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Hydroxyapatite nano-column self-assembled microsphere and preparation method thereof

A technology of hydroxyapatite and nanocolumns, which is applied in the field of self-assembled microspheres of hydroxyapatite nanocolumns and its preparation, and can solve the problems of EDTA being not environmentally friendly

Active Publication Date: 2019-06-04
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Literature (QianjunHe, Zhiliang Huang, Yu Liu, et al.Template-directed one-step synthesis offlowerlike porous carbonated hydroxyapatite spheres) reported that sodium ethylenediaminetetraacetic acid (Na 2 EDTA) was used as a template, and hydroxyapatite microspheres were prepared under hydrothermal conditions, with a particle size of about 20 μm, but the synthesis process used Na 2 EDTA is not environmentally friendly
Literature (Ming-GuoMa, Jie-Fang Zhu.Solvothermal Synthesis and Characterization of Hierarchically Nanostructured Hydroxyapatite HollowSpheres) reported the preparation of hydroxyapatite hollow microspheres by solvothermal method, but the carcinogenic component N,N-dimethyl Formamide

Method used

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  • Hydroxyapatite nano-column self-assembled microsphere and preparation method thereof

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Embodiment 1

[0037] A method for preparing hydroxyapatite nanocolumn self-assembled microspheres, comprising the steps of:

[0038]Add 12.00g of stearic acid to 12.00g of ethanol, and dissolve the stearic acid completely at a water bath temperature of 50°C under stirring conditions; add 20ml of 1.00g of sodium hydroxide dropwise at a water bath temperature of 50°C under stirring conditions Aqueous solution, after the addition of sodium hydroxide aqueous solution is completed, the reaction temperature is raised to 65°C; in a water bath at a temperature of 65°C, under stirring conditions, add 20ml of an aqueous solution containing 0.22g of calcium chloride dropwise to form a calcium stearate precursor; cool down to 50°C, add 10ml of an aqueous solution containing 0.2368g of sodium tripolyphosphate dropwise at a water bath temperature of 50°C under stirring conditions, and after the aqueous solution of sodium tripolyphosphate has been added dropwise, transfer the reaction solution to water at ...

Embodiment 2

[0041] A method for preparing hydroxyapatite nanocolumn self-assembled microspheres, comprising the steps of:

[0042] Add 12.00g of stearic acid to 12.00g of ethanol, and dissolve the stearic acid completely at a water bath temperature of 50°C under stirring conditions; add 20ml of 1.00g of sodium hydroxide dropwise at a water bath temperature of 50°C under stirring conditions Aqueous solution, after the addition of sodium hydroxide aqueous solution is completed, the reaction temperature is raised to 65°C; in a water bath at a temperature of 65°C, under stirring conditions, add 20ml of an aqueous solution containing 0.22g of calcium chloride dropwise to form a calcium stearate precursor; cool down to 50°C, add 10ml of an aqueous solution containing 0.2368g of sodium tripolyphosphate dropwise at a water bath temperature of 50°C under stirring conditions, and after the aqueous solution of sodium tripolyphosphate has been added dropwise, transfer the reaction solution to water at...

Embodiment 3

[0044] A method for preparing hydroxyapatite nanocolumn self-assembled microspheres, comprising the steps of:

[0045] Add 12.00g of stearic acid to 12.00g of ethanol, and dissolve the stearic acid completely at a water bath temperature of 50°C under stirring conditions; add 20ml of 1.00g of sodium hydroxide dropwise at a water bath temperature of 50°C under stirring conditions Aqueous solution, after the addition of sodium hydroxide aqueous solution is completed, the reaction temperature is raised to 65°C; in a water bath at a temperature of 65°C, under stirring conditions, add 20ml of an aqueous solution containing 0.22g of calcium chloride dropwise to form a calcium stearate precursor; cool down to 50°C, add 10ml of an aqueous solution containing 0.2368g of sodium tripolyphosphate dropwise at a water bath temperature of 50°C under stirring conditions, and after the aqueous solution of sodium tripolyphosphate has been added dropwise, transfer the reaction solution to water at...

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Abstract

The invention provides a hydroxyapatite nano-column self-assembled microsphere and a preparation method thereof. The preparation method comprises the following steps: dissolving stearic acid into ethanol, and respectively dropwise adding a strong alkali water solution, a water-soluble calcium salt aqueous solution and a tripolyphosphate aqueous solution so as to obtain a white viscous reaction solution; and carrying out a solvothermal reaction at 160-200 DEG C for 20-36 hours so as to obtain the hydroxyapatite nano-column self-assembled microsphere. The non-toxic and pollution-free stearic acid is used as a reactive soft template agent, the special micro-morphology hydroxyapatite nano-column self-assembled microsphere with a large specific surface area, uniform size and appropriate particle size is obtained under the synergistic effect of the stearic acid and tripolyphosphate, and the special micro-morphology hydroxyapatite nano-column self-assembled microsphere has a relatively wide application prospect. The preparation method is simple in process, easy to operate and low in energy consumption, the raw materials are cheap and easy to obtain, green and environment-friendly effectsare achieved, and the cost is low.

Description

technical field [0001] The invention relates to a hydroxyapatite nanocolumn self-assembled microsphere and a preparation method thereof, belonging to the field of inorganic biomedical materials. Background technique [0002] As the main inorganic component of human bones and teeth, hydroxyapatite (HA or HAP) has excellent biological activity, biocompatibility, osteoconductivity, adsorption and good biodegradability, etc. , so it can be widely used in biomedical fields such as bone replacement, drug loading and gene loading. [0003] According to different synthesis methods, hydroxyapatite with different crystallinity, size and shape can be prepared, and different structures endow hydroxyapatite with different application characteristics, thus enabling hydroxyapatite to be applied in many fields. Among the numerous hydroxyapatite structures, the microsphere-shaped hydroxyapatite not only has the characteristics of good rheology of microspheres, but also has the advantages of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00
Inventor 肖桂勇王银川吕宇鹏徐伟莉张文钰
Owner SHANDONG UNIV
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