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Antibacterial and anti-inflammatory dendrobium toothpaste

An antibacterial, anti-inflammatory, and dendrobium technology, applied in the field of daily necessities, can solve the problems of reagent consumption, long extraction time, ultrasonic attenuation, etc., and achieve the effects of avoiding gum bleeding, simple and scientific formula, and avoiding tooth damage.

Active Publication Date: 2019-07-26
WUHAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the existing preparation methods of Dendrobium extract are water extraction or alcohol extraction, organic solvent extraction, ultrasonic extraction and supercritical extraction; the method of simply using water extraction or alcohol extraction has a long extraction time, consumes reagents, and cannot Completely extracting the biologically active components in the dendrobium can not fully reflect the efficacy of the dendrobium; the extraction by ultrasonic method has the disadvantages of ultrasonic attenuation, high noise, strong radiation, etc., which is not suitable for industrial production; the method of supercritical extraction is used to produce The obtained dendrobium extract makes the chemical components with large molecular weight and high polarity not extracted, the extraction rate is low, and the production cost is too high
[0006] The dissolution of active ingredients of Chinese medicinal materials is also closely related to the degree of crushing. With the increase of wall breaking rate, the dissolution of active ingredients can be improved, the utilization value of Chinese medicinal materials can be improved, and the quality of products can be improved; adding Dendrobium to toothpaste is expected to improve disease Prevention and nursing care; however, how to maximize the efficacy and deep processing of Dendrobium has become a difficult problem that people have devoted to research in recent years; at present, the more common way to add Dendrobium is to make it into Dendrobium powder and add it to the medicine, but , the common method of making dendrobium powder has a low cell wall breaking rate, resulting in a low overall utilization rate of the medicinal material, and a low release rate in the human body and traditional Chinese medicine preparations, which further affects the efficacy of the medicine

Method used

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Examples

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Embodiment 1

[0042] An antibacterial and anti-inflammatory dendrobium toothpaste, comprising the following components in parts by weight: 12 parts of dendrobium extract, 10 parts of wetting agent, 8 parts of friction agent, 0.6 part of potassium sorbate, 0.8 part of thickener, lauryl 4 parts of sodium sulfate, 0.3 parts of sweetener, 10 parts of nano-hydroxyapatite, and 20 parts of deionized water.

[0043] The extracting method of described dendrobium extract, comprises the steps:

[0044] S1. Fresh dendrobium was washed and put into a low-temperature drying box, and freeze-dried at -40°C;

[0045] S2, the dendrobium of freezing is poured into crusher and broken;

[0046]S3. Take the crushed dendrobium powder, add disodium hydrogen phosphate-citric acid buffer solution as the simulated gastric juice extractant according to the ratio of solid to liquid 1g:30mL, adjust the pH value of the system to 2.5, fully oscillate and extract in a water bath at 50°C Filter after 1.5h;

[0047] S4. A...

Embodiment 2

[0054] This embodiment provides an antibacterial and anti-inflammatory Dendrobium toothpaste. Compared with Example 1, the difference is that it includes the following components in parts by weight: 2 parts of Dendrobium extract, 15 parts of wetting agent, 5 parts of friction agent, 0.8 parts of potassium sorbate, 1 part of thickener, 5 parts of sodium lauryl sulfate, 0.2 parts of sweetener, 5 parts of nano-hydroxyapatite, and 25 parts of deionized water.

Embodiment 3

[0056] This embodiment provides an antibacterial and anti-inflammatory Dendrobium toothpaste. Compared with Example 1, the difference is that it includes the following components in parts by weight: 20 parts of Dendrobium extract, 5 parts of wetting agent, 10 parts of friction agent, 0.5 parts of potassium sorbate, 0.5 parts of thickener, 2 parts of sodium lauryl sulfate, 0.5 parts of sweetener, 15 parts of nano-hydroxyapatite, and 15 parts of deionized water.

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Abstract

The invention discloses antibacterial and anti-inflammatory dendrobium toothpaste comprising, by weight parts, 2-20 parts of dendrobium extract, 5-15 parts of wetting agent, 5-10 parts of friction agent, 0.5-0.8 part of potassium sorbate, 0.5-1.0 part of thickener, 2-5 parts of sodium lauryl sulfate, 0.2-0.5 part of sweetener, 5-15 parts of nano-hydroxyapatite and 15-25 parts of deionized water. The antibacterial and anti-inflammatory dendrobium toothpaste is low in raw material cost, the formula is simple and scientific, active ingredients in dendrobium are extracted by combining a semi-bionic method and a biological enzyme, and the process of adsorption and transport of the dendrobium in the gastrointestinal tract in vivo after oral administration is simulated. Compared with the semi-bionic method or the enzymic method which is used independently, the method has high extraction efficiency, is favorable for fully exerting the effect of the active components of the dendrobium, is simple to operate and environmentally friendly, is suitable for industrial large-scale production, and has good application value.

Description

technical field [0001] The invention relates to the field of daily necessities, in particular to an antibacterial and anti-inflammatory dendrobium toothpaste. Background technique [0002] The main pathological changes of chronic atrophic gastritis are mucosal gland atrophy, thinning, and inflammation, which may be accompanied by metaplasia and dysplasia of intestinal gland epithelium. The incidence rate accounts for 10-20% of all chronic gastritis. Listed as a precancerous state of the stomach. [0003] Toothpaste is an indispensable oral hygiene product in people's daily life. With the enhancement of people's awareness of health care, consumers have higher and higher requirements for toothpaste. Functional toothpaste with active ingredients of traditional Chinese medicine has become a mainstream development direction of the market. But the effect of some existing toothpaste with Chinese medicine as active ingredient is not obvious. [0004] Dendrobium is a famous and pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/46A61K8/36A61K8/24A61P1/02A61P7/04A61P1/04A61Q11/00
CPCA61K8/9794A61K8/463A61K8/24A61K8/9789A61K8/36A61Q11/00A61P1/02A61P7/04A61P1/04A61K2800/28
Inventor 周劭周建安钟捷
Owner WUHAN UNIV OF SCI & TECH