Magnetic iron oxide and elemental selenium nano composite particles and preparation method and application thereof

A technology of magnetic iron oxide and composite particles, applied in the direction of elemental selenium/tellurium, pharmaceutical formulations, drug combinations, etc., can solve the problems of limited antibacterial effect, achieve enhanced penetration ability, good biocompatibility, and simple preparation process.

Pending Publication Date: 2019-06-21
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because of the penetration problem, the antibacterial effect of selenium on bacterial biofilms with a thickness of 10 μm is very limited.

Method used

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  • Magnetic iron oxide and elemental selenium nano composite particles and preparation method and application thereof
  • Magnetic iron oxide and elemental selenium nano composite particles and preparation method and application thereof
  • Magnetic iron oxide and elemental selenium nano composite particles and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Preparation of magnetic iron oxide nanoparticles: 0.15 g of low molecular weight chitosan (deacetylation degree of 75%-85%) was dissolved in 30 mL of 1% acetic acid solution, and the pH value was adjusted with 1.0 mol / L NaOH. to 4.8. Add 1.34gFeCl 2 4H 2 O and 3.40 g FeCl 3 ·6H 2 O in the above chitosan solution. The mixture was vigorously stirred, and 30 mL of 25% ammonia water and 10 mL of 0.75% TPP solution were added successively. The reaction was continued at 50° C. for 1 h, and the whole reaction was carried out under the condition of deoxygenation and nitrogen flow. After the reaction, the crude product was washed three times with deionized water, centrifuged and magnetically separated, and freeze-dried to obtain a solid magnetic iron oxide sample, which was confirmed by XRD to be magnetic ferric oxide with a particle size of 7.0-12.3nm.

[0034] (2) Preparation of magnetic iron oxide and elemental selenium nanocomposite particles; mix 8 mL of 0.07 mol / ...

Embodiment 2

[0038] (1) Preparation of magnetic iron oxide nanoparticles: same as in Example 1.

[0039] (2) Preparation of magnetic iron oxide and elemental selenium nanocomposite particles; mix 8 mL of 0.05 mol / L sodium selenite solution with 32 mL of 0.05 mol / L GSH solution, and shake at room temperature for 15 min on a platform shaker at a speed of 300rpm. Then, 100 mg of freeze-dried magnetic iron oxide nanoparticles were added, and the shaking was continued for 15 min. Add 3.5mL mol / L NaOH solution, the pH value of the solution is 11.73, and continue the reaction at 250rpm for 3h. The crude product was washed three times with deionized water, subjected to centrifugation and magnetic separation, and freeze-dried to obtain a solid composite microparticle sample.

[0040] Figure 4 It is a transmission electron microscope picture of magnetic iron oxide and elemental selenium nanocomposite particles. The elemental selenium is in the shape of a rod, and the fine particles with lighter ...

Embodiment 3

[0042] (1) Preparation of magnetic iron oxide nanoparticles: same as in Example 1.

[0043] (2) Preparation of magnetic iron oxide and elemental selenium nanocomposite particles; mix 8mL 0.01mol / L sodium selenite solution with 32mL 0.01mol / L GSH solution, shake on a platform shaker for 15min at a speed of 300rpm . Then, 50 mg of freeze-dried magnetic iron oxide nanoparticles were added, and the shaking was continued for 15 min. Add 3.5mL mol / L NaOH solution, the pH value of the solution is 11.73, and continue the reaction at 250rpm for 3h. The crude product was washed three times with deionized water, subjected to centrifugation and magnetic separation, and freeze-dried to obtain a solid composite microparticle sample.

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Abstract

The invention belongs to the field of biological materials, and particularly provides magnetic iron oxide and elemental selenium nano composite particles and a preparation method and application thereof. The preparation method comprises the following steps: adding chitosan-stable magnetic iron oxide nano particles into a mixed solution of sodium selenite and glutathione to obtain a solid compositeparticle crude product under the effect of an alkaline catalyst, carrying out centrifugal separation and magnetic separation, and then freeze-drying to obtain the magnetic iron oxide and elemental selenium nano composite particles. The preparation method is simple and easy to operate, the composite particles simultaneously contains elemental selenium nano particles and magnetic iron oxide nano particles, the two materials have antibacterial property and biocompatibility, and under the action of an external magnetic field, magnetic iron oxide, together with element selenium in the composite particles, can permeate into a bacterial biofilm together, so that the treatment effect on the biofilm is obviously enhanced, and the composite particles can be widely applied to various medical fields.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a magnetic iron oxide and element selenium nanocomposite particle, a preparation method and application thereof. Background technique [0002] Today, bacterial infections are considered a major problem affecting the world's healthcare systems. When a patient undergoes surgery or orthopedic implants, bacteria can enter the wound from the patient's skin or mucous membranes, causing bacterial infection or implant failure. Even more serious is the tendency for bacteria to form a biofilm after contacting a surface. Once formed, bacterial biofilms prevent drugs such as antibiotics from penetrating inside the biofilm, making antibiotic therapy less effective or completely ineffective. [0003] In response to this problem, bio-nanotechnology has developed rapidly, and antibacterial nanoparticles are gradually replacing antibiotics to eliminate bacterial drug resistance. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K41/00A61K9/00A61K47/36A61P31/04A61P35/00C01B19/02A61K33/04
Inventor 黎珊林富荣秦勇陶永新孔泳彭勇刚
Owner CHANGZHOU UNIV
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