Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Oral composition for dissolving calcium oxalate calculus

The technology of a composition and calcium oxalate is applied in the direction of drug combinations, plant raw materials, medical preparations of non-active ingredients, etc. It can solve the problems of long taking time, difficulty in controlling the particle size of crushed stones, and many variable factors. Increase the effective concentration, improve the experience of taking, and broaden the effect of application prospects

Inactive Publication Date: 2018-11-23
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical treatment has a certain degree of risk of organ damage, and stones are very likely to recur, so repeated operations are not realistic
The structure of the kidney is very delicate and delicate. Extracorporeal shock wave lithotripsy will cause great damage to the kidney and may damage the structure of the kidney itself. This method cannot fundamentally eliminate stones, and because the process of lithotripsy is difficult to control and there are many variable factors, The particle size of crushed stones is very difficult to control. Excessively large stones may cause tearing of parts such as the urethra during the discharge process, causing unnecessary pain to the operator
Existing medicines for treating kidney stones include psilocybin and stone-dispelling liquid, etc., but they have no obvious effect, or they are taken for a very long time
In addition, for some traditional Chinese medicine Paishi granules, there is no evidence-based medical evidence to prove the ingredients and pharmacological action mechanism of the drug in its formula, and its potential side effects are not clear
On the other hand, the complications caused by these rough treatment methods require a period of recuperation, or long-term adherence to treatment cooperation, and cannot adapt to the current fast-paced social life.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oral composition for dissolving calcium oxalate calculus
  • Oral composition for dissolving calcium oxalate calculus
  • Oral composition for dissolving calcium oxalate calculus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This embodiment 1 provides a composition A for dissolving calcium oxalate stones orally. The composition A contains Garcinia cambogia extract microcapsules of Garcinia cambogia extract, and the Garcinia cambogia extract microcapsules contain vine The yellow fruit extract is converted into mass percentage and accounts for 1% of the composition A. The garcinia cambogia extract contains a certain amount of hydroxycitric acid, and the hydroxycitric acid can mildly react with calcium oxalate crystals in vivo, and the calcium oxalate crystals after the reaction become significantly smaller, and no re-deposition occurs. The calcium oxalate crystals refer to calcium oxalate stones. In other possible embodiments, the garcinia cambogia extract in the garcinia cambogia extract microcapsules accounts for 0.1%-10% of the composition A. Further preferably, the garcinia cambogia extract in the garcinia cambogia extract microcapsules accounts for 0.1%, 0.5%, 10% of the composition A. ...

Embodiment 2

[0042] This embodiment provides a composition B for orally dissolving calcium oxalate stones, the composition B contains hydroxycitric acid microcapsules. The hydroxycitric acid microcapsules contain 0.5% of hydroxycitric acid in the composition B by mass. In other possible embodiments, the hydroxycitric acid in the hydroxycitric acid microcapsules accounts for 0.1%-10% of the composition B. Further preferably, the hydroxycitric acid in the hydroxycitric acid microcapsules accounts for 0.1%, 0.3%, 0.6%, 1%, 10% of the composition B. Hydroxycitric acid can react with calcium oxalate crystals in the body, causing the size of calcium oxalate crystals to become smaller until they disappear. The product formed by the reaction of calcium oxalate crystals and hydroxycitric acid is water-soluble. Due to the existence of the hydroxyl group, the hydroxycitric acid has changed the spatial configuration, electron arrangement and other factors of the hydroxycitric acid, and the carboxylic...

Embodiment 3

[0049] This embodiment provides a composition C for orally dissolving calcium oxalate stones, the composition C contains hydroxycitric acid derivative microcapsules containing hydroxycitric acid derivatives, and the hydroxycitric acid derivative microcapsules contain hydroxycitric acid The acid derivative accounts for 1% of the composition C in terms of mass percentage. In other possible embodiments, the hydroxycitric acid derivatives in the hydroxycitric acid derivative microcapsules account for 0.1%-10% of the composition C. Further preferably, the hydroxycitric acid derivatives in the hydroxycitric acid derivative microcapsules account for 0.1%, 0.3%, 0.6%, 1%, 10% of the composition C.

[0050] Specifically, in this embodiment, the hydroxycitric acid derivative microcapsules are made of gelatin, and the hydroxycitric acid derivative microcapsules are spherical bodies coated with the garcinia cambogia extract. The composition C contains a plurality of hydroxycitric acid de...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides an oral composition for dissolving calcium oxalate calculus. The composition contains 0.1-10% of garcinia cambogia extract microcapsules or 0.1-10% of hydroxycitric acid or hydroxycitric acid derivative microcapsules. The composition contains garcinia cambogia extract microcapsules, hydroxycitric acid or hydroxycitric acid derivative microcapsules, so that calculus formed bycalcium oxalate crystals can be effectively dissolved; the materials of the garcinia cambogia extract microcapsules, hydroxycitric acid or hydroxycitric acid derivative microcapsules adopt organic polymer materials, which have certain dissolvability and are capable of conveniently controlling disintegration and dissolution time of the composition and protecting effective components in the composition to reach efficient absorption parts. The composition adopts natural extracts, is free of toxic and side effects on human body and excellent in calculus dissolving effect, can be orally taken by broad crowds, is free of strict restrictions on the crowds, and has broad application prospects.

Description

technical field [0001] The present invention mainly relates to the field of oral medicaments, in particular to a composition for dissolving calcium oxalate stones which can be absorbed orally and used for dissolving stones formed by calcium oxalate crystals. Background technique [0002] The treatment of kidney stones mainly includes three main means of surgery, extracorporeal impact lithotripsy and drug therapy. Surgical treatment has a certain degree of risk of organ damage, and stones are very likely to recur, so repeated operations are not realistic. The structure of the kidney is very delicate and delicate. Extracorporeal shock wave lithotripsy will cause great damage to the kidney and may damage the structure of the kidney itself. This method cannot fundamentally eliminate stones, and because the process of lithotripsy is difficult to control and there are many variable factors, The particle size of crushed stones is very difficult to control. Excessively large stones...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/38A61K31/194A61K9/50A61K47/38A61P13/04A61P13/12
CPCA61K9/5042A61K31/194A61K36/38A61P13/04A61P13/12A61K2300/00
Inventor 张福建侯凡凡樊秋霞
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products