A kind of estradiol production process and production device

Abstract

The invention discloses an estradiol production device. The device comprises a reaction kettle, an elutriation kettle, a centrifuge, a concentrating kettle, a decolorization kettle and a drying device, wherein the drying device comprises an outer cylinder, a drying cylinder and an inner cylinder, a motor is arranged on the bottom surface of the outer cylinder, and an exhaust fan blade, a cylinder-type impeller and a vortex impeller are arranged on the rotating shaft of the motor; the exhaust fan blade is disposed between the drying cylinder and the bottom surface of the outer cylinder, the cylinder-type impeller is disposed between the drying cylinder and the inner cylinder, and the vortex impeller is arranged at the bottom of the inner cylinder; an infrared heating tube is arranged on thetop surface of the inner cylinder, an air purifying ring is arranged at the upper end of a sandwich cavity of the outer cylinder, and a material inlet is formed in the center of a top plate; a sliding rod is arranged at the edge of the material inlet, a tray is connected to the lower end of the sliding rod, and a screw rod is arranged on the side edge of the material inlet; a screw sleeve is arranged on the screw rod, a gear ring which is arranged on the screw sleeve is meshed with a drive gear, and the drive gear is connected with a drive motor; and the lower end of the screw rod is connected with the tray, and a cover plate is connected with tops of the sliding rod and the screw rod. Through the estradiol production device, the preparation time of an intermediate product during production of estradiol can be reduced, and rapid high-quality production of estradiol can be realized.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical production, in particular to an estradiol production process and a production device. Background technique [0002] Estradiol is an estrogen therapeutic that is absorbed through the skin. Supplement the deficiency of 17-β-estradiol secreted by female ovaries, and at the same time avoid the side effects caused by oral administration (breast pain, weight gain, high blood pressure, gallstones and abnormal liver function, etc.). Estrogen can prompt cells to synthesize DNA, RNA and various proteins in corresponding tissues. During the production of traditional estradiol, due to the need for multi-step chemical reactions for production, the intermediate product raw materials formed need to be dried multiple times, while the existing drying equipment generally adopts electric resistance wire heating and drying or complete vacuum pumping. Pressure dehumidification, heating and drying of electric ...

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Problems solved by technology

During the production of traditional estradiol, due to the need for multi-step chemical reactions for production, the intermediate product raw materials formed need to be dried multiple times, while the existing drying equipment generally adopts electric resistance wire heating and drying or complete vacuum pumping. Pressure dehumidification, heating and drying of electric heating resistance wires tend to have a relatively large negative impact on the intermediate product of estradiol preparation, resulting in changes in the structure of the intermediate product, which eventually lead to the instability of subsequent estradiol crystallization and the decrease in purity. Electric resistance wire heating drying equipment or vacuum negative pressure dehumidification equipment have a long drying time. Although vacuum negative pressure dehumidification can achieve rapid dehumidification by rapid decompression, rapid decompression is easy to change the shape and structure of intermediate products. Mutations are impaired, reducing the quality of subsequent estradiol production

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