Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of degradable medical bacteriostatic biological film with bleeding-stopping function

A biomedical and preparation step technology, applied in the field of medical films, can solve the problems of poor hemostatic effect and poor degradability, and achieve the effects of being easy to obtain, promoting tissue growth and having a wide range of sources.

Inactive Publication Date: 2019-03-22
赵顺全
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main technical problem to be solved by the present invention is to provide a method for preparing a degradable hemostatic and antibacterial biomedical film for the defects of existing biomedical films, such as poor antibacterial, hemostatic effect, and poor degradability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029] Put shrimp shells and crab shells into a grinder and grind them for 20 minutes to obtain ground powder. Put the ground powder and hydrochloric acid with a mass fraction of 5% into the reaction kettle according to the mass ratio of 1:2, and stir for 1 hour. Add a sodium hydroxide solution with a mass fraction of 5% in the kettle, adjust the pH to 8, stir and react for 1 hour, add hydrochloric acid with a mass fraction of 5% in the reactor, adjust the pH to be neutral, and obtain a mixed solution; mix the above Liquid, potassium permanganate, and sodium bisulfite are mixed according to the mass ratio of 3:1:1, then poured into the stirrer, stirred for 20 minutes, then put into the oven, set the temperature in the oven to 60°C, and dried for 1 hour to obtain the carapace. element; the above-mentioned chitin, lithium chloride, and dimethylacetamide solution with a mass fraction of 30% are poured into a stirrer in a mass ratio of 12:1:20, and stirred for 20 min to obtain a vi...

example 2

[0031] Put shrimp shells and crab shells into a grinder and grind for 25 minutes to obtain ground powder. Put the ground powder and hydrochloric acid with a mass fraction of 5% into the reactor at a mass ratio of 1:2, and stir for 2 hours. Add a sodium hydroxide solution with a mass fraction of 5% in the kettle, adjust the pH to 8, stir and react for 2 hours, add hydrochloric acid with a mass fraction of 5% in the reactor, adjust the pH to be neutral, and obtain a mixed solution; mix the above solution, potassium permanganate, and sodium bisulfite in a mass ratio of 3:1:1, poured into a stirrer, stirred for 25 minutes, put into an oven, set the temperature in the oven to 65°C, and dried for 1 hour to obtain carapace. element; the above-mentioned chitin, lithium chloride, and dimethylacetamide solution with a mass fraction of 30% are poured into a stirrer in a mass ratio of 12:1:20, and stirred for 25 min to obtain a viscous liquid, and to the viscous liquid Add viscous liquid ...

example 3

[0033] Put shrimp shells and crab shells into a grinder and grind for 30 minutes to obtain ground powder. Put the ground powder and hydrochloric acid with a mass fraction of 5% into the reaction kettle at a mass ratio of 1:2, and stir for 3 hours. Add a sodium hydroxide solution with a mass fraction of 5% in the kettle, adjust the pH to 9, stir and react for 3 hours, add hydrochloric acid with a mass fraction of 5% in the reactor, adjust the pH to be neutral, and obtain a mixed solution; mix the above solution, potassium permanganate, and sodium bisulfite are mixed according to the mass ratio of 3:1:1, poured into the mixer, stirred for 30 minutes, put into the oven, set the temperature in the oven to 70°C, and dried for 2 hours to obtain the carapace. element; the above-mentioned chitin, lithium chloride, and dimethylacetamide solution with a mass fraction of 30% are poured into a stirrer in a mass ratio of 12:1:20, and stirred for 30 minutes to obtain a viscous liquid. Add v...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a degradable medical bacteriostatic biological film with a bleeding-stopping function, and belongs to the technical field of medical films. The preparation method comprises the following steps of firstly, using shrimp shells and crab shells as raw materials to prepare chitosan fiber; using gamma-polyglutamic acid, n-butyl bromide, allyl bromide, tetrahydrofuran and the like as the raw materials to prepare a hydrogel; mixing the chitosan fiber and the hydrogel to react, thus the active groups at the surface of the chitosan fiber and the active groups at the surface of the hydrogel can produce hydrogen bond attraction force, and the chitosan fiber and the hydrogel are combined together, so as to obtain the modified hydrogel; putting the modified hydrogel into a high-pressure electrostatic spinning device, so as to obtain a composite nanometer fiber film; treating the composite nanometer fiber film in a hot press way, so as to obtain the degradable medical bacteriostatic biological film with the bleeding-stopping function. The degradable medical bacteriostatic biological film with the bleeding-stopping function has the advantages that the degrading time is short, the bleeding stopping time is greatly shortened, the good bleeding-stopping effect is realized, and the bacteriostatic effect on escherichia coli, staphylococcus aureus andcandida albicans is realized; the application prospect is broad.

Description

technical field [0001] The invention discloses a preparation method of a degradable hemostatic and antibacterial biomedical membrane, which belongs to the technical field of medical membranes. Background technique [0002] According to reports, 90% of surgical procedures will lead to different degrees of adhesions. The sequelae of postoperative tissue adhesions are: persistent pain at the surgical site, postoperative adhesions, partial loss of function, and increased difficulty in reoperation and the potential for complications. In surgery, products to prevent postoperative adhesions are still in urgent need of the market. [0003] Surgical anti-adhesion film, also known as absorbable medical film, is an ultra-thin and comfortable semi-permeable film. It has the characteristics of good waterproof, anti-bacteria, breathable, hypoallergenic, transparent, high elasticity, etc., and can be degraded into CO within the expected time 2 and H 2 O and other small molecules are ab...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/14
CPCA61L31/042A61L31/06A61L31/14A61L31/145A61L31/148A61L2400/04C08L5/08C08L77/04
Inventor 赵顺全陈珺丁春美
Owner 赵顺全
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com