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Photo-cured medical catheter hydrophilic lubrication coating and preparation method thereof

A technology for lubricating coatings and medical catheters, applied in the direction of catheters, coatings, pharmaceutical formulations, etc., to achieve the effects of fast UV curing speed, excellent super-hydrophilicity, and good adhesion

Active Publication Date: 2019-07-05
ORBUSNEICH MEDICAL SHENZHEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The technical problem to be solved by the present invention is to provide a light-cured medical catheter hydrophilic lubricating coating and its preparation method according to the current state of the art, which solves the problems of adhesion, lubricity, durability, rapid curing, etc. Problem, the fast-curing hydrophilic coating endows medical catheters with good hydrophilic properties, good adhesion, and long-lasting lubricity

Method used

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  • Photo-cured medical catheter hydrophilic lubrication coating and preparation method thereof
  • Photo-cured medical catheter hydrophilic lubrication coating and preparation method thereof
  • Photo-cured medical catheter hydrophilic lubrication coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Primer coating configuration: Weigh 2.0g of 6-functionality polyester acrylic resin, 0.4g of hydroxyethyl methacrylate, 0.15g of polyether modified organosiloxane, photoinitiator 2-hydroxy-2-methylpropiophenone 0.3g, 24g of absolute ethanol, placed in a brown bottle, magnetically stirred for 2 hours, filtered through a 500-mesh nylon gauze to obtain a mixed solution of the bottom coating.

[0056] Lubricating coating configuration: Weigh 1.0g of polyvinylpyrrolidone, 0.4g of polyvinyl alcohol pyridine, 0.2g of polyethylene glycol, 0.1g of polyethylene oxide, 12g of water, and 31.3g of absolute ethanol, and place them in a brown bottle. Stir magnetically for 1-3 hours, and filter through a 500-mesh nylon gauze to obtain a lubricating coating mixed solution.

Embodiment 2

[0058] Primer coating configuration: Weigh 1.0g of 3-functionality polyester acrylic resin, 1.0g of 6-functionality polyester acrylic resin, 0.4g of hydroxyethyl methacrylate, 0.15g of polyether modified organosiloxane, photoinitiator 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (IRGACURE 2959) 0.3g, absolute ethanol 24g, placed in a brown bottle, magnetically stirred for 2h, passed through a 500-mesh nylon gauze Filtrate to obtain the bottom coating mixed solution.

[0059] Lubricating coating configuration: Weigh 1.0g of polyvinylpyrrolidone, 0.4g of polyvinyl alcohol pyridine, 0.2g of polyethylene glycol, 12g of water, and 31.3g of absolute ethanol, place them in a brown bottle, and stir them magnetically for 1-3h. Filter through a 500-mesh nylon gauze to obtain a lubricating coating mixed solution.

Embodiment 3

[0061] Primer coating configuration: Weigh 1.0g of 3-functionality polyester acrylic resin, 0.4g of 6-functionality polyester acrylic resin, 0.6g of vinylpyrrolidone, 0.15g of polyether modified organosiloxane, photoinitiator 2-hydroxy -4'-(2-hydroxyethoxy)-2-methylpropiophenone (IRGACURE 2959) 0.3g, absolute ethanol 24g, placed in a brown bottle, magnetically stirred for 2h, filtered through a 500-mesh nylon gauze to obtain Undercoating mix solution.

[0062] Lubricating coating configuration: Weigh 1.0g of polyvinylpyrrolidone, 0.4g of polyvinyl alcohol pyridine, 8.4g of water, and 31.3g of absolute ethanol, place them in a brown bottle, stir them magnetically for 1-3 hours, and pass through a 500-mesh nylon gauze Filter to obtain a lubricating coating mixed solution.

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Abstract

The invention discloses a photo-cured medical catheter hydrophilic lubrication coating and a preparation method thereof. The hydrophilic lubrication coating comprises a bottom coating and a lubrication coating, wherein the bottom coating is attached to the surface of an instrument, and the lubrication coating is attached to the bottom coating. The bottom coating comprises 1-10 parts of polyester acrylate, 50-90 parts of solvents, 0.5-5 parts of photoinitiators, 0.5-2 parts of wetting agents and 0.5-5 parts of reactive diluents; the lubrication coating comprises 1-10 parts of water soluble macromolecules, 1-5 parts of crosslinking macromolecules, 0-1 part of photoinitiators, 0.1-1 part of surfactants and 50-98 parts of mixed solvents. The preparation method of the hydrophilic lubrication coating is simple and easy in operation, substance residues caused by complicated high-temperature chemical reaction are avoided, the cured coating forms a crosslinking structure, has good adhesion on the surface of a medical catheter and has excellent and lasting lubricity in an aqueous medium, the friction coefficient of the surface of the medical catheter is reduced, and harm to human tissues andadhesion of macromolecules in blood are decreased.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a light-cured hydrophilic lubricating coating for medical catheters and a preparation method thereof. Background technique [0002] Interventional therapy catheters are widely used in clinical treatment. Many short-term or long-term devices that are in contact with human tissues, such as balloon catheters, guide catheters, guide wires, etc., will rub against the contacted tissues when they are inserted or pulled out, causing the device It is difficult to enter the designated lesion site, which is not conducive to surgical operation, and may cause adverse reactions such as tissue damage and inflammation. In order to reduce the risk of surgery and alleviate the pain of patients, various lubricating coatings have been developed for medical catheters. In recent years, people have turned their research focus to water-soluble and biocompatible hydrophilic lubricating coatings....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/14A61L29/18
CPCA61L29/085A61L29/08A61L29/14A61L29/18A61L2400/18A61L2420/02A61L2420/08A61L2420/06C08L67/06C08L39/06C08L29/04C08L71/02A61L2400/10B05D5/08B05D7/542B05D3/067B05D2201/00B05D2254/02C10N2040/50C10N2050/023B05D3/10C10M107/32C10M107/34C10M107/42C10M155/02C10M169/041C10M2209/1023C10M2209/1045C10M2217/0285C10M2229/02
Inventor 朱靖静徐松云李勉彭畅龚伊容
Owner ORBUSNEICH MEDICAL SHENZHEN CO LTD
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