A degradable rhenium nanocluster for ct imaging and photothermal therapy and its preparation method and application

A nanocluster, photothermal therapy technology, applied in the field of nanomaterials, can solve problems such as degradation and oxidation, and achieve the effects of mild conditions, good dispersion and stability, and improved safety.

Active Publication Date: 2021-10-15
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when the size of rhenium is reduced to the nanometer level, rhenium nanoparticles can be oxidized by oxygen, which has the possibility of degradation
So far, rhenium is mainly used as an alloy material or a nanocatalyst, and there is no application of rhenium nanoparticles in photothermal therapy and CT imaging.

Method used

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  • A degradable rhenium nanocluster for ct imaging and photothermal therapy and its preparation method and application
  • A degradable rhenium nanocluster for ct imaging and photothermal therapy and its preparation method and application
  • A degradable rhenium nanocluster for ct imaging and photothermal therapy and its preparation method and application

Examples

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Embodiment 1

[0035] This embodiment prepares rhenium nanoclusters as follows:

[0036] (1) Weigh 100 mg of ammonium perrhenate and 45 mg of mercaptopolyethylene glycol and dissolve in 25 mL of deionized water, stir for 20 min to obtain solution A;

[0037] (2) Dissolve 150 mg of sodium borohydride in 5 mL of deionized water and pre-cool at 4°C to obtain solution B;

[0038] (3) Add solution B to solution A, and stir for 2 hours at room temperature;

[0039] (4) The obtained product is subjected to ultrafiltration and centrifugation at a centrifugation speed of 4500 rpm and a centrifugation time of 15 minutes to obtain degradable rhenium nanoclusters.

[0040] figure 2 It is the transmission electron microscope image of rhenium nanoclusters, and its characterization method is as follows: drop the water dispersion liquid of rhenium nanoclusters on the copper grid of the transmission electron microscope, dry it, put it into the transmission electron microscope for observation, and the part...

Embodiment 2

[0049] This embodiment prepares rhenium nanoclusters as follows:

[0050] (1) Weigh 100 mg of ammonium perrhenate and 100 mg of bovine serum albumin and dissolve in 25 mL of deionized water, stir for 20 min to obtain solution A;

[0051] (2) Dissolve 150 mg of sodium borohydride in 5 mL of deionized water and pre-cool at 4°C to obtain solution B;

[0052] (3) Add solution B to solution A, and stir for 2 hours at room temperature;

[0053] (4) The obtained product is subjected to ultrafiltration and centrifugation at a centrifugation speed of 4500 rpm and a centrifugation time of 15 minutes to obtain degradable rhenium nanoclusters.

[0054] Through characterization and testing, the rhenium nanoclusters in this example have a particle size of 1-3 nm, have the functions of CT contrast-enhanced diagnosis and photothermal therapy, and have biodegradable properties.

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Abstract

The invention discloses a degradable rhenium nanocluster used for CT imaging and photothermal treatment and its preparation method and application. The component is an ultra-small rhenium nanocluster modified by a stabilizer with a size of 1-3nm. The metal nano-preparation of the present invention is biodegradable, and can be converted into water-soluble perrhenate ions under the action of hydrogen peroxide molecules in the body, and excreted through the kidneys, which improves the safety of clinical application; and because at the same time With strong near-infrared absorption and X-ray attenuation capabilities, the preparation can be used for photothermal therapy and CT contrast imaging respectively, realizing the effective combination of disease diagnosis and treatment.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a degradable rhenium nanocluster for CT imaging and photothermal therapy and a preparation method. Background technique [0002] Cancer is one of the major diseases that seriously threaten human health. Clinically, there are currently three main treatment techniques for cancer: surgical resection, radiation therapy, and chemotherapy. However, due to the different sites and mechanisms of cancer and the high heterogeneity of most cancer tissues, these three treatment techniques currently have certain limitations in clinical practice, which reduces the final cancer treatment effect. Therefore, the development of new cancer treatment technologies can make up for the deficiencies of current clinical treatment technologies, and is expected to improve the survival period and quality of life of cancer patients. Photothermal therapy technology is a new type of cancer t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K41/00A61P35/00A61P29/00A61P17/00
Inventor 缪昭华马艳陆杨查正宝
Owner HEFEI UNIV OF TECH
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