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Composite collagen dressing for burnt injury wound surface restoration and preparation method thereof

A technology of wound repair and collagen, applied in medical science, bandages, absorbent pads, etc., can solve the problems of limited repair effect and no obvious advantages in removing scars, and achieve the effect of speeding up repair

Active Publication Date: 2019-04-26
BEIJING QINGYUAN WEIYE BIO TISSUE ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Collagen-based wound repair products currently on the market mainly include spongy, fibrous, and powdery wound repair materials, etc., and their ingredients are generally a single type of type I collagen or a compound of type I collagen and other medical polymers. Limited, and no significant benefit for scar removal
There is no wound repair material prepared by compounding multiple types of collagen on the market

Method used

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  • Composite collagen dressing for burnt injury wound surface restoration and preparation method thereof
  • Composite collagen dressing for burnt injury wound surface restoration and preparation method thereof
  • Composite collagen dressing for burnt injury wound surface restoration and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 6

[0052] Rat materials in Experimental Example 6 were purchased from the Experimental Animal Center of Tianjin Medical University.

[0053] The 1st group of embodiment, the present invention is used for the composite collagen dressing of wound surface of human body

[0054] The embodiment of this group provides a composite collagen dressing for human body wound repair. All the examples in this group have the following common features: they are formed by mixing and compounding two or more different types of collagen.

[0055] In some embodiments, the different types of collagen are selected from the group consisting of collagen type I, collagen type III, collagen type V;

[0056] The type I collagen is derived from pigskin, cowhide, bovine Achilles tendon;

[0057] The type III collagen is derived from human or animal blood vessel walls, uterine walls, and amniotic membranes;

[0058] The type V collagen is derived from human or animal amniotic membrane, serous membrane and pl...

experiment example 1

[0093] Experimental Example 1: Preparation of Spongy Formulation

[0094] (1) Weigh collagen types I, III, and V, disperse them in distilled water according to the ratio of 95.4:3.82:0.78 (W / W / W), and mix and homogenize with a high-speed mixer;

[0095] (2) Place the homogenate in a certain container, then pre-freeze it in a -80°C ultra-low temperature refrigerator for 24 hours, and then dry it in a -50°C freezer vacuum dryer for 24 hours;

[0096] (3) Take out the loose and porous spongy collagen material after freeze-drying, and cut it into different shapes and sizes according to application requirements.

experiment example 2

[0097] Experimental Example 2: Preparation of Micropowder

[0098] (1) Weigh collagen types I, III, and V, disperse them in distilled water according to the ratio of 93.65:6.32:1.03 (W / W / W), and mix and homogenize with a high-speed mixer;

[0099] (2) Place the homogenate in a certain container, place it in a vacuum drying oven for vacuum defoaming for 2 hours, and then dry it in a freezer vacuum dryer at -50°C for 24 hours;

[0100] (3) Pulverizing the freeze-dried composite collagen material into small pieces, placing it in a liquid nitrogen grinder, setting a grinding program according to the particle size of the required micropowder, and performing liquid nitrogen grinding;

[0101] (4) The composite collagen micropowder after liquid nitrogen grinding treatment is placed in a vacuum dryer for several hours at low temperature and vacuum drying to obtain a composite collagen micropowder material.

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Abstract

The invention discloses a composite collagen dressing for burnt injury wound surface restoration and a preparation method thereof. 99.9 to 85 parts of type I collagen, 0.01 to 10 parts of type III collagen and 0.01 to 5 parts of type V collagen are proportionally dispersed into a solvent; after homogenizing, shaping is performed; a finished product is obtained. Related ingredients are selected from different kinds of multi-ingredient collagen materials of different contents; no foreign materials are introduced; low immunogenicity and good biocompatibility are realized; the characteristics of all collagen ingredients are sufficiently achieved; the wound restoration is accelerated; the wound healing quality is improved.

Description

technical field [0001] The invention belongs to the field of biomaterials, and in particular relates to a composite collagen dressing for wound repair, especially burn wound repair, and a preparation method thereof. Background technique [0002] The skin covers the surface of the body and is the largest organ in the human body. The skin accounts for about 16% of the adult body weight, with a total area of ​​about 1.2-2.0m 2 .Burns are divided into superficial burns and deep burns. Large-area burns seriously damage the shape and function of the skin. The persistent existence of wounds is the root cause of complications such as shock, water and electricity imbalance, and infection. Burns are mainly related to local skin damage and loss of skin barrier function. Only by covering the wound in time and effectively can the purpose of treatment be achieved. [0003] Wound repair is an inherent preventive adaptive response of the body to tissue and cell damage and defects caused b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/22A61L15/42A61L15/44
CPCA61L15/225A61L15/42A61L15/44A61L2300/252A61L2300/412C08L89/00
Inventor 李志宏郭雅楠王微
Owner BEIJING QINGYUAN WEIYE BIO TISSUE ENG
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