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Injectable self-healing hydrogel with conductivity and preparation method thereof

A conductive and self-healing technology, applied in medical science, prosthesis, etc., can solve the problems of unsatisfactory mechanical properties and rheological properties, and can not be used as an ideal injectable material, so as to promote rapid healing and cross-linking process Controllable, pain-avoiding effects

Active Publication Date: 2019-05-14
四川创智炜业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the unsatisfactory mechanical and rheological properties of the hydrogel formed by natural polymers, it cannot be used as an ideal injectable material to play its due role in the application of sustained drug release and tissue engineering.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve 10 parts by mass of gelatin in 100 parts by mass of phosphate buffer solution with pH=7.4 at 55°C, add 2 parts by mass of methacrylic anhydride dropwise, stir for 1 hour, dialyze the mixed solution and freeze-dry to obtain Methacrylic anhydride-modified gelatin; 10 mass parts of methacrylic anhydride-modified gelatin was dissolved in 100 mass parts of phosphate buffer solution with pH=7.4 at 50°C, and 5 mass parts of pyrrole were added at room temperature, and stirred for 2 After 2 h, add 2 mass parts of ammonium persulfate, continue stirring for 15 h, and finally dialyze the mixed solution and freeze-dry to obtain polypyrrole grafted gelatin; when using, dissolve 2 mass parts of polypyrrole grafted gelatin in 12 mass parts In the phosphate buffer solution of 7.4, add dropwise 6 parts by mass of FeCl with a concentration of 0.5M 3 solution, an injectable self-healing hydrogel with conductive properties can be formed within 10 s.

Embodiment 2

[0022] Dissolve 10 parts by mass of collagen in 100 parts by mass of phosphate buffer solution with pH=7.4 at 4°C, add 4 parts by mass of methacrylic anhydride dropwise, stir for 1 hour, dialyze the mixed solution and freeze-dry to obtain Collagen modified with methacrylic anhydride; Dissolve 10 parts by mass of collagen modified with methacrylic anhydride in 100 parts by mass of phosphate buffer at pH=7.4 at 4°C, add 7 parts by mass of pyrrole at room temperature, and stir for 1.5 After 1 h, add 1 mass part of potassium persulfate, continue stirring for 20 h, and finally dialyze the mixed solution and freeze-dry to obtain polypyrrole grafted collagen; when using, dissolve 2 mass parts of polypyrrole grafted collagen in 10 mass parts of pH = In the phosphate buffer solution of 7.4, add 4 parts by mass of FeCl with a concentration of 0.8M dropwise 3 solution, an injectable self-healing hydrogel with conductive properties can be formed within 20 s.

Embodiment 3

[0024] Dissolve 10 parts by mass of alginic acid in 1000 parts by mass of ultrapure water at 6 °C, add dropwise 200 parts by mass of methacrylic anhydride, stir for 3 h, dialyze the mixed solution and freeze-dry to prepare methacrylic anhydride Modified alginic acid: Dissolve 10 parts by mass of methacrylic anhydride modified alginic acid in 1000 parts by mass of ultrapure water at 6 °C, add 6 parts by mass of pyrrole at room temperature, stir for 3 h, then add 3 parts by mass of over Potassium sulfate, continue to stir for 16 h, finally dialyze the mixed solution, and freeze-dry to prepare polypyrrole-grafted alginic acid; when using, dissolve 2 mass parts of polypyrrole-grafted alginic acid in 12 mass parts of ultrapure water, add dropwise 4 parts by mass of FeCl with a concentration of 0.2M 3 solution, an injectable self-healing hydrogel with conductive properties can be formed within 25s.

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Abstract

The invention relates to injectable self-healing hydrogel with conductivity and a preparation method thereof. The method comprises the steps that firstly, a methacrylic anhydride modified natural polymer is adopted, then, pyrrole is added into a modified natural polymer solution, stirring is performed for 1-3 h, then, an initiator is added, and after a reaction is ended, dialysis and freeze dryingare performed to obtain a polypyrrole grafted natural polymer; then, the polypyrrole grafted natural polymer is dissolved into ultra pure water, and then, due to the Fe3+ cross linking effect, the injectable self-healing hydrogel with the conductivity is prepared. The prepared self-healing hydrogel has the advantages of conductivity and injectability, the hydrogel can be implanted into the body in a minimally invasive mode, the irregular defect part is restored, and meanwhile wound healing is promoted. The injectable self-healing hydrogel has the potential application prospect in the field ofbiology medicine materials.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an injectable self-healing hydrogel with electrical conductivity, good biocompatibility and rapid wound healing and a preparation method thereof. Background technique [0002] Hydrogel is a kind of soft material containing a large amount of water obtained by crosslinking hydrophilic polymers. It has excellent physical and chemical properties and biological characteristics. In the fields of biomedical research such as drug delivery and tissue engineering, hydrogel has great potential. important application value. In recent years, injectable hydrogels have aroused widespread interest among scholars. Generally speaking, injectable hydrogels are liquid or semi-solid with shear thinning properties before injection into the human body, and can be gelled in situ after injection into the human body, so invasive surgery is not required, effectively avoiding reduce the risk ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/52A61L27/58A61L27/50C08J3/075C08G73/06C08H1/00C08B37/04C08B31/04
Inventor 穆畅道王绅李德荣易雪玲刘翊
Owner 四川创智炜业科技有限公司
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