Compound for preventing and controlling alcoholic poisoning and preparation method thereof

A technology of alcohol poisoning and compounds, applied in the field of traditional Chinese medicine, can solve problems such as application limitations, achieve stable properties, reduce extraction solvent consumption and energy consumption, and stabilize active ingredients

Pending Publication Date: 2019-05-28
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are three main drugs commonly used in the treatment of alcoholism/alcohol dependence, which are naltrexone, campral, and disulfiram, but they all have serious side effects, such as producing

Method used

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  • Compound for preventing and controlling alcoholic poisoning and preparation method thereof
  • Compound for preventing and controlling alcoholic poisoning and preparation method thereof
  • Compound for preventing and controlling alcoholic poisoning and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A compound for preventing and treating alcoholism, characterized in that any of the following six compounds, the structural formula of which is as follows:

[0047]

[0048] Among them compound one: R 1 =OCH 3 , R 2 =OCH 3 , R 3 =OH,R 4 =OH,R 5 =H,R 6 =OCH 3 ;

[0049] Compound 2: R 1 =OCH 3 , R 2 =OH,R 3 =H,R 4 =OH,R 5 =H,R 6 =OCH 3 ;

[0050] Compound Three: R 1 =OCH 3 , R 2 =OCH 3 , R 3 =H,R 4 =H,R 5 =H,R 6 = H;

[0051] Compound Four: R 1 =OCH 3 , R 2 =OH,R 3 =H,R 4 =H,R 5 =H,R 6 = H;

[0052] Compound five: R 1 =OCH 3 , R 2 =OH,R 3 =OCH 3 , R 4 =H,R 5 =H,R 6 = H;

[0053] Compound Six: R 1 =H,R 2 =OH,R 3 =H,R 4 =H,R 5 =OCH 3 , R 6 =OCH 3 .

[0054] A method for preparing a compound for preventing and treating alcoholism, comprising the following steps:

[0055] ⑴ After manual selection, cleaning and impurity removal of the whole medicinal herb, dry it indoors in the shade to obtain a dried sample of the whole h...

Embodiment 2

[0062] A compound for preventing and treating alcoholism, characterized in that any of the following six compounds, the structural formula of which is as follows:

[0063]

[0064] Among them compound one: R 1 =OCH 3 , R 2 =OCH 3 , R 3 =OH,R 4 =OH,R 5 =H,R 6 =OCH 3 ;

[0065] Compound 2: R 1 =OCH 3 , R 2 =OH,R 3 =H,R 4 =OH,R 5 =H,R 6 =OCH 3 ;

[0066] Compound Three: R 1 =OCH 3 , R 2 =OCH 3 , R 3 =H,R 4 =H,R 5 =H,R 6 = H;

[0067] Compound Four: R 1 =OCH 3 , R 2 =OH,R 3 =H,R 4 =H,R 5 =H,R 6 = H;

[0068] Compound five: R 1 =OCH 3 , R 2 =OH,R 3 =OCH 3 , R 4 =H,R 5 =H,R 6 = H;

[0069] Compound Six: R 1 =H,R 2 =OH,R 3 =H,R 4 =H,R 5 =OCH 3 , R 6 =OCH 3 .

[0070] A method for preparing a compound for preventing and treating alcoholism, comprising the following steps:

[0071] ⑴ After manual selection, cleaning and impurity removal of the whole herb, the whole herb is dried indoors to obtain a dry sample of the whole herb, whi...

Embodiment 3

[0078] A compound for preventing and treating alcoholism, characterized in that any of the following six compounds, the structural formula of which is as follows:

[0079]

[0080] Among them compound one: R 1 =OCH 3 , R 2 =OCH 3 , R 3 =OH,R 4 =OH,R 5 =H,R 6 =OCH 3 ;

[0081] Compound 2: R 1 =OCH 3 , R 2 =OH,R 3 =H,R 4 =OH,R 5 =H,R 6 =OCH 3 ;

[0082] Compound Three: R 1 =OCH 3 , R 2 =OCH 3 , R 3 =H,R 4 =H,R 5 =H,R 6 = H;

[0083] Compound Four: R 1 =OCH 3 , R 2 =OH,R 3 =H,R 4 =H,R 5 =H,R 6 = H;

[0084] Compound five: R 1 =OCH 3 , R 2 =OH,R 3 =OCH 3 , R 4 =H,R 5 =H,R 6 = H;

[0085] Compound Six: R 1 =H,R 2 =OH,R 3 =H,R 4 =H,R 5 =OCH 3 , R 6 =OCH 3 .

[0086] A method for preparing a compound for preventing and treating alcoholism, comprising the following steps:

[0087] ⑴ After manual selection, cleaning and impurity removal of the whole herb, the whole herb is dried indoors to obtain a dry sample of the whole herb, whi...

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Abstract

The invention relates to a compound for preventing and controlling alcoholic poisoning and a preparation method thereof. The method comprises the following steps that (1) medicinal material herb is subjected to manual picking, cleaning and impurity removal; then, indoor drying in shade is performed to obtain dry herb samples; through crushing and sieving, medicinal material powder is obtained; (2)the medicinal material powder is subjected to leaching by ethanol; leaching liquid is subjected to grinding by a colloid mill, high-pressure homogenization and centrifugal separation to obtain supernatant and filter slag; (3) the supernatant passes through macroporous resin to be adsorbed and is eluted by an ethanol solution; an obtained alcohol solution is concentrated to extractum; after extraction by petroleum ether, ethyl acetate and n-butyl alcohol, each extraction part is collected; (4) the extraction parts are treated by MCI and repeated silica gel columns; a two-dimensional reversal phase/hydrophilic chromatographic analysis preparation method is combined; a monomer compound is obtained; (5) on the basis of gamma-aminobutyric acid protein A receptor, the monomer compound is subjected to alcoholic poisoning and alcohol dependence resistant activity screening; through animal behavior experiments such as righting reflex losing tests, rotating rod tests and motion coordination tests, six active compounds are screened and prepared. The technology design is scientific and reasonable; the cost is low; the extraction rate and the preparation efficiency are high; the obtained compound has stable property; the content is high; a high alcoholic poisoning and alcohol dependence resistant effect is achieved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a compound for preventing and treating alcoholism and a preparation method thereof. technical background [0002] The scientific name of snow ganoderma is Gansu flea (Arenaria kansuensis Maxim.), which is a perennial cushion-like herbaceous plant of Caryophyllaceae. Snow Ganoderma lucidum uses the whole herb as medicine. Its nature and flavor are bitter and cold. It has the effects of clearing away heat and benefiting lungs, relieving cough, dispelling swelling, lowering blood pressure, clearing stranguria and relieving pain. It is often used in the treatment of jaundice, gonorrhea, uterine disease, pneumonia and various lung diseases. Central Asian aster (Asterothamnus centrali-asiaticus) is a plant of the Asteraceae family. It mainly grows in grasslands and desert areas at an altitude of 1,300 meters to 3,900 meters. Due to its high nutritional value, it is...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40A61K31/352A61P39/02
Inventor 刘增根崔玉磊党军岳会兰赵建强邵贇陶燕铎
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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