Amino sugar hemostatic medical material, and preparation method and application thereof

A technology of amino sugar and amino polysaccharide, which is applied in the field of medicine and biology, can solve the problems of limited functional effect of chitosan and unsatisfactory dressing effect, etc., and achieve the effect of shortening hemostasis time, significant hemostasis effect and broad market prospect

Inactive Publication Date: 2019-01-25
青岛博益特生物材料股份有限公司
View PDF6 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These reports usually make chitosan into water-insoluble chitosan powder, chitosan film, chitosan sponge, chitosan fiber and fabric, etc., but due to the limited functional effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: the preparation of oxidized starch

[0011] Weigh 15g of starch, put it into a 500ml glass triangular flask, add 200ml of water, heat and stir to dissolve, adjust the pH value to pH5.5 with 5% (weight percentage, the same below) acetic acid aqueous solution, add the oxidant NaIO 4 3.5g, seal, and stir oxidation reaction at room temperature for 24h in the dark. After the reaction was completed, the reaction solution was put into a dialysis bag with a molecular weight cut-off of 3000 Daltons, protected from light, and dialyzed with distilled water at 4°C for 24 hours, wherein the distilled water was replaced every 6 hours. After the dialysis, the liquid in the dialysis bag was freeze-dried in a freeze dryer for 48 hours to obtain 13.5 g of oxidized starch containing dialdehyde groups, and the percentage content of dialdehyde groups was 12.5% ​​(the percentage content of dialdehyde groups refers to polysaccharide The percentage of sugar units containing dia...

Embodiment 2

[0012] Embodiment 2: the preparation of oxidized carboxymethyl cellulose

[0013] Weigh 15g of carboxymethyl cellulose powder, add it to a 1000ml glass conical flask, add 800ml of water, stir to dissolve, adjust the pH value to pH5.5 with 5% acetic acid aqueous solution, add the oxidizing agent KIO 4 8g, seal, and stir the oxidation reaction at room temperature for 60h in the dark. After the reaction is completed, add 4 times the volume of 95% ethanol aqueous solution under stirring, precipitate, and filter the precipitate with suction, wash 3 times with 95% ethanol aqueous solution, dehydrate with absolute ethanol, and dry in vacuo to obtain dialdehyde group-containing oxidized carboxyl Methylcellulose 12.1g, its dialdehyde percentage content is 62.5%.

Embodiment 3

[0014] Embodiment 3: the preparation of oxidized alginic acid

[0015] Weigh 15g of sodium alginate, add it to a 1000ml glass conical flask, add 800ml of water, stir to dissolve, adjust the pH value to pH5.0 with 1mol / L hydrochloric acid aqueous solution, add oxidant KIO 4 9g, seal, and stir the oxidation reaction at 4°C for 36h in the dark. After the reaction was completed, the reaction solution was put into a dialysis bag with a molecular weight cut-off of 3000 Daltons, protected from light, and dialyzed with distilled water at 4°C for 24 hours, wherein the distilled water was replaced every 6 hours. After the dialysis, the liquid in the dialysis bag was freeze-dried in a freeze dryer for 48 hours to obtain 13 g of oxidized sodium alginate containing dialdehyde groups, and the percentage content of dialdehyde groups was 48.5%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an amino sugar hemostatic medical material, and a preparation method and application thereof. The amino sufar hemostatic medical material is a membrane-like or sponge-like product formed by cross-linking reaction of aminoglycan and oxidized polysaccharide; the amino polysaccharide is one or more of hyaluronic acid, chondroitin sulfate, heparin, chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, sulfonated chitosan, hydroxybutyl chitosan, carboxymethyl chitosan, succinyl chitosan or other chitosan derivatives; the oxidized polysaccharide is one or several of oxidized polysaccharides containing dialdehyde groups, wherein the percentage of sugar units containing dialdehyde groups to the total sugar units of the polysaccharide molecule is 1% to 70%. The amino sugar hemostatic medical material of the invention has remarkable hemostatic effect, remarkably shortens hemostatic time of wound surface, is non-toxic, and has good biocompatibility. It can be used to prepare traumatic hemostasis and surgical hemostasis medical devices, as hemostasis dressing medical devices for development, has broad market prospects.

Description

technical field [0001] The invention relates to a hemostatic biological material, in particular to an amino sugar hemostatic medical material and its preparation method and application, belonging to the field of medical biotechnology. Background technique [0002] Clinically used medical dressings generally include hydrogel materials, film materials, sponge materials, powder materials, etc. Film materials and sponge materials often have good mechanical properties, which can cover the wound surface, block microorganisms, and provide gas exchange. An ideal hemostatic material needs to have rapid hemostasis and healing-promoting properties, and at the same time have good liquid absorption and tissue compatibility, be able to cover wounds, protect wounds, and accelerate wound healing. Multifunctional hemostatic materials have been the main research direction of hemostatic materials at home and abroad. [0003] Clinical hemostatic materials mainly include hemostatic material pr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L24/00A61L24/08
CPCA61L24/0036A61L24/043A61L2400/04C08L1/04C08L3/10C08L5/08C08L5/10C08L5/00
Inventor 刘万顺宋福来冯伊琳
Owner 青岛博益特生物材料股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap