Stem cell medicine for treating gonarthritis and using autologous adipose-derived stem cells for preparation

An adipose stem cell and knee arthritis technology, applied in the field of stem cell drugs, can solve the problems of unstable efficacy of knee joint stem cell drugs, inability to effectively prevent disease progression, and inability to achieve therapeutic effects, achieving rapid and effective therapeutic effects and significant curative effects. , improve the effect of the process of inducing differentiation

Pending Publication Date: 2018-11-30
广州杜德生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Conventional treatment is based on NSAIDs drugs, lubricants and steroid hormone intra-articular injections, and chondroprotective agents, but these treatments have limited efficacy and cannot effectively prevent the progression of the disease. With the development of stem cell research With continuous development and popularization, more and more researchers have extended stem cell technology to the treatment of osteoarthritis, and e

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]A kind of stem cell drug for treating knee arthritis prepared by using autologous fat stem cells, the autologous fat stem cell drug includes: 10% fat stem cells, 7% magnetic nano microspheres, 8% human serum albumin stock solution, 5% rhodiola Glycosides, 0.7% Jiaogulan Extract, 0.9% Vitamin E, 2% Flavonol Glycosides, 3% Prednisone, 1.7% Eucommia Extract, 2.3% Atractylodes Extract, 0.6% Rehmannia Root Extract, 2.1% Pittosporum Bark Extract substance, 1.1% Radix japonicus extract, 2.7% mixed scaffold, 0.6% zinc gluconate, 0.3% heparin calcium, 0.7% emulsifier, 0.7% stabilizer, 0.2% pH regulator, 0.6% antioxidant, the balance is saline. Salidroside can scavenge free radicals and promote cell growth; Gynostemma pentaphyllum extract has anti-cancer and cell cancer prevention effects; vitamin E has good antioxidant effects; flavonol glycosides can eliminate free radicals produced by cells ; Prednisone has anti-inflammatory and antibacterial pain, can inhibit cell tissue prol...

Embodiment 2

[0033] A kind of stem cell drug for treating knee arthritis prepared by using autologous fat stem cells, the autologous fat stem cell drug includes: 16% fat stem cells, 9.7% magnetic nano microspheres, 9% human serum albumin stock solution, 6% Rhodiola rosea Glycosides, 1.1% Jiaogulan Extract, 1.4% Vitamin E, 5% Flavonol Glycosides, 4% Prednisone, 2.3% Eucommia Extract, 3.7% Atractylodes Extract, 0.9% Rehmannia Root Extract, 2.9% Pittosporum Bark Extract substance, 1.4% Bordeonus extract, 3.7% mixed scaffold, 2.1% zinc gluconate, 0.4% heparin calcium, 1.3% emulsifier, 1.1% stabilizer, 0.4% pH regulator, 1.3% antioxidant, the balance is saline. Salidroside can scavenge free radicals and promote cell growth; Gynostemma pentaphyllum extract has anti-cancer and cell cancer prevention effects; vitamin E has good antioxidant effects; flavonol glycosides can eliminate free radicals produced by cells ; Prednisone has anti-inflammatory and antibacterial pain, can inhibit cell tissue p...

Embodiment 3

[0044] A stem cell drug for treating knee arthritis prepared by using autologous fat stem cells, the autologous fat stem cell drug includes: 18% fat stem cells, 11% magnetic nano microspheres, 10% human serum albumin stock solution, 7% rhodiola rosea Glycosides, 1.2% Jiaogulan Extract, 1.8% Vitamin E, 7% Flavonol Glycosides, 5% Prednisone, 3.4% Eucommia Extract, 4.4% Atractylodes Extract, 1.3% Rehmannia Root Extract, 3.9% Pittosporum Bark Extract substance, 1.9% Bordeonus extract, 4.9% mixed scaffold, 2.5% zinc gluconate, 0.5% heparin calcium, 1.5% emulsifier, 1.5% stabilizer, 0.6% pH regulator, 2% antioxidant, the balance is saline. Salidroside can scavenge free radicals and promote cell growth; Gynostemma pentaphyllum extract has anti-cancer and cell cancer prevention effects; vitamin E has good antioxidant effects; flavonol glycosides can eliminate free radicals produced by cells ; Prednisone has anti-inflammatory and antibacterial pain, can inhibit cell tissue proliferati...

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PUM

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Abstract

The invention discloses a stem cell medicine for treating gonarthritis and using autologous adipose-derived stem cells for preparation. The autologous adipose-derived stem cells are used for being induced and differentiated into chondrocytes, and the chondrocytes is combined with magnetic nano microspheres, salidroside, gynostemma pentaphyllum extract, prednisone, eucommia bark extract, atractylodes lancea extract, rehmannia glutinosa libosch root extract, erythrina indica lam extract, rabdosia rubescens extract, mixed stents and the like in a certain proportion to form the autologous adipose-derived stem cell medicine, and then the autologous adipose-derived stem cell medicine is injected into a gonarthrosis focus in the form of injection. In short, the autologous adipose-derived stem cell medicien has a good drug effect and a high curative effect, and can effectively repair articular cartilage and restore articular structures and functions.

Description

technical field [0001] The invention relates to the technical field of biotechnology, in particular to a stem cell medicine for treating knee arthritis prepared by using autologous fat stem cells. Background technique [0002] According to research and research, there are more than 400 million bone and joint patients in the world. In Asia, one out of every six people suffers from osteoarthritis at a certain stage. Generally speaking, osteoarthritis Arthropathy often occurs in middle-aged and elderly people, and it is more caused by senile degeneration, and the number of women is often more than that of men. In my country, there are more than 100 million patients with osteoarthritis, accounting for nearly 10% of the total population of our country, and the most common type of osteoarthritis is knee arthritis. According to relevant data, knee arthritis causes disability The rate of knee arthritis is the second in the world, and the incidence rate will increase with age. It can...

Claims

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Application Information

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IPC IPC(8): A61K38/38A61P19/02A61P29/00A61K36/804C12N5/0775C12N5/077A61K35/28A61K31/727A61K31/7048A61K31/7032A61K31/573A61K31/355A61K31/315
CPCA61K35/28A61K31/355A61K31/573A61K31/7032A61K31/7048A61K31/727A61K33/30A61K36/284A61K36/424A61K36/46A61K36/48A61K36/53A61K36/804A61K38/385A61P19/02A61P29/00C12N5/0655C12N5/0667C12N2500/30C12N2501/15C12N2501/38C12N2501/39C12N2501/999A61K2300/00
Inventor 夏凡张洁
Owner 广州杜德生物科技有限公司
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