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Extracellular matrix high-polymer material biological composite patch

A technology of polymer material and composite patch, applied in the field of extracellular matrix polymer material biocomposite patch, can solve the problems of limited source, premature degradation, uncertain degradation time, etc., so as to avoid immune response and improve tissue quality. Compatibility, the effect of satisfying mechanical properties

Inactive Publication Date: 2019-05-17
太阳雨林(厦门)生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] (2) Degradable material patch: PLGA patch, PCL patch and other degradable synthetic polymer compounds, as well as polymer compounds extracted from natural substances, such as gelatin, chitosan, hyaluronic acid, etc. patch, the degradation time is uncertain, and there is a problem of premature degradation;
[0007] (4) Human-derived patch: the source is extremely limited

Method used

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  • Extracellular matrix high-polymer material biological composite patch
  • Extracellular matrix high-polymer material biological composite patch
  • Extracellular matrix high-polymer material biological composite patch

Examples

Experimental program
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Embodiment 1

[0028] A biocomposite patch of extracellular matrix polymer material, which is composed of a dense polymer nanofiber layer close to the peritoneal side during surgery and a porous scaffold layer covering the dense polymer nanofiber layer. The porous scaffold layer consists of The porous scaffold and the substances secreted by the above-mentioned human-derived cells adhered, grown and propagated in the porous scaffold include various collagens, elastin, aminoglycans, hyaluronic acid, fibronectin and laminin Consisting of an interconnected extracellular matrix of proteins, which does not contain immunogenic cellular components, the pores of the porous scaffold are sized to allow cells to grow in, and the pores communicate with each other to allow the above-mentioned extracellular matrix to interconnect. The method for removing the above-mentioned immunogenic cellular components is mechanical method, enzymatic digestion method or detergent method.

[0029] Preferably: the thickne...

Embodiment 2

[0035] The appearance of the extracellular matrix polymer biocomposite patch prepared in this example is as follows: figure 1 Shown, its preparation method is specifically as follows:

[0036] (1) Dissolving PCL and gelatin in hexafluoroisopropanol to obtain an electrospinning stock solution, the specific parameters of which are shown in Table 1 below:

[0037] Table 1 Electrospinning solution preparation parameters

[0038]

[0039] (2) Electrospinning the above-mentioned electrospinning stock solution to obtain such figure 2 The dense polymer nanofiber layer shown; the specific parameters of electrospinning are shown in Table 2 below:

[0040]Table 2 Electrospinning parameter control

[0041]

[0042]

[0043] (3) Evenly smear the prepared foaming solution on the upper surface of the dense polymer nanofiber layer prepared in step (2), pre-freeze at -80°C, and then freeze and vacuum dry at -4°C for 24h to obtain Such as image 3 Porous support; the composition...

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Abstract

The invention discloses an extracellular matrix high-polymer material biological composite patch which consists of a compact high-polymer nanofiber layer clinging to the peritoneal side during operation and a porous stent layer covering the compact high-polymer nanofiber layer. The biological composite patch contains human-derived components, avoids immune reaction, improves tissue compatibility,meanwhile can provide good compliance well matched with abdominal wall tissues and meet mechanical properties required by the composite patch. Normal human tissue cells can grow into it without scar formation.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular relates to a biocomposite patch of extracellular matrix polymer material. Background technique [0002] A hernia means that a certain organ or tissue in the human body leaves its normal anatomical position and enters another part through a congenital or acquired weak point, defect or hole. Common hernias include umbilical hernia, direct inguinal hernia, indirect hernia, incisional hernia, surgical recurrence hernia, linea alba hernia, femoral hernia, etc. Abdominal wall hernias are often caused by increased intra-abdominal pressure due to coughing, sneezing, excessive force, abdominal obesity, forced defecation, pregnancy, excessive crying in children, and degenerative changes in the strength of the abdominal wall in the elderly, forcing free organs in the abdominal cavity such as: small intestine, cecum, The omentum, bladder, ovary, fallopian tube and other organs enter...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/36A61L27/56A61L27/50A61F2/00
Inventor 赵一麟周媛媛
Owner 太阳雨林(厦门)生物医药有限公司
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