Aluminum and chromium ion multi-channel response probe and synthesis method and application thereof

A chromium ion, multi-channel technology, applied in chemical instruments and methods, analysis by chemical reaction of materials, material analysis by observing the impact on chemical indicators, etc., can solve problems such as less research, and achieve synthesis methods. Simple, improved detection efficiency, and the effect of broad application prospects

Active Publication Date: 2018-11-30
INNER MONGOLIA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few studies on photoelectric dual-response aluminum and chromium ion probes.

Method used

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  • Aluminum and chromium ion multi-channel response probe and synthesis method and application thereof
  • Aluminum and chromium ion multi-channel response probe and synthesis method and application thereof
  • Aluminum and chromium ion multi-channel response probe and synthesis method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Synthesis of 2-ferrocenyl-4,5-bis(2-thienyl)imidazole

[0054] Under argon protection, ferrocene formaldehyde (100mg, 0.47mmol), 2,2'-di(2-thienyl)ethylenedione (109mg, 0.49mmol), ammonium acetate ( 725mg, 9.4mmol), 1mL glacial acetic acid and 10mL 1,4 dioxane solvent. The reaction solution was heated to reflux, and the reaction progress was monitored by thin-layer chromatography. After the reaction was complete, the reaction mixture was neutralized to pH>7 with saturated sodium carbonate solution. Extracted with dichloromethane, the extract phase was washed with water, dried, filtered, and the solvent was removed under reduced pressure. The crude product was separated by column chromatography (dichloromethane / methanol=98:2, V / V) to obtain 35 mg of yellow crystals with a yield of 49% and a melting point of 161-163°C. 1 H NMR (500MHz, (CD 3 ) 2 SO, TMS): δ12.40(s, 1H), 7.67(s, 1H), 7.39(s, 2H), 7.19-7.15(d, 2H), 7.00(s, 1H), 4.92(t, 2H) , 4.37(t, 2H), 4.41(s, 5H); ...

Embodiment 2

[0056] Synthesis of 2-ferrocenyl-4,5-bis(2-furyl)imidazole

[0057] Under argon protection, ferrocene formaldehyde (100mg, 0.47mmol), 2,2'-bis(2-furyl)ethylenedione (93mg, 0.49mmol), ammonium acetate ( 725mg, 9.4mmol), 1mL glacial acetic acid and 10mL 1,4 dioxane solvent. The reaction solution was heated to reflux, and the reaction progress was monitored by thin-layer chromatography. After the reaction was complete, the reaction mixture was neutralized to pH>7 with saturated sodium carbonate solution. Extracted with dichloromethane, the extract phase was washed with water, anhydrous MgSO 4 Dry, filter and remove the solvent under reduced pressure. The yellow crude product was separated by column chromatography, and gradient elution was carried out with dichloromethane, petroleum ether / dichloromethane / ethyl acetate (10:40:1, V / V / V) as the eluent to obtain 91 mg of yellow crystals , the yield was 70%, and the melting point was 236-238°C. 1 H NMR (500MHz, (CD 3 ) 2 SO, TMS...

Embodiment 3

[0059] The effect of fluorescent detection probe on each ion

[0060] Prepare 1×10 in 100mL volumetric flask -4 The embodiment 1 of mol / L and the probe molecular acetonitrile solution of embodiment 2, in 25mL volumetric flask, preparation concentration is 2.5 * 10 -3 mol / L aqueous solutions of different metal ions; use a pipette gun to take out 2mL 1×10 -4 After the mol / L probe molecule acetonitrile solution was mixed with 80 uL of the above-mentioned ion solutions, the fluorescence emission spectrum was tested in the range of 350-650 nm (excitation wavelength was 320 nm).

[0061] The result shows, the probe molecule of embodiment 1 and embodiment 2 is only to Al 3+ 、Cr 3+ Ion has fluorescence response; The probe molecule of embodiment 1 and embodiment 2 adds Al 3+ 、Cr 3+ Strong fluorescence emission peaks appear at 474nm and 480nm respectively after the ions, and the fluorescence intensity increases by 42-132 times; its selectivity is manifested in the addition of Na +...

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Abstract

The invention discloses an aluminum and chromium ion multi-channel response probe and a synthesis method and application thereof. The probe molecule is a 2-ferrocenylimidazole-4, 5-diheteroaryl derivative. The unique whole structure of the probe molecule can selectively bind to Al<3+> and Cr<3+> ions. Ferrocene is used as an electrical signal response center and imidazole and aromatic heterocycleare used as electrical signal response centers. Through change of fluorescence, electrochemistry and colorimetry, the probe responds to identify Al<3+> and Cr<3+> ions. The probe molecule integrates the advantages of the fluorescent probe and the electrochemical probe, realizes multi-channel and high selectivity detection of Al<3+> and Cr<3+> ions and has an Al<3+> detection lower limit of 2.21*10<-6>-3.06*10<-5>M and a Cr<3+> detection lower limit of 4.54*10<-5>-2.40*10<-5>M. The probe has a stable structure and has wide application prospects. The synthesis and use methods are simple.

Description

technical field [0001] The invention belongs to the field of photoelectric functional materials, and specifically relates to the design, synthesis and application of an aluminum and chromium ion multi-channel response probe. Background technique [0002] Aluminum and chromium elements are widely present in the human living environment. High concentrations of aluminum (Al 3+ ) will not only cause toxicity to aquatic animals and plants, but also cause a variety of serious diseases in the human nervous system and digestive system due to its excessive accumulation in the human body. Chromium (Cr 3+ ) is one of the essential trace elements for the human body. It has physiological functions that cannot be ignored in the metabolism of carbohydrates and lipids in the human body. Lack of or excessive intake of chromium will affect human health. Therefore, the selective identification and quantitative analysis of aluminum and chromium ions are of great significance for the effectiv...

Claims

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Application Information

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IPC IPC(8): C07F17/02C09K11/06G01N21/64G01N27/26G01N21/78
CPCC07F17/02C09K11/06C09K2211/187G01N21/6428G01N21/78G01N27/26
Inventor 王亚琦索全伶韩利民
Owner INNER MONGOLIA UNIV OF TECH
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