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Compound occrycetin, dried alum and borneol effervescent tablet and preparation method thereof

A technology of oxytetracycline hydrochloride and effervescent tablets, applied in the field of effervescent tablets, can solve the problems of poor solubility, small contact area between uterine mucosa and vagina, unsatisfactory treatment effect, etc., and achieves improved antibacterial effect, accelerated recovery, and increased concentration Effect

Inactive Publication Date: 2019-03-12
沧州爱农生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the treatment of vaginal and uterine diseases in pigs and sheep, vaginal and uterine perfusion are often used, but the overall therapeutic effect is not ideal due to the poor solubility of the above dosage forms and the small contact area with the uterine mucosa and vagina.

Method used

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  • Compound occrycetin, dried alum and borneol effervescent tablet and preparation method thereof
  • Compound occrycetin, dried alum and borneol effervescent tablet and preparation method thereof
  • Compound occrycetin, dried alum and borneol effervescent tablet and preparation method thereof

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preparation example Construction

[0035] The present invention also provides a preparation method of the above-mentioned compound oxytetracycline hydrochloride borneol effervescent tablet, comprising the following steps:

[0036] a) Oxytetracycline hydrochloride, dry alum, borneol, tartaric acid, citric acid, and micropowder silica gel are pulverized through a 100-mesh sieve, and set aside;

[0037] b) Sodium bicarbonate, sodium carbonate, polyvinylpyrrolidone, and low-substituted hydroxypropyl cellulose are pulverized through a 100-mesh sieve, and set aside;

[0038] c) After mixing the material obtained in step a) and the material obtained in step b), spraying sewage ethanol to obtain soft material;

[0039] d) adding the soft material obtained in step c) to a granulator to granulate, and drying at 35-55°C;

[0040] e) granulate the granules obtained in step d), and add magnesium stearate and mix uniformly;

[0041] f) Put the granules obtained in step e) into a tablet press, and press them into tablets, t...

Embodiment 1

[0049] The compound oxytetracycline hydrochloride dry borneol effervescent tablet comprises the following raw materials in parts by weight:

[0050]1600 parts of oxytetracycline hydrochloride, 220 parts of dry alum, 170 parts of borneol, 600 parts of tartaric acid, 50 parts of citric acid, 1300 parts of sodium bicarbonate, 130 parts of sodium carbonate, 300 parts of polyvinylpyrrolidone, 70 parts of micropowdered silica gel, 50 parts of low Instead of hydroxypropyl cellulose, 30 parts magnesium stearate.

[0051] The preparation method of compound oxytetracycline hydrochloride borneol effervescent tablet comprises the following steps:

[0052] a) Oxytetracycline hydrochloride, dry alum, borneol, tartaric acid, citric acid, and micropowder silica gel are pulverized through a 100-mesh sieve, and set aside;

[0053] b) Sodium bicarbonate, sodium carbonate, polyvinylpyrrolidone, and low-substituted hydroxypropyl cellulose are pulverized through a 100-mesh sieve, and set aside;

...

Embodiment 2

[0059] The compound oxytetracycline hydrochloride dry borneol effervescent tablet comprises the following raw materials in parts by weight:

[0060] 2000 parts of oxytetracycline hydrochloride, 150 parts of dry alum, 130 parts of borneol, 800 parts of tartaric acid, 80 parts of citric acid, 1000 parts of sodium bicarbonate, 170 parts of sodium carbonate, 150 parts of polyvinylpyrrolidone, 130 parts of micropowdered silica gel, 80 parts of low Instead of hydroxypropyl cellulose, 10 parts magnesium stearate.

[0061] The preparation method of compound oxytetracycline hydrochloride borneol effervescent tablet comprises the following steps:

[0062] a) Oxytetracycline hydrochloride, dry alum, borneol, tartaric acid, citric acid, and micropowder silica gel are pulverized through a 100-mesh sieve, and set aside;

[0063] b) Sodium bicarbonate, sodium carbonate, polyvinylpyrrolidone, and low-substituted hydroxypropyl cellulose are pulverized through a 100-mesh sieve, and set aside; ...

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Abstract

The invention discloses a compound occrycetin, dried alum and borneol effervescent tablet and a preparation method thereof. The compound occrycetin, dried alum and borneol effervescent tablet is characterized in that the dried alum has the functions of astringing self, stopping bleeding, promoting tissue regeneration and detoxifying, the borneol has the functions of eliminating swelling, relivingpain and detoxifying, and the dried alum and borneol are combined with the occrycetin, so as to enhance the detoxifying function of the compound occrycetin, dried alum and borneol effervescent tablet,relieve the injury to wounds by toxin, reduce the pain caused by the inflammation diminishing function of the occrycetin in the treatment process, and reach the effects of healing up sore, promotingtissue regeneration, and accelerating restoration of uterus. Because of the particular effervescent disintegrating drug-release characteristic, the compound occrycetin, dried alum and borneol effervescent tablet is especially suitable for the local administration of vagina and uterus, the contact area of drug with the inflammation part is effectively increased, and the concentration of drug at thelocal part is increased; compared with the common occrycetin local preparation, the antibacterial effect is obviously improved.

Description

technical field [0001] The invention relates to the field of effervescent tablets, in particular to a compound oxytetracycline hydrochloride borneol effervescent tablet and a preparation method thereof. Background technique [0002] In recent years, with the development of pig and sheep breeding industry, vaginal and uterine diseases such as endometritis, vaginitis, pyometra, postpartum infection, and retained placenta caused by pathogenic microorganisms such as bacteria, fungi, mycoplasma, and viruses have gradually The increase will cause huge economic losses to the pig and sheep breeding industry. Therefore, it is urgent to strengthen the prevention and treatment of pig and sheep vaginal and uterine diseases to ensure the healthy and sustainable development of the pig and sheep breeding industry, thereby improving the economic benefits of the pig and sheep breeding industry. [0003] The chemical name of oxytetracycline hydrochloride is 6-methyl-4-(dimethylamino)-3,5,6,10...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K9/46A61K47/12A61K47/02A61K47/32A61K47/38A61K47/04A61P15/00A61P15/02A61P31/02A61K31/65A61K31/045
CPCA61K9/0007A61K9/0034A61K9/2009A61K9/2013A61K9/2027A61K9/2054A61K31/045A61K31/65A61K33/06A61P15/00A61P15/02A61P31/02A61K2300/00
Inventor 毕煌成周忠良张志英李章军金彩莲尚洪亮吴永刚夏晓辉李秀军张伟涛王红张亮姚宝红
Owner 沧州爱农生物科技有限公司
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