Dextromethorphan hydrobromide sustained-release suspension and preparation method thereof

Abstract

The invention discloses a dextromethorphan hydrobromide sustained-release suspension. The suspension is prepared from, by mass, 85-95% of a suspension matrix, 0.5-1.5% of coated resin, 0.1-0.5% of drug-loaded resin, 0.01-0.08% of EDTA, 0.1-0.3% of a surface active agent and the balance water, wherein the drug-loaded resin is prepared from a dextromethorphan hydrobromide crude drug, sodium polystyrenesulfonate type cation exchange resin and purified water; the coated resin is prepared from impregnating resin, dichloromethane, vegetable oil, ethyl cellulose and acetone, and the impregnating resin is prepared from polyethylene glycol, purified water and the prepared drug-loaded resin. The invention further discloses a preparation method of the dextromethorphan hydrobromide sustained-release suspension. The sustained-release effect is good, the drug treating effect is lasting, the treatment effect is good, the number of drug applying times can be obviously reduced, the problems that a solid sustained-release preparation is poor in taste, difficult to swallow and inaccurate in fractional dose are solved, and the dextromethorphan hydrobromide sustained-release suspension is convenient for children patients to take.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a dextromethorphan hydrobromide sustained-release suspension and a preparation method thereof. Background technique [0002] At present, among the more than 3,500 kinds of chemical preparations in my country, 90% of the medicines do not have dosage forms for children, and less than 100 kinds are specially used for children. And there are fewer liquid preparations for children. Among the only less than 10% of children's medicines, most of them are also imported or produced by joint ventures. Many domestic drug manufacturers refer to clinical research reports done abroad or only give general dosage conversion methods. In this way, it is difficult for tablets or capsule solid preparations to adapt to sub-dose. Conventional suspensions or oral liquids often need three times a day, which is extremely unfavorable for children who go to kindergarten or go to school. Therefore, in ...

AI Technical Summary

Problems solved by technology

[0002] At present, among the more than 3,500 kinds of chemical preparations in my country, 90% of the medicines do not have dosage forms for children, and less than 100 kinds are specially used for children.

In this way, it is difficult for tablets or capsule solid preparations to adapt to sub-dose

However, conventional suspensions or oral liquids often need three times a day, which is extremely unfavorable for children who go to kindergarten or go to school.

Therefore, in order to overcome the problems of solid preparations such as taste discomfort, difficulty in swallowing, and inaccurate dosage, as well as to facilitate the taking of medicine and enhance the therapeutic effect of children, an oral liquid sustained and controlled release preparation with better sustained release effect and therapeutic effect was developed. very important