Benzopyrone skeleton derivative, preparation method and uses thereof
A technology of benzopyrone and derivatives, which is applied in the field of chemical pharmacy, can solve the problems of reducing bile discharge, toxicity, and poor selectivity, and achieve the effects of increasing sensitivity, reversing drug resistance, and simple structure
Active Publication Date: 2019-06-21
FUDAN UNIV
2 Cites 1 Cited by
AI-Extracted Technical Summary
Problems solved by technology
View more
Abstract
The invention belongs to the field of chemical pharmacy, and relates to a benzopyrone skeleton derivative, a preparation method and uses thereof, particularly to a derivative with a 2-ethyl benzopyrone bicyclic mother nucleus containing 7-alkoxy and 8-aromatic acid or an aromatic hydrocarbon acid methanol ester substituted derivative. According to the present invention, the experiment results showthat the derivative is almost non-toxic to normal cells and drug-resistant tumor cells, can significantly reverse the drug-resistant activity of P-gp overexpressing A2780/T and KB-V to drugs by combining with paclitaxel and vincristine, does not improve the drug sensitivity of P-gp-dependent drug-resistant tumor cells, and can establish the foundation in the obtaining of the sensitizer capable ofrestoring the drug sensitivity of MDR tumors caused by P-gp overexpression and the overcoming of tumor MDR caused by P-gp overexpression.
Application Domain
Organic chemistryAntineoplastic agents
Technology Topic
PaclitaxelNormal cell +12
Image
Examples
- Experimental program(7)
Example Embodiment
Example Embodiment
Example Embodiment
PUM


Description & Claims & Application Information
We can also present the details of the Description, Claims and Application information to help users get a comprehensive understanding of the technical details of the patent, such as background art, summary of invention, brief description of drawings, description of embodiments, and other original content. On the other hand, users can also determine the specific scope of protection of the technology through the list of claims; as well as understand the changes in the life cycle of the technology with the presentation of the patent timeline. Login to view more.
Similar technology patents
Magnetic cooling apparatus and control method thereof
Owner:SAMSUNG ELECTRONICS CO LTD
Controllable bi-circulating hot-pipe system
Owner:QINGDAO UNIV
Electronic cigarette and a wireless charging device for the same
Owner:KIMREE HI TECH
Dual-Drivetrain of Power-Assist Vehicle
Owner:CHOU WEN CHENG
Classification and recommendation of technical efficacy words
- Simple structure
- reverse drug resistance
Sharing system for air-conditioning coat
Owner:QINGDAO HAIER AIR CONDITIONER GENERAL CORP LTD
Temperature-fixing dehumidifying air conditioner and control method thereof
Owner:HAIER GRP CORP +1
Nozzle transmission mechanism for 3D printer and 3D printer with same
Owner:J H TECH ELECTRONICS GZ LTD
Feeding device of sorter of batteries plate
Owner:NANJING NORMAL UNIVERSITY
Emergency parachuting device and method for multiple-rotor unmanned aerial vehicle
Owner:SOUTH CHINA AGRI UNIV +1