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Preparing method of hybridization metal organic framework compound for drug release

A metal-organic framework and compound technology, applied in the field of preparation of hybrid metal-organic framework compounds, can solve the problems of target drug waste, complex preparation process and high production cost, and achieve low production cost, simple preparation process and high load capacity. Effect

Inactive Publication Date: 2019-07-09
HENAN INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, from the perspective of its drug loading method, it first synthesizes the metal organic framework compound, loads the drug molecules into the pores of the metal organic framework compound, and then coats the surface of the metal organic framework compound with a polymer β-cyclodextrin shell layer, the preparation-then-loading-re-coating method is complicated to prepare, and the production process often causes waste of target drugs, resulting in high production costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of a hybrid metal organic framework compound for drug release, the steps are as follows:

[0029] (1) Dissolve doxorubicin in deionized water, stir to dissolve, and prepare solution A;

[0030] (2) Dissolve zinc nitrate in deionized water, stir to dissolve, and prepare solution B;

[0031] (3) Dissolving dopamine hydrochloride in a 40 mass % ethanol aqueous solution, adding polyvinylpyrrolidone, stirring and dissolving to prepare solution C;

[0032] (4) Dissolve 2-methylimidazole in deionized water, stir to dissolve, and prepare solution D;

[0033] (5) At room temperature, mix solution A and solution C uniformly, slowly add to solution B, and stir well;

[0034] (6) At room temperature, add solution D dropwise to the solution obtained in step (5) with a syringe, adjust the pH value to 8.5 with tris buffer, stir and react for 24 hours, and then centrifuge to obtain Precipitation is the crude product;

[0035] (7) Utilize the ethanol aqueous sol...

Embodiment 2

[0038] A preparation method of a hybrid metal organic framework compound for drug release, the steps are as follows:

[0039] (1) Dissolve doxorubicin in deionized water, stir to dissolve, and prepare solution A;

[0040] (2) Dissolve zinc nitrate in deionized water, stir to dissolve, and prepare solution B;

[0041] (3) Dissolving dopamine hydrochloride in a 45 mass % ethanol aqueous solution, adding polyvinylpyrrolidone, stirring and dissolving to prepare solution C;

[0042] (4) Dissolve 2-methylimidazole in deionized water, stir to dissolve, and prepare solution D;

[0043] (5) At room temperature, mix solution A and solution C uniformly, slowly add to solution B, and stir well;

[0044] (6) At room temperature, add solution D dropwise to the solution obtained in step (5) with a syringe, adjust the pH value to 8.5 with tris buffer, stir and react for 28 hours, and then centrifuge to obtain Precipitation is the crude product;

[0045] (7) Utilize 45 mass % ethanol aqueo...

Embodiment 3

[0048] A preparation method of a hybrid metal organic framework compound for drug release, the steps are as follows:

[0049] (1) Dissolve doxorubicin in deionized water, stir to dissolve, and prepare solution A;

[0050] (2) Dissolve zinc nitrate in deionized water, stir to dissolve, and prepare solution B;

[0051] (3) Dissolving dopamine hydrochloride in a 50 mass % ethanol aqueous solution, adding polyvinylpyrrolidone, stirring and dissolving to prepare solution C;

[0052] (4) Dissolve 2-methylimidazole in deionized water, stir to dissolve, and make solution D;

[0053] (5) At room temperature, mix solution A and solution C evenly, slowly add to solution B, and stir evenly;

[0054] (6) At room temperature, use a syringe to add solution D dropwise to the solution obtained in step (5), adjust the pH value to 8.5 with tris buffer solution, stir and react for 32 hours, and centrifuge to obtain Precipitation is the crude product;

[0055] (7) The crude product was washed th...

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Abstract

The invention provides a preparing method of a hybridization metal organic framework compound for drug release. According to the preparing method, synthesis of a zeolite imidazole framework-8 (ZIF-8)and loading of polydopamine (PDA) and doxorubicin (DOX) are achieved through one-step-method in-situ polymerization, and the metal organic framework-polydopamine-doxorubicin hybridization metal organic framework compound is prepared. The PDA and the DOX are encapsulated in a ZIF-8 crystal, pH and near-infrared double-response drug release and photo-thermal therapy and chemotherapy combination areachieved, the preparing method has excellent pH control drug release performance, and the disease treatment efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of porous material preparation and drug controllable release, and in particular relates to a preparation method of a hybrid metal-organic framework compound for drug release. Background technique [0002] Metal-Organic Frameworks (MOFs), also known as coordination polymers, are a class of periodic polymers formed by the self-assembly of organic ligands and central metal ions or central metal clusters through coordination bonds. Structure of porous materials. When the size of metal-organic framework compounds is reduced to nano-scale, compared with existing drug carriers, nano-scale metal-organic framework compounds have many advantages, such as tunable composition and structure, higher specific surface and specific volume, drug It has strong loading capacity, good biodegradability and excellent biocompatibility. [0003] Photothermal therapy uses the unique photothermal conversion ability of photothermal m...

Claims

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Application Information

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IPC IPC(8): A61K47/54A61K31/704A61K41/00A61P35/00
CPCA61K47/545A61K31/704A61K41/0052A61P35/00A61K2300/00
Inventor 韩会娟曲黎侯玉霞刘萍俞宁
Owner HENAN INST OF SCI & TECH
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