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A short lipopeptide with specific anti-Propionibacterium acnes and anti-inflammatory effects

A technology of Propionibacterium acnes and lipopeptide, applied in the biological field, can solve the problems of secondary infection and poor specificity, and achieve the effect of low toxicity, low cost and high antibacterial effect

Active Publication Date: 2021-10-26
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Secondly, most of these peptides have broad-spectrum antibacterial activity, and their specificity is poor. When used, they may also kill beneficial bacteria in the human body, resulting in secondary infection

Method used

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  • A short lipopeptide with specific anti-Propionibacterium acnes and anti-inflammatory effects
  • A short lipopeptide with specific anti-Propionibacterium acnes and anti-inflammatory effects
  • A short lipopeptide with specific anti-Propionibacterium acnes and anti-inflammatory effects

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Experimental program
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Embodiment 1

[0040] 1.1 Experimental method

[0041] 1.1.1 Polypeptide synthesis

[0042] Peptides were synthesized by solid phase synthesis using amide MHBA resin and standard 9-fluorenylmethoxycarbonyl (Fmoc) amino acids. Peptide extension reaction conditions are as follows: standard HBTU / HOBt used as coupling agent, N-dimethylformamide as solvent, 10-fold excess of diisopropylethylamine, 3-fold excess of Fmoc protecting group amino acid or 5-fold excess of free fatty acids. The peptide was cleaved from the resin using a reagent consisting of 87.5% trifluoroacetic acid, 2.5% ethanedithiol, 5% thioanisole, and 5% deionized water, and reacted for 3 hours at room temperature, after which the peptide was exposed to methyl-tert-butyl Precipitate in ether-petroleum ether (volume ratio 1:1). The molecular weight of the peptide was confirmed by electrospray ionization mass spectrometry (ESI-MS, Waters, USA). The purity of the peptide was analyzed on a C18 column (250 × 4.6 mm; Shimadzu, Kyot...

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Abstract

The invention discloses a short lipopeptide with specific anti-Propionibacterium acnes action and anti-inflammatory action, and belongs to the field of biotechnology. The short lipopeptide is composed of C6-C20 fatty acids and an amino acid sequence with the general formula KWKW. The short lipopeptide of the present invention can specifically inhibit the growth of Propionibacterium acnes and reduce the inflammatory response of tissues around hair follicles. In vivo and in vitro experiments show that the short lipopeptide of the present invention has high antibacterial and anti-inflammatory activities and low toxicity. In addition, the short lipopeptide has a different mechanism of action from traditional antibiotics, and the short lipopeptide is extremely difficult to produce drug resistance, especially effective for strains that have already developed resistance to existing antibiotics, so it can achieve the fundamentals of preventing and treating acne and improving the quality of life Purpose. The short lipopeptide of the present invention is a compound or complex containing lipids and amino acids, which can be added to various toiletries or cosmetics, is safe and environmentally friendly, and has broad market prospects.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a short lipopeptide with specific anti-Propionibacterium acnes action and anti-inflammatory action. Background technique [0002] Acne is a common chronic inflammatory skin disease of the pilosebaceous glands in teenagers. It occurs mostly in the head, face, neck and other parts rich in sebaceous glands. In severe cases, skin cancer may also form; (2) It may lead to the formation of acne spots, acne pits, acne scars, etc., affecting young people's career choice, spouse selection, and communication, causing adolescent depression, withdrawn personality, low self-esteem, and affecting the patient's mental health . One of the main pathogenic factors causing acne is Propionibacterium acnes, and moderate to severe inflammatory lesions are currently treated with systemic or topical antibiotics. However, traditional antibiotics are easy to make bacteria resistant, leading to a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K5/09A61K38/07A61P17/10A61K8/64A61Q19/10A61Q19/00
CPCA61K8/64A61K38/00A61Q19/00A61Q19/10A61P17/10C07K5/0815C07K19/00
Inventor 何坚杨光王静瑜
Owner SOUTHERN MEDICAL UNIVERSITY
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