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Method for preparing anti-inflammatory, antibacterial and bacteriostatic components for toothpaste by medicinal extract-microcapsules

A technology of medicinal materials and extracts, applied in the directions of drug combinations, pharmaceutical formulations, topical antibacterial agents, etc., to achieve the effects of alleviating gingival inflammation, excellent stain removal effect, and good bacteriostatic ability

Inactive Publication Date: 2019-02-15
安徽万春日化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] There are no related reports about applying it to toothpaste products and studying its content stability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for preparing toothpaste anti-inflammatory, antibacterial and antibacterial components with medicinal material extract-microcapsules, characterized in that it comprises the following steps:

[0035] (1) Extraction, purification and decolorization process of tea saponin:

[0036] Add the extraction solvent ethanol aqueous solution to 30 parts of the pretreated tea seed meal powder at a solid-to-liquid ratio of 1:8, extract at 70-75°C for 2 hours, ultrasonically treat for 15 minutes, filter while it is hot, and add 25 parts of shellfish to the filtrate Polysaccharide acetic acid solution, heat and reflux at 70-75°C for 50 minutes, let stand at room temperature for 2 hours, centrifuge for 15 minutes to filter the supernatant, add 20 parts of hydrogen peroxide to the supernatant, heat to 60-65°C and reflux for 1 hour, decompress Concentrate, freeze-dry to powder, add solvent acetone according to the solid-to-liquid ratio of 1:30, Soxhlet extraction for 4 hours, and...

Embodiment 2

[0048] A method for preparing toothpaste anti-inflammatory, antibacterial and bacteriostatic components with herbal extract-microcapsules, characterized in that it comprises the following steps:

[0049] (1) Extraction, purification and decolorization process of tea saponin:

[0050] Add the extraction solvent ethanol aqueous solution to 40 parts of pretreated tea seed meal powder according to the solid-to-liquid ratio of 1:9, extract at 70-75°C for 3 hours, ultrasonically treat for 20 minutes, filter while it is hot, and add 30 parts of shellfish to the filtrate Polysaccharide acetic acid solution, heated and refluxed at 70-75°C for 60 minutes, left to stand at room temperature for 3 hours, centrifuged for 20 minutes to filter the supernatant, added 25 parts of hydrogen peroxide to the supernatant, heated to 60-65°C and refluxed for 2 hours, decompressed Concentrate, freeze-dry to powder, add solvent acetone according to the solid-to-liquid ratio of 1:30, Soxhlet extraction f...

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PUM

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Abstract

The invention discloses a method for preparing anti-inflammatory, antibacterial and bacteriostatic components for toothpaste by medicinal extract-microcapsules. The method comprises steps as follows:a gelatin solution and a sodium alginate solution are mixed, paeonol crystals and magnolol crystals are added, high-speed shearing dispersion is performed, pH is slowly regulated by an aqueous aceticacid solution during electric stirring, a mixed solution is pressurized by an air compression pump and sprayed to a curing agent solution, an anti-sticking agent is added, filter pressing is performedby a positive-pressure filter, and paeonol-magnolol crystal microcapsules are obtained by reduced-pressure drying; the microcapsules are mixed uniformly with purified and decolored tea saponin, fructus chebulae extract and hairy artemisia extract, and the anti-inflammatory, antibacterial and bacteriostatic components for the toothpaste are prepared. Gelatin and sodium alginate are taken as wall materials, the paeonol crystals and the magnolol crystals are taken as capsule-cores, the paeonol and the magnolol crystals are micro-encapsulated with a complex coacervation method, the wall materialsprepared from gelatin and sodium alginate by complex coacervation can well protect capsule-core substances from being oxidized, and the microcapsules prepared from gelatin and sodium alginate as thewall materials with the complex coacervation method have good oxidation resistance.

Description

technical field [0001] The invention belongs to the technical field of toothpaste, and in particular relates to a method for preparing an anti-inflammatory, antibacterial, and antibacterial component for toothpaste from medicinal material extract-microcapsules. Background technique [0002] my country is a big tea-producing country, rich in Camellia oleifera resources, featuring high output, wide distribution, and diverse varieties. [0003] In daily production, tea seed oil is usually extracted from tea seeds, but due to cost, technology and other reasons, after production [0004] The remaining tea seed meal is directly discarded or burned as agricultural waste, causing adverse effects on the environment. In fact, [0005] The tea seed meal left after extracting oil by pressing not only contains a little tea oil and water, but also contains components with practical value including tea protein, tea polysaccharide, tea saponin, tannin, alkaloid, etc., among which the most...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/34A61K8/35A61K8/65A61K8/73A61K36/82A61P1/02A61P7/04A61P31/02A61Q11/00A61K31/05A61K31/12A61K31/704A61K36/185A61K36/282
CPCA61K8/9789A61K8/347A61K8/35A61K8/65A61K8/733A61K31/05A61K31/12A61K31/704A61K36/185A61K36/282A61K36/82A61K2800/56A61P1/02A61P7/04A61P31/02A61Q11/00A61K2300/00
Inventor 刘宁
Owner 安徽万春日化有限公司