Preparation method of agarose acetate nano fiber membrane
A technology of agarose acetate and nanofiber membranes, which can be used in pharmaceutical formulations, medical science, and prostheses, and can solve problems such as single bone repair materials, and achieve excellent surface morphology, improved hydrophilicity and mechanical properties, and wettability Good performance and mechanical stability
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[0034] A preparation method of agarose acetate nanofiber membrane, comprising the preparation of agarose acetate, the preparation of electrospinning solution and the preparation of nanofiber membrane;
[0035] The preparation of described agarose acetate comprises:
[0036] Step 1, adding agarose to glacial acetic acid and magnetically stirring for 1-3 hours, then adding acetic anhydride and sulfuric acid to react for 0.5-5 hours to obtain agarose acetate suspension;
[0037] Step 2, the agarose acetate suspension is washed with distilled water several times until the filtrate after suction filtration is in the center, then the agarose acetate obtained by filtration is frozen and dried;
[0038] The preparation of described electrospinning liquid comprises:
[0039] Step 3, adding the dried agarose acetate in step 2 to the organic solvent, and stirring at room temperature for 5-10 hours to obtain a homogeneous agarose acetate solution;
[0040] Step 4: Add the β-tricalcium p...
Embodiment 1
[0052] A kind of preparation method of agarose acetate nanofiber film, comprises the steps:
[0053] (1) Preparation of agarose acetate:
[0054] Weigh 3g of dried agarose (Mw=3 million), put it into a flask containing 30mL of glacial acetic acid, stir the agarose magnetically to swell for 2h, then add 24mL of acetic anhydride and 0.4mL of sulfuric acid, and react at 50°C 2.0h. After the reaction, wash with distilled water several times, filter with suction until the filtrate is neutral, and finally freeze the agarose acetate and dry to obtain the product.
[0055] (2) Preparation of electrospinning solution:
[0056] In order to prepare the polymer solution, first dissolve 6 g of agarose acetate in a mixed organic solvent of 100 mL of dimethylacetamide and acetone (V:V=1:1), stir at room temperature for 6 h to obtain agarose acetate The concentration is 6% (g / mL) homogeneous solution. Then, 3 g of β-tricalcium phosphate powder was added to the above solution and continued...
Embodiment 2
[0061] A kind of preparation method of agarose acetate nanofiber film, comprises the steps:
[0062] (1) Preparation of agarose acetate:
[0063] Weigh 6g of dried agarose (Mw=2 million), put it into a flask filled with 40mL of glacial acetic acid, stir the agarose magnetically to swell for 3h, then add 35mL of acetic anhydride and 0.5mL of sulfuric acid, and react at 50°C 2.0h. After the reaction, wash with distilled water several times, filter with suction until the filtrate is neutral, and finally freeze the agarose acetate and dry to obtain the product.
[0064] (2) Preparation of electrospinning solution:
[0065] In order to prepare the polymer solution, first dissolve 8 g of agarose acetate in a mixed organic solvent of 100 mL of dimethylacetamide and acetone (V:V=1:1), stir at room temperature for 10 h to obtain agarose acetate The concentration is 8% (g / mL) homogeneous solution. Then, 2.4g of β-tricalcium phosphate powder was added to the above solution and contin...
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