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Preparation method of magnesium matrix composite bone implant and product thereof

A technology for composite materials and bone implants, applied in prostheses, pharmaceutical formulations, additive processing, etc., can solve the problems of increased workload and refined structure, and achieve enhanced corrosion resistance, mild process, and avoid splash and gas effect of the phenomenon

Inactive Publication Date: 2019-02-22
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no particularly effective means of support has been developed so far, mainly relying on manual grinding, which increases the tedious workload on the one hand, and poses a great challenge to the fine structure protection of bone implants on the other hand.

Method used

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Examples

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Effect test

preparation example Construction

[0025] A method for preparing a magnesium-based composite material bone implant, the method comprising the following steps:

[0026] (1) The patient's part is scanned by medical imaging means CT / MRI, and the Dicom medical tomographic image is read in by the 3D reconstruction software Mimics for processing and editing, and an STL format file that highly matches the 3D model of the patient's bone tissue is generated;

[0027] (2) Weigh a specific amount of medical spherical magnesium alloy powder and nano-sized hydroxyapatite (HA) powder and place them in a ball mill. Under the protection of high-purity argon, set the speed of the ball mill to 100-200rad / min. ~10 hours to obtain a composite material in which hydroxyapatite particles are evenly distributed on the surface of the spherical magnesium alloy;

[0028] (3) Fill the powder feeding chamber with the composite powder, and import the STL file into the 3DP printer;

[0029] (4) The program controls the forming table to drop...

Embodiment 1

[0042] A method for preparing a magnesium-based composite material bone implant provided by the first embodiment of the present invention includes the following steps:

[0043] (1) The patient's part is scanned by medical imaging means CT / MRI, and the Dicom medical tomographic image is read in by the 3D reconstruction software Mimics for processing and editing, and an STL format file that highly matches the 3D model of the patient's bone tissue is generated;

[0044] (2) Weigh 92wt% AZ91 powder and 8wt% nano-sized hydroxyapatite (HA) powder and place them in a ball mill, under the protection of high-purity argon, set the ball mill rotation speed to 200rad / min, and ball mill for 10 hours to obtain A composite material in which hydroxyapatite particles are uniformly distributed on the surface of a spherical magnesium alloy;

[0045] (3) Fill the powder feeding chamber with the composite powder, and import the STL file into the 3DP printer;

[0046] (4) The program controls the ...

Embodiment 2

[0051] A method for preparing a magnesium-based composite material bone implant provided by the second embodiment of the present invention includes the following steps:

[0052] (1) The patient's part is scanned by medical imaging means CT / MRI, and the Dicom medical tomographic image is read in by the 3D reconstruction software Mimics for processing and editing, and an STL format file that highly matches the 3D model of the patient's bone tissue is generated;

[0053] (2) Weigh 95wt% AZ91 powder and 5wt% nano-sized hydroxyapatite (HA) powder and place them in a ball mill, under the protection of high-purity argon, set the ball mill rotation speed to 150rad / min, and ball mill for 6 hours to obtain A composite material in which hydroxyapatite particles are uniformly distributed on the surface of a spherical magnesium alloy;

[0054] (3) Fill the powder feeding chamber with the composite powder, and import the STL file into the 3DP printer;

[0055] (4) The program controls the ...

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Abstract

The invention belongs to the field of bio-implant materials and discloses a preparation method of a magnesium matrix composite bone implant and a product thereof. The preparation method of the magnesium matrix composite bone implant comprises (a) structuring a three-dimensional structure of the bone implant, selecting spherical magnesium alloy powder and nano-hydroxyapatite (HA) as raw materials,ball-milling the two materials to prepare uniformly-mixed magnesium matrix composite powder; (b) performing shaping treatment on the magnesium matrix composite powder according to the three-dimensional structure through a three-dimensional jet printing process to obtain a green body of the bone implant; (c) vacuum-sintering the green body to evaporate adhesives inside the green body to obtain therequired customized bone implant with a porous structure. The preparation method of the magnesium matrix composite bone implant saves additional support and is low in requirements on printing environment, capable of avoiding burning loss of powder elements, few in impurities, high in efficiency and low in cost.

Description

technical field [0001] The invention belongs to the field of biological implant materials, and more specifically relates to a preparation method of a magnesium-based composite material bone implant and a product thereof. Background technique [0002] In recent years, magnesium alloys have great applications in the field of medical implants due to their excellent mechanical compatibility and biocompatibility with human bones, especially in effectively reducing the "stress shielding" effect and being naturally degradable in the human body. It has become a research hotspot in the new generation of orthopedic implants. [0003] At present, implants for clinical application are mainly manufactured in a standardized manner using traditional machining, mold forming and other methods. However, human bones have individualized shape characteristics, resulting in a situation where standardized implants do not match personalized bones. affect the therapeutic effect. In addition, the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/04A61L27/50A61L27/56A61L27/58B33Y10/00B33Y70/00
CPCA61L27/047A61L27/12A61L27/50A61L27/56A61L27/58A61L2400/12A61L2430/02B33Y10/00B33Y70/00
Inventor 魏青松周华田健毛贻伟傅华刘洁文世峰史玉升
Owner HUAZHONG UNIV OF SCI & TECH
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