrophilicity.

[0067] Recombinant mussel fibroin-151 (fp-151) was constructed by in vitro recombinant protein technology. The fp-151 u...

Embodiment 2

[0071] Hyaluronic acid and glycidyl methacrylate were fed at a ratio of 5:1 for grafting reaction to prepare modified hyaluronic acid, and the grafting rate of glycidyl methacrylate was 8%.

[0072] The recombinant mussel fibroin-151 (fp-151) was constructed by in vitro recombinant protein technology, and the recombinant mussel filaggrin-151 was modified to obtain a modified mussel adhesion with a catechol grafting rate of 3%. protein.

[0073] The ruthenium terpyridine and sodium persulfate were formulated into a photoinitiator mixed solution in a ratio of 1:2.

[0074] The modified hyaluronic acid, the initiator mixture and the modified mussel adhesion protein were respectively encapsulated in the three channels of a simple three-component glue gun, the outlet of the simple glue gun was cut, and the three channels were squeezed manually according to the mark. The component mixture is applied to the defect site, wherein the molar ratio of modified hyaluronic acid: modified m...

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Abstract

The invention discloses a barrier material, a barrier film and a preparation method and application thereof. The barrier material comprises modified hyaluronic acid, modified mussel adhesion protein and a photoinitiator. The modified hyaluronic acid includes hyaluronic acid and the first photocrosslinking agent grafted on the hyaluronic acid, and the modified mussel adhesion protein includes mussel adhesion protein and the second photocrosslinker grafted on the mussel adhesion protein. joint agent. Under the conditions of ultraviolet light irradiation and photoinitiator, the first photocrosslinking agent can react with the second photocrosslinking agent to crosslink and solidify the modified hyaluronic acid and the modified mussel adhesion protein to form a barrier film . The barrier film formed by the above-mentioned barrier material has both sufficient mechanical strength and absorbable performance, and can be applied to oral cavity materials or medical device collars.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a barrier material, a barrier film and a preparation method and application thereof. Background technique [0002] my country's oral material market is huge. According to statistics from relevant departments, the market size of the dental department is between 70 billion and 100 billion yuan, and has maintained a growth rate of more than 20% in recent years. As the main treatment for periodontal problems, oral guided tissue regeneration has the ability to promote the regeneration of alveolar bone and periodontal ligament and is widely used in the treatment of periodontal diseases. The principle is to use a barrier film formed by a barrier material to Selectively separate different periodontal tissues, prevent gingival epithelium and gingival connective tissue from growing to the root surface, thereby protecting and promoting the regeneration and repair of bone tissue. [0003] B...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14
CPCA61L31/041A61L31/14A61L31/148C08L5/08C08L89/00
Inventor 李丽花朱光林朱勇军谭荣伟佘振定
Owner SHENZHEN LANDO BIOMATERIALS
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