Composite hydrogel material and preparation method thereof

A composite hydrogel and hydrogel technology, applied in the field of biomedical materials, can solve the problems of hydrogel application limitations, achieve superior water absorption, good ventilation, and promote wound healing

Inactive Publication Date: 2019-06-28
KUNMING UNIV OF SCI & TECH
View PDF2 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the preparation process of current hydrogels, most of them use cross-linking agents such as glutaraldehyde, glycidyl ether, vinyl sulfone, etc., but they all have certain toxicity, and the residue of cross-linking agents will make the hydrogel suffer from damage in application. very restrictive

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composite hydrogel material and preparation method thereof
  • Composite hydrogel material and preparation method thereof
  • Composite hydrogel material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A composite hydrogel material is a spongy hydrogel material compounded by polyvinyl alcohol, chitosan and sodium hyaluronate.

[0032] The preparation method of this composite hydrogel material, concrete steps are as follows:

[0033] (1) According to chitosan and dilute acetic acid The solid-to-liquid ratio g:mL is the ratio of 1:50, chitosan is added to the dilute acetic acid whose mass percent concentration is 1%, magnetic stirring is mixed evenly, and mixture A is obtained;

[0034] (2) Dissolve sodium hyaluronate in deionized water according to the solid-to-liquid ratio g:mL of sodium hyaluronate and deionized water is 1:50, and mix evenly with magnetic stirring to obtain mixture B;

[0035] (3) According to mixture A and The volume ratio of mixture B is 1:2, and mixture A in step (1) is added to mixture B in step (2) to obtain mixture C;

[0036] (4) Using phosphoric acid with a mass fraction of 5% to adjust the pH value of the mixture C in step (3) to 2, and ...

Embodiment 2

[0042] A composite hydrogel material is a spongy hydrogel material compounded by polyvinyl alcohol, chitosan and sodium hyaluronate.

[0043] The preparation method of this composite hydrogel material, concrete steps are as follows:

[0044] (1) According to chitosan and dilute acetic acid The solid-liquid ratio g:mL is the ratio of 1:80, chitosan is added in the dilute acetic acid that mass percent concentration is 0.5%, magnetic stirring is mixed uniformly, obtains mixture A;

[0045] (2) Dissolve sodium hyaluronate in deionized water according to the solid-to-liquid ratio g:mL of sodium hyaluronate and deionized water is 1:100, and mix evenly with magnetic stirring to obtain mixture B;

[0046] (3) According to mixture A and The volume ratio of mixture B is 1:3, and mixture A in step (1) is added to mixture B in step (2) to obtain mixture C;

[0047] (4) Using phosphoric acid with a mass fraction of 10% to adjust the pH value of the mixture C in step (3) to 1, and magne...

Embodiment 3

[0054] A composite hydrogel material is a spongy hydrogel material compounded by polyvinyl alcohol, chitosan and sodium hyaluronate.

[0055] The preparation method of this composite hydrogel material, concrete steps are as follows:

[0056] (1) According to chitosan and dilute acetic acid The solid-liquid ratio g:mL is the ratio of 1:100, chitosan is added in the dilute acetic acid that mass percent concentration is 3%, magnetic stirring is mixed uniformly, obtains mixture A;

[0057] (2) Dissolve sodium hyaluronate in deionized water according to the solid-to-liquid ratio g:mL of sodium hyaluronate and deionized water is 1:80, and mix evenly with magnetic stirring to obtain mixture B;

[0058] (3) According to mixture A and The volume ratio of mixture B is 1:0.5, and mixture A in step (1) is added to mixture B in step (2) to obtain mixture C;

[0059] (4) Using phosphoric acid with a mass fraction of 8% to adjust the pH value of the mixture C in step (3) to 4, and magnet...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
elastic modulusaaaaaaaaaa
Login to view more

Abstract

The invention discloses a composite hydrogel material and a preparation method thereof. The composite hydrogel material is a sponge-shaped hydrogel material prepared through the compositing of polyvinyl alcohol, chitosan and sodium hyaluronate. Chitosan and sodium hyaluronate are taken as the raw materials, polyvinyl alcohol is added, and physically cross-linked polyvinyl alcohol / chitosan / sodium hyaluronate composite hydrogel is prepared by virtue of a freezing and thawing cycle method. The preparation process is short in flow, the method is simple and convenient, and the prepared composite hydrogel contains natural polysaccharide chitosan and has active mold resistance; and the hydrogel material has good mechanical properties, tenacity and biocompatibility and can be degraded in a livingbody, and the physically cross-linked hydrogel material has huge application potentials in the fields of artificial skin, skin dressings, medicine carrying, cartilage repair, cancellous bone micro-defects and the like.

Description

technical field [0001] The invention relates to a composite hydrogel material and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] Polyurethane, or polyurethane (PU), is a general term for polymers containing repeated carbamate groups (-NHCOO-) in their molecular structure. Polyurethane has gradually been recognized by people for its wide range of softness and hardness, low temperature resistance, good flexibility, and strong adhesion. The dressing made of polyurethane will reduce the adhesion of the skin, which is different from the natural polymer hydrogel. In comparison, there are problems such as incompatibility with the skin, poor degradation performance, and easy to cause secondary damage to the wound. [0003] Hydrogel is a three-dimensional network polymer that can absorb a large amount of water without dissolving. It is a kind of functional polymer material that integrates water absorption, water ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08L29/04C08J3/075
Inventor 冷崇燕竹泳俊汪虹支燕严继康
Owner KUNMING UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap