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Mesoporous biological glass-loaded small intestinal submucosa wound surface dressing

A technology of small intestinal submucosa and bioglass, which is applied in the fields of biomedical engineering and skin wound repair materials, can solve the problems of single structure and cannot give full play to the excellent performance of SIS, and achieves improved antibacterial, stable and controllable manufacturing process, and large-scale production. production effect

Active Publication Date: 2019-03-26
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dressing products have a single structure and cannot give full play to the excellent performance of SIS

Method used

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  • Mesoporous biological glass-loaded small intestinal submucosa wound surface dressing
  • Mesoporous biological glass-loaded small intestinal submucosa wound surface dressing
  • Mesoporous biological glass-loaded small intestinal submucosa wound surface dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of small intestinal submucosa matrix material: the small intestinal submucosa was degreased, enzymatically hydrolyzed, descaled, freeze-dried, and low-temperature ball milled to obtain small intestinal submucosa powder; SIS powder with a mass fraction of 2.5% was dissolved in 0.01M hydrochloric acid At the same time, 0.25% pepsin was added, and magnetically stirred at room temperature for 48 hours; after SIS was completely dissolved, SIS was neutralized by 0.1M NaOH solution, and stored at 4°C.

[0031] (2) Preparation of copper and zinc mesoporous bioglass:

[0032] Add 1.5% 0.5M HCl by volume to absolute ethanol, add 10% ethyl orthosilicate, 2% calcium nitrate tetrahydrate, 0.5% copper chloride, 1.5% triethyl phosphate, 8% P 123, stirred magnetically at room temperature for 48 hours; transferred the solution to a petri dish and let it stand for gelation, and completed the self-assembly process of solvent volatilization, and obtained dry gel after 24 ho...

Embodiment 2

[0040] (1) Preparation of small intestinal submucosa matrix material: The small intestinal submucosa was degreased, enzymatically hydrolyzed, descaled, freeze-dried, and low-temperature ball milled to obtain small intestinal submucosa powder; SIS powder with a mass fraction of 1% was dissolved in 0.01 M hydrochloric acid At the same time, 0.1% pepsin was added, and magnetically stirred at room temperature for 36 hours; after SIS was completely dissolved, SIS was neutralized with 0.1 M NaOH solution, and stored at 4°C.

[0041] (2) Preparation of copper and zinc mesoporous bioglass:

[0042] Add 1.5% 0.5M HCl by volume to absolute ethanol, then add 8% ethyl orthosilicate, 1.5% calcium nitrate tetrahydrate, 2.5% copper chloride, 1.0% triethyl phosphate, 7% P 123 , magnetic stirring at room temperature for 44 hours; transfer the solution to a petri dish and let it stand for gelation, complete the self-assembly process of solvent volatilization, and obtain dry gel after 28 hours; ...

Embodiment 3

[0049] (1) Preparation of small intestinal submucosa matrix material: the small intestinal submucosa was degreased, enzymatically hydrolyzed, descaled, freeze-dried, and low-temperature ball milled to obtain small intestinal submucosa powder; the SIS powder with a mass fraction of 5% was dissolved in 0.01 M hydrochloric acid At the same time, 0.5% pepsin was added, and magnetically stirred at room temperature for 48 hours; after SIS was completely dissolved, SIS was neutralized by 0.1M NaOH solution, and stored at 4°C.

[0050] (2) Preparation of copper and zinc mesoporous bioglass:

[0051] Add 1.5% 0.5M HCl by volume to absolute ethanol, add 12% ethyl orthosilicate, 2.5% calcium nitrate tetrahydrate, 3% copper chloride, 2.0% triethyl phosphate, 9% P 123 , magnetic stirring at room temperature for 52 hours; transfer the solution to a petri dish and let it stand for gelation, complete the solvent volatilization self-assembly process, and obtain the xerogel after 30 hours; take...

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Abstract

The invention provides a method for preparing copper / zinc mesoporous biological glass-loaded small intestinal submucosa wound surface dressing through a low-temperature three-dimensional printing technique. The method is characterized by comprising the following steps: (1) preparing a small intestinal submucosa (SIS) matrix material; (2) preparing copper and zinc mesoporous biological glass (Cu-MGB / Zn-MGB); (3) compositing SIS with Cu-MGB / Zn-MGB; (4) preparing a wound surface dressing based on the low-temperature three-dimensional printing technique; and (5) carrying out after-treatment process. The SIS wound surface dressing has the advantages that the SIS wound surface dressing has excellent efficacies of resisting bacteria, stopping bleeding, promoting vascularization and accelerating the regeneration rate of the wound surface; the customization design and production can be realized according to different clinic demands; the cost is low, the manufacturing process is stable and controllable, and the large-scale production can be realized; and the wound surface dressing can be stored for a long time and is convenient to use.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, in particular to the technical field of skin wound repair materials, and in particular relates to a small intestine submucosa wound dressing loaded with mesoporous bioglass. Background technique [0002] Extensive skin trauma has always been a difficult clinical problem. According to the strategy of skin tissue engineering regenerative treatment, the use of artificial dressings to accelerate the rate of wound repair and improve the effect of wound repair has great market prospects. Even, to a certain extent, it can replace the current mainstream skin flap transplantation technology, reducing the patient's pain, surgical risk and economic burden. [0003] The choice of matrix material is crucial for the manufacture of wound dressings. At present, many natural or synthetic biomaterials have begun to be used in the field of wound repair materials, such as sodium alginate, gelatin, c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00B33Y80/00B33Y10/00
CPCA61L26/0004A61L26/0057A61L26/0066A61L26/0085A61L2300/102A61L2300/30A61L2300/404B33Y10/00B33Y80/00
Inventor 熊蠡茗石磊王文天胡益强张祥林
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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