Degradable drug-eluting stent with hydrophobic structure on surface and manufacturing method thereof

Abstract

The invention discloses a degradable drug eluting stent with the surface provided with a hydrophobic structure and a making method, belongs to the technical field of medical apparatus and instruments,and relates to a design and making method of a hydrophobic degradable drug eluting stent with a micro-structure arranged on the surface in application to the field of vascular interventional medicine. The stent structure is composed of a waveform basic support unit, a straight bar connection unit, a left arc connection unit and a right arc connection unit. Uniformly distributed micro columns aremachined on the single face or double faces of the stent by adopting injection molding or extrusion molding which is matched with the laser engraving or 3D printing technology; the stent has the functions of hydrophobicity, drag reduction, biological self-cleaning and the like. A drug elusion coating is processed through a spraying or soaking method. The stent has good supportability and flexibility, the hydrophobic micro-structure on the surface can also effectively slow down the elution effect of blood flow to drugs in the coating, aggregation and adsorption of an extracellular matrix and platelets around the stent are reduced, and then the risk of restenosis in the stent is reduced.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to a design and manufacturing method of a hydrophobic degradable drug-eluting stent with a microstructure on the surface, which is applied in the field of vascular interventional medicine. Background technique [0002] Millions of people die from cardiovascular diseases every year in the world, and vascular stent technology is an effective means to treat vascular stenosis diseases. Once the bare metal stents that appeared in the early stage are implanted in the living body, they cannot be taken out again, and will permanently accompany the living body as a foreign body, which greatly increases the safety hazard of the living body. Afterwards, degradable polymer scaffolds appeared, which are now widely used because the final degradation products in vivo are carbohydrates. However, severe in-stent restenosis will occur within a few months after stenting, and a coating containin...

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Problems solved by technology

[0003] Secondly, the drug-loaded stent in the blood vessel will cause part of the drug to be lost with the blood under the elution of the blood flow, which greatly reduces the effective drug release time.

At the same time, in the process of stent implantation, the damage in the lumen will induce the immune inflammatory response, resulting in the proliferation of smooth muscle cells, resulting in thrombus, which increases the probability of postoperative restenosis in the stent

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