Guided bone tissue regeneration film, preparation method and application

Abstract

The invention provides a membrane for guiding bone tissue regeneration, a preparation method and application. The preparation method of the guided bone tissue regeneration membrane comprises the following steps: a. mixing the medical degradable material with an organic solvent to prepare a polymer solution; b. mixing the polymer solution prepared in step a with pre-prepared dexamethasone The solution is mixed evenly to obtain an electrospinning solution; c. the electrospinning solution prepared in step b is used for electrospinning to obtain an electrospinning film; d. the electrospinning film prepared in step c is sequentially dried to obtain Remove the solvent and dopamine surface functionalization treatment to obtain a functionalized membrane; e. soak the functionalized membrane prepared in step d in the pre-prepared antibacterial polypeptide solution and take it out; f. rinse the membrane prepared in step e with distilled water in sequence ,drying. The guiding bone tissue regeneration membrane provided by the invention has beneficial effects such as degradability, strong biocompatibility, promotion of osteogenic differentiation and growth, antibacterial and the like.

Description

technical field [0001] The application relates to the technical field of medical materials, in particular to a degradable and antibacterial polypeptide-modified guided bone tissue regeneration film, a preparation method and application. Background technique [0002] Guided Bone Regeneration (English full name: Guided Bone Regeneration, referred to as GBR) technology is one of the most commonly used and most effective clinical bone augmentation techniques. Guided bone tissue regeneration membrane has good bone tissue regeneration ability, and is widely used in the treatment of bone defects, Oral craniomaxillofacial defect repair and implantation and other fields. [0003] The emergence of electrospun membranes has effectively improved some of the defects of traditional GBR membranes. These defects include: lack of three-dimensional space structure, flat film formation cannot provide enough space for growth, extension, and proliferation of bone cells; the multifunctionality of...

AI Technical Summary

Problems solved by technology

[0003] The emergence of electrospun membranes has effectively improved some of the defects of traditional GBR membranes. These defects include: lack of three-dimensional space structure, flat film formation cannot provide enough space for growth, extension, and proliferation of bone cells; the multifunctionality of the material cannot be realized. sex

[0004] Moreover, medical degradable materials have good biocompatibility and plasticity, which provides a basis for the further clinical application of bone implant materials and the realization of multi-functionalization of guided bone tissue regeneration membranes, but the simple biodegradable medical implants Material composite electrospun membranes have defects such as weak bone conduction performance and low cell response in tissue repair applications, which largely limit the clinical application of electrospun membranes; and, in clinical studies, it was found that , large areas of bone tissue damage are generally accompanied by the threat of inflammation, which hinders further bone tissue repair