Photodynamic super-hydrophobic anti-infection coating and preparation method thereof

Abstract

The invention provides a preparation method of a photodynamic super-hydrophobic anti-infection coating. The preparation method of the photodynamic super-hydrophobic anti-infection coating comprises the following steps: a) depositing silicon dioxide on the surface of a substrate material in situ to obtain a surface-treated substrate material; b) chemically bonding a photosensitizer to the surface of the surface-treated substrate material obtained in step a) to obtain a material of which the surface is bonded with the photosensitizer; and c) carrying out fluorination treatment on the material ofwhich the surface is bonded with the photosensitizer obtained in step b) to obtain the photodynamic super-hydrophobic anti-infection coating. The photodynamic super-hydrophobic anti-infection coatingis prepared by specific processes and conditions; the photodynamic super-hydrophobic anti-infection coating has super-hydrophobicity, is suitable for a dry environment and a wet environment, and is wide in application environment range; and moreover, the anti-adhesion efficiency and the sterilizing efficiency are high, the antibacterial durability is good, a broad-spectrum long-acting repeated anti-fouling and antibacterial function can be fulfilled, and bacteria cannot be induced to have drug fastness by a photodynamic sterilizing mode.

Description

technical field [0001] The invention relates to the technical field of anti-infection coatings, in particular to a photodynamic super-hydrophobic anti-infection coating and a preparation method thereof. Background technique [0002] For a long time, infections caused by pathogenic bacteria have seriously threatened human health and social development. According to the survey of disease classification from 1995 to 2007, infectious diseases in China accounted for 49% of the total incidence of all diseases, among which the incidence of bacterial infection was as high as 18%-21%, and due to the excessive use of antibiotics in treatment, it led to deaths every year The number is as high as 80,000 people. In order to effectively control the spread of bacteria and cut off the transmission route, medical institutions often use various disinfection and sterilization methods, including the extensive use of antibacterial disinfectants or drugs. However, due to the abuse of these reag...

AI Technical Summary

Problems solved by technology

Active bactericidal surfaces usually use physical or chemical methods to fix antibacterial agents, such as quaternary ammonium salts, antibiotics, chitosan, silver ions, etc., to the surface of the substrate material, and perform the bactericidal function through release or contact. The short-term bactericidal performance is excellent, but the bactericidal process relies too much on bactericides, which will accelerate the induction of bacterial resistance

Passive anti-adhesion surfaces mainly reduce or inhibit the chance of bacterial infection by weakening the interaction between bacteria and the surface or interfering with biofilm formation, such as by constructing a hydrophilic coating (polyethylene glycol or amphoteric inner salts and However, this type of surface can only slow down but cannot prevent the occurrence of bacterial infection for a long time

In recent years, the construction strategy of anti-bacterial adhesion-bactericidal synergistic functional surface has been continuously developed, which can reduce the number of bacterial adhesion and effectively kill bacteria, which can greatly reduce the risk of infection; however, the current anti-bacterial synergistic antibacterial surfaces mainly use The hydrophilic type is the main type, and only in a humid environment can it produce a better synergistic antibacterial effect. Under dry conditions, it is easy to cause bacterial adhesion or accumulation of dead bacterial debris, which in turn induces subsequent bacterial infection, resulting in poor persistent antibacterial effect

In addition, superhydrophobic coatings have also been researched and applied in the field of anti-infection coating technology, but their functions are generally single.

Although some studies have added antibacterial components to the hydrophobic coating to achieve the integrated integration of hydrophobic and antibacterial functions, the antibacterial active components on the surface are easy to dissolve, resulting in a decrease in the antibacterial durability of the coating.

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