Small-caliber bionic blood vessel with three-layer structure and manufacturing method thereof

A bionic blood vessel, three-layer structure technology, applied in the field of bionic blood vessels, can solve the problems of inability to meet the needs of small-diameter blood vessels, easy to form thrombus, vascular intimal hyperplasia, etc., achieve high strength, promote cell reproduction, and improve the effect of burst pressure.

Pending Publication Date: 2018-12-07
HUNAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently widely used synthetic blood vessels cannot meet the needs of small-diameter vessels
The reason is that when th

Method used

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  • Small-caliber bionic blood vessel with three-layer structure and manufacturing method thereof
  • Small-caliber bionic blood vessel with three-layer structure and manufacturing method thereof
  • Small-caliber bionic blood vessel with three-layer structure and manufacturing method thereof

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Experimental program
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Effect test

preparation example Construction

[0042] According to the three-layer structure small-caliber bionic blood vessel, a preparation method is provided, the steps include:

[0043] S1. Use silk fiber to weave a net-like inner layer structure outside the round tube;

[0044] S2. In step S1, a hollow cylindrical mold is used to pour the polyacrylamide hydrogel precursor solution to cross-link the polyacrylamide hydrogel precursor solution to obtain a silk fiber / polyacrylamide hydrogel tube double-layer structure;

[0045] S3. Prepare a polyurethane nanofiber outer layer structure outside the double-layered silk fiber / polyacrylamide hydrogel tube obtained in step S2 to obtain a three-layer structure small-diameter bionic blood vessel.

[0046] Further, in step S1, the inner layer meshed silk fiber has a ring diameter of 2-5 mm and a thickness of 100-200 μm; the polyacrylamide hydrogel tube in step S2 has a diameter of 400-600 μm; and the polyurethane nanometer in step S3 The fiber diameter is 50-150nm, and the thickness is 5...

Embodiment 1

[0057] This embodiment provides a method for preparing a small-caliber bionic blood vessel with a three-layer structure.

[0058] S1. Use 50μm diameter silk fiber to weave a 100μm thick net-like inner layer structure outside a 2mm round tube;

[0059] S2. Use acrylamide and phosphate buffer to make a 2mol / L solution, add 0.06% of acrylamide mass of methylene bisacrylamide and 0.17% of acrylamide mass of ammonium persulfate to the solution, add propylene after dissolving 0.25% of the amide mass of tetramethylethylenediamine is fully stirred to obtain a polyacrylamide hydrogel precursor.

[0060] S3. Use a hollow cylindrical mold to cast the polyacrylamide hydrogel precursor prepared in step S2 on the silk woven in step S1 and irradiate it with ultraviolet for 40 minutes to obtain a silk fiber / polyacrylamide hydrogel tube double-layer structure;

[0061] S4. The polyurethane is dissolved in dimethylformamide to prepare a polyurethane solution with a concentration of 10wt.%;

[0062] S5. ...

Embodiment 2

[0064] This embodiment provides a method for preparing a small-caliber bionic blood vessel with a three-layer structure.

[0065] S1. Use 50μm diameter silk fiber to weave a 100μm thick net-like inner layer structure outside a 2mm round tube;

[0066] S2. Use acrylamide and phosphate buffer to make a 2mol / L solution, add 0.06% of acrylamide mass of methylene bisacrylamide and 0.17% of acrylamide mass of ammonium persulfate to the solution, add propylene after dissolving 0.25% of the amide mass of tetramethylethylenediamine is fully stirred to obtain a polyacrylamide hydrogel precursor.

[0067] S3. Use a hollow cylindrical mold to cast the polyacrylamide hydrogel precursor prepared in step S2 on the silk woven in step S1, and heat it at 50°C for 40 minutes to obtain a silk fiber / polyacrylamide hydrogel tube double-layer structure ;

[0068] S4. The polyurethane is dissolved in dimethylformamide to prepare a polyurethane solution with a concentration of 10wt.%;

[0069] S5. Using the d...

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Abstract

The invention discloses a small-caliber bionic blood vessel with a three-layer structure and a manufacturing method thereof. Knitted silk fiber is adopted as an inner layer of the bionic blood vesselto simulate the structure and properties of human body blood vessel collagen, electrostatic spun polyurethane fiber serves as an outer layer to simulate the structure and properties of blood vessel elastin. In addition, polyacrylamide hydrophilic gel is also adopted as a middle layer to further improve the elasticity of the bionic blood vessel, meanwhile improve the bursting pressure of the bionicblood vessel and prevent blood permeation in the use process. The microcosmic three-layer structure of the human blood vessel can be simulated, and the special nonlinear mechanical properties of thehuman blood vessel can be also simulated. In addition, the raw materials for the bionic blood vessel have good cytocompatibility, are degradable and are suitable for blood vessel repair and regeneration in tissue engineering. Therefore, the small-caliber bionic blood vessel with the three-layer structure has a high potential practical value.

Description

Technical field [0001] The invention relates to the technical field of bionic blood vessels, and more specifically, to a three-layer structure small-caliber bionic blood vessel and a preparation method thereof. Background technique [0002] In recent years, tens of thousands of patients have been suffering from cardiovascular and cerebrovascular diseases. The purpose of tissue engineering is to provide regenerative resources for damaged tissues or organs and provide reliable treatments for various diseases. The goal of vascular tissue engineering is to prepare functional blood vessels that can be implanted in the body to replace diseased blood vessels, thereby helping the regeneration of new blood vessels. Large-diameter synthetic blood vessels such as polyethylene terephthalate (PET) from Dacron and expanded polytetrafluoroethylene (ePTFE) from Gore have been successfully used in the aorta with high-speed blood flow, such as the chest. , Abdominal aorta. However, the currentl...

Claims

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Application Information

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IPC IPC(8): A61F2/06C08F220/56C08F222/38
CPCA61F2/06C08F220/56C08F222/385
Inventor 米皓阳经鑫刘跃军童立生
Owner HUNAN UNIV OF TECH
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