Magnetic silica filler, magnetic affinity filler and preparation method and application of magnetic affinity filler

A silicon dioxide and magnetic technology, which is applied in the field of magnetic affinity filler and its preparation, can solve the problems of uncontrollable particle size and pore size, easy disappearance of magnetism, and high temperature resistance, etc., and achieves a simple introduction method, not easy to demagnetize, and not easy to leak Effect

Inactive Publication Date: 2019-06-11
PEKING UNIV SHENZHEN GRADUATE SCHOOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The currently prepared magnetic silica microspheres have the following disadvantages: most of them have a particle size of only a few hundred nanometers, their particle size and pore size are uncontrollable, and most of the structures are core-shell structures, and the magnetic nanoparticles are not uniformly dispersed in the silica skeleton. In the structure; the magnetic particles are mostly Fe 3 o 4 , which needs to be prepared in advance, which is troublesome, and it is not resistant to high temperature, easy to oxidize, and the magnetism is easy to disappear

Method used

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  • Magnetic silica filler, magnetic affinity filler and preparation method and application of magnetic affinity filler
  • Magnetic silica filler, magnetic affinity filler and preparation method and application of magnetic affinity filler
  • Magnetic silica filler, magnetic affinity filler and preparation method and application of magnetic affinity filler

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preparation example Construction

[0041] The present invention provides a kind of preparation method of magnetic silicon dioxide filler, and this method comprises the following steps:

[0042] Sulfonate the porous polymer microspheres;

[0043] Combining sulfonated porous polymer microspheres with Fe 3+ and Fe 2+ The iron source contacts to adsorb Fe 3+ and Fe 2 + , the Fe in this iron source 3+ :Fe 2+ Molar ratio = 2:1, add ammonia water after the adsorption is completed, and generate magnetic Fe in situ 3 o 4 / polymer microspheres;

[0044] A silicon source is added to the magnetic Fe 3 o 4 In the polymer microspheres, the sol-gel reaction is carried out to obtain the magnetic Fe 3 o 4 / High molecular polymer / silica composite microspheres;

[0045] The magnetic Fe 3 o 4 / Magnetic Fe in High Molecular Polymer / Silica Composite Microspheres 3 o 4 In situ oxidation to γ-Fe 2 o 3 , get γ-Fe 2 o 3 / High molecular polymer / silica composite microspheres;

[0046] The γ-Fe 2 o 3 The high-molec...

Embodiment 1

[0055] Embodiment 1: Preparation of magnetic silica filler

[0056] Weigh 20 g of magnetic silica filler polyglycidyl methacrylate / ethylene glycol dimethacrylate (PGMA / EGDMA) microspheres with a particle size of 7.42 μm, ultrasonically disperse them in 500 ml of water, add 20 g of sodium sulfite, and dissolve them at 160 rpm The reaction was mechanically stirred for 24h. After the reaction, filter with suction, wash with water and ethanol three times respectively to obtain sulfonated porous PGMA / EGDMA microspheres, and dry them in an oven at 50°C for future use.

[0057] Weigh 1.645g FeCl 2 4H 2 O and 4.34 g FeCl 3 ·6H 2 O was dissolved in 20ml of water, and vacuumized to prepare Fe 2+ :Fe 3+ Iron source solution with a molar ratio of 1:2, N 2 Save it for future use. Ultrasonic disperse 0.5 g of the sulfonated 7.42 μm porous PGMA / EGDMA microspheres prepared above in 20 ml of water, add 0.5 ml of the prepared iron source solution, and after 12 hours of adsorption, direc...

Embodiment 2

[0062] Embodiment 2: Preparation of magnetic silica filler

[0063]Weigh 20g of magnetic silica filler polystyrene / divinylbenzene (PS / DVB) microspheres with a particle size of 4.54μm, ultrasonically disperse them in 500ml of water, add 20g of sodium sulfite, and react with mechanical stirring at 160rpm for 24h. After the reaction, filter with suction, wash with water and ethanol three times respectively to obtain sulfonated porous PS / DVB microspheres, and dry them in an oven at 50°C for future use.

[0064] Weigh 1.645g FeCl 2 4H 2 O and 4.34 g FeCl 3 ·6H 2 O was dissolved in 20ml of water, and vacuumized to prepare Fe 2+ :Fe 3+ Iron source solution with a molar ratio of 1:2, N 2 Save it for future use. Ultrasonic disperse 0.5 g of the sulfonated 4.54 μm porous PS / DVB microspheres prepared above in 20 ml of water, add 0.125 ml of the prepared iron source solution, and after 12 hours of adsorption, directly add 1 ml of 28% by weight ammonia water to the solution, Stir m...

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Abstract

The invention relates to the technical field of magnetic nano materials, and particularly relates to a preparation method of magnetic silica filler. The preparation method comprises the following steps: taking porous high-molecular polymer microspheres as a template, introducing Fe3O4 magnetic nanoparticles in situ, carrying out a sol-gel reaction on a silicon source, then oxidizing the magnetic Fe3O4 in situ to be gamma-Fe2O3, and carrying out high-temperature calcining to prepare magnetic silica filler magnetic silicon dioxide microspheres. The magnetic silicon dioxide filler magnetic silicon dioxide microspheres prepared by the method is controllable in particle size and pore size, the magnetic particles are gamma-Fe2O3 and are uniformly dispersed in a silicon dioxide skeleton structure. The magnetic silica filler is further applied, and heparin modification is carried out on the magnetic silica filler to prepare magnetic affinity filler which can be used for separating and purifying antithrombin III.

Description

technical field [0001] The invention relates to the technical field of magnetic nanomaterials, in particular to a method for preparing a magnetic silica filler and the prepared magnetic silica filler, and also to a magnetic affinity filler containing the magnetic silica filler and its preparation Methods and uses. Background technique [0002] Porous silica has the characteristics of high specific surface area, high mechanical strength, good stability, good biocompatibility and easy modification. Magnetic nanoparticles can be separated from the liquid phase or transported to specific parts under the action of an external magnetic field. They are widely used in the fields of adsorption separation, chemical catalysis, and targeted drug delivery. Subject to certain restrictions. Combining porous silica and magnetic nanoparticles to prepare composite materials can overcome these shortcomings, and at the same time, the advantages of porous silica and magnetic nanoparticles will...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/10B01J20/28B01J20/30B01D15/38C07K14/81C07K1/22
Inventor 何洁陈继伟
Owner PEKING UNIV SHENZHEN GRADUATE SCHOOL
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